The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use ... See more...

Aliases for TSPAN15 Gene

Aliases for TSPAN15 Gene

  • Tetraspanin 15 2 3 5
  • Transmembrane 4 Superfamily Member 15 2 3 4
  • Tetraspan NET-7 3 4
  • Tetraspanin-15 3 4
  • Tspan-15 3 4
  • TM4SF15 3 4
  • NET7 3 4
  • Transmembrane 4 Superfamily Member Tetraspan NET-7 3
  • 2700063A19Rik 3
  • NET-7 3

External Ids for TSPAN15 Gene

Previous HGNC Symbols for TSPAN15 Gene

  • TM4SF15

Previous GeneCards Identifiers for TSPAN15 Gene

  • GC10P070882
  • GC10P071211
  • GC10P065211

Summaries for TSPAN15 Gene

Entrez Gene Summary for TSPAN15 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN15 Gene

TSPAN15 (Tetraspanin 15) is a Protein Coding gene. Diseases associated with TSPAN15 include Femoral Vein Thrombophlebitis and Corneal Dystrophy, Subepithelial Mucinous. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN17.

UniProtKB/Swiss-Prot Summary for TSPAN15 Gene

  • Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).

Additional gene information for TSPAN15 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSPAN15 Gene

Genomics for TSPAN15 Gene

GeneHancer (GH) Regulatory Elements for TSPAN15 Gene

Promoters and enhancers for TSPAN15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSPAN15

Top Transcription factor binding sites by QIAGEN in the TSPAN15 gene promoter:
  • c-Myb
  • CUTL1
  • E47
  • GATA-1
  • Hand1
  • HNF-4alpha1
  • SRF
  • SRF (504 AA)

Genomic Locations for TSPAN15 Gene

Genomic Locations for TSPAN15 Gene
chr10:69,425,218-69,507,669
(GRCh38/hg38)
Size:
82,452 bases
Orientation:
Plus strand
chr10:71,211,226-71,267,425
(GRCh37/hg19)
Size:
56,200 bases
Orientation:
Plus strand

Genomic View for TSPAN15 Gene

Genes around TSPAN15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN15 Gene

Proteins for TSPAN15 Gene

  • Protein details for TSPAN15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95858-TSN15_HUMAN
    Recommended name:
    Tetraspanin-15
    Protein Accession:
    O95858
    Secondary Accessions:
    • Q6UW79

    Protein attributes for TSPAN15 Gene

    Size:
    294 amino acids
    Molecular mass:
    33165 Da
    Quaternary structure:
    • Interacts with ADAM10; the interaction influences ADAM10 substrate specificity.

neXtProt entry for TSPAN15 Gene

Post-translational modifications for TSPAN15 Gene

  • Glycosylation at Asn118, Asn189, and Asn230
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN15 Gene

No data available for DME Specific Peptides for TSPAN15 Gene

Domains & Families for TSPAN15 Gene

Gene Families for TSPAN15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for TSPAN15 Gene

Blocks:
  • Transmembrane four family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSPAN15 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane 4 superfamily member 15 (TSN15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95858

UniProtKB/Swiss-Prot:

TSN15_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN15: view

Function for TSPAN15 Gene

Molecular function for TSPAN15 Gene

UniProtKB/Swiss-Prot Function:
Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862).

Phenotypes From GWAS Catalog for TSPAN15 Gene

Gene Ontology (GO) - Molecular Function for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23091066
GO:0019899 enzyme binding IEA,IPI 23091066
genes like me logo Genes that share ontologies with TSPAN15: view
genes like me logo Genes that share phenotypes with TSPAN15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN15

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN15 Gene

Localization for TSPAN15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN15 Gene

Cell membrane; Multi-pass membrane protein. Late endosome membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN15 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
endosome 3
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with TSPAN15: view

Pathways & Interactions for TSPAN15 Gene

PathCards logo

SuperPathways for TSPAN15 Gene

No Data Available

SIGNOR curated interactions for TSPAN15 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TSPAN15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008593 NOT regulation of Notch signaling pathway IMP 23091066
GO:0044267 cellular protein metabolic process TAS --
GO:0045746 negative regulation of Notch signaling pathway IDA 30463011
GO:0051604 protein maturation IBA,IMP 23091066
GO:0072659 protein localization to plasma membrane IMP 23091066
genes like me logo Genes that share ontologies with TSPAN15: view

No data available for Pathways by source for TSPAN15 Gene

Drugs & Compounds for TSPAN15 Gene

No Compound Related Data Available

Transcripts for TSPAN15 Gene

mRNA/cDNA for TSPAN15 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN15

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN15 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for TSPAN15 Gene

GeneLoc Exon Structure for
TSPAN15

Expression for TSPAN15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN15 Gene

Protein differential expression in normal tissues from HIPED for TSPAN15 Gene

This gene is overexpressed in Frontal cortex (12.6), Pancreas (8.2), and Spinal cord (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN15 Gene



Protein tissue co-expression partners for TSPAN15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSPAN15

SOURCE GeneReport for Unigene cluster for TSPAN15 Gene:

Hs.499941

Evidence on tissue expression from TISSUES for TSPAN15 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with TSPAN15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN15 Gene

Orthologs for TSPAN15 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN15 31 30
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN15 31 30
  • 91.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN15 31 30
  • 91.24 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tspan15 17 31 30
  • 88.1 (n)
rat
(Rattus norvegicus)
Mammalia Tspan15 30
  • 86.28 (n)
oppossum
(Monodelphis domestica)
Mammalia TSPAN15 31
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSPAN15 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN15 31 30
  • 75.77 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN15 31
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan15 30
  • 68.05 (n)
Str.1562 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6438 30
zebrafish
(Danio rerio)
Actinopterygii tspan15 31 30
  • 66.55 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tsp3A 31
  • 30 (a)
ManyToMany
Tsp86D 31
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToOne
Species where no ortholog for TSPAN15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN15 Gene

ENSEMBL:
Gene Tree for TSPAN15 (if available)
TreeFam:
Gene Tree for TSPAN15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSPAN15: view image

Paralogs for TSPAN15 Gene

(6) SIMAP similar genes for TSPAN15 Gene using alignment to 2 proteins:

  • TSN15_HUMAN
  • H7C285_HUMAN
genes like me logo Genes that share paralogs with TSPAN15: view

Variants for TSPAN15 Gene

Additional dbSNP identifiers (rs#s) for TSPAN15 Gene

Structural Variations from Database of Genomic Variants (DGV) for TSPAN15 Gene

Variant ID Type Subtype PubMed ID
esv2678828 CNV deletion 23128226
esv32737 CNV gain+loss 17666407
esv3623745 CNV gain 21293372
esv3623746 CNV loss 21293372
nsv467356 CNV loss 19166990
nsv508590 CNV deletion 20534489
nsv523004 CNV loss 19592680
nsv524063 CNV loss 19592680
nsv524514 CNV loss 19592680
nsv551454 CNV loss 21841781
nsv7021 CNV deletion 18451855

Variation tolerance for TSPAN15 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSPAN15 Gene

Disorders for TSPAN15 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TSPAN15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
femoral vein thrombophlebitis
  • phlebitis and thrombophlebitis of femoral vein
corneal dystrophy, subepithelial mucinous
  • smcd
epithelial and subepithelial dystrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TSPAN15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TSPAN15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN15 Gene

Publications for TSPAN15 Gene

  1. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. (PMID: 30463011) Shah J … Citi S (Cell reports 2018) 3 4 54
  2. TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization. (PMID: 26686862) Jouannet S … Rubinstein E (Cellular and molecular life sciences : CMLS 2016) 3 4 54
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54

Products for TSPAN15 Gene

Sources for TSPAN15 Gene