Aliases for TSPAN15 Gene
External Ids for TSPAN15 Gene
Previous HGNC Symbols for TSPAN15 Gene
Previous GeneCards Identifiers for TSPAN15 Gene
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TSPAN15 Gene
TSPAN15 (Tetraspanin 15) is a Protein Coding gene. Diseases associated with TSPAN15 include Femoral Vein Thrombophlebitis and Corneal Dystrophy, Subepithelial Mucinous. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN17.
UniProtKB/Swiss-Prot Summary for TSPAN15 Gene
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).