Aliases for TSPAN11 Gene

Aliases for TSPAN11 Gene

  • Tetraspanin 11 2 3 5
  • Tetraspanin-11 3 4
  • Tspan-11 3 4
  • VSSW1971 3
  • TSPAN11 5

External Ids for TSPAN11 Gene

Previous GeneCards Identifiers for TSPAN11 Gene

  • GC12P030985
  • GC12P030844
  • GC12P031079

Summaries for TSPAN11 Gene

GeneCards Summary for TSPAN11 Gene

TSPAN11 (Tetraspanin 11) is a Protein Coding gene. An important paralog of this gene is CD151.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSPAN11 Gene

Genomics for TSPAN11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TSPAN11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J030926 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 253 +1.0 1005 2.9 SIN3A KLF9 ZBTB48 TAF1 EZH2 BHLHE40 NFIB PRDM4 ZNF18 EGR2 TSPAN11 piR-57551 lnc-CAPRIN2-2 DDX11
GH12J030930 Promoter 0.4 EPDnew 250.7 +4.0 3981 0.1 NR2F2 TSPAN11 piR-57551 lnc-CAPRIN2-2 DDX11
GH12J030925 Enhancer 0.2 CraniofacialAtlas 250.7 -0.7 -661 0.2 TSPAN11 RF00017-1122 lnc-CAPRIN2-2 CAPRIN2
GH12J030908 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 20.1 -17.3 -17295 2.9 FOXA2 SMAD4 MAFF BCL6 SOX5 JUND ELF3 GLIS1 MAFK NFIA TSPAN11 LINC00941 RF00017-1122 CAPRIN2
GH12J030874 Enhancer 0.7 Ensembl 12.5 -51.4 -51427 0.4 FEZF1 ZIC2 ZNF843 PRDM6 ZNF2 INSM2 ZBTB48 GLIS1 SP7 ZFP69B TSPAN11 LOC107984476 HSALNG0090155 PPIAP44 ENSG00000285517 CAPRIN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSPAN11

Top Transcription factor binding sites by QIAGEN in the TSPAN11 gene promoter:
  • c-Ets-1
  • C/EBPalpha
  • Cart-1
  • Evi-1
  • HOXA3
  • RSRFC4
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • TBP

Genomic Locations for TSPAN11 Gene

Latest Assembly
90,075 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
69,853 bases
Plus strand

(GRCh37/hg19 by Ensembl)
70,173 bases
Plus strand

Genomic View for TSPAN11 Gene

Genes around TSPAN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN11 Gene

Proteins for TSPAN11 Gene

  • Protein details for TSPAN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A1L158
    • B2RUX6

    Protein attributes for TSPAN11 Gene

    253 amino acids
    Molecular mass:
    28245 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN11 Gene

Post-translational modifications for TSPAN11 Gene

  • Glycosylation at Asn127
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN11 Gene

No data available for DME Specific Peptides for TSPAN11 Gene

Domains & Families for TSPAN11 Gene

Gene Families for TSPAN11 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TSPAN11 Gene

Suggested Antigen Peptide Sequences for TSPAN11 Gene

GenScript: Design optimal peptide antigens:
  • Tetraspanin-11 (TSN11_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN11: view

Function for TSPAN11 Gene

Phenotypes From GWAS Catalog for TSPAN11 Gene

genes like me logo Genes that share phenotypes with TSPAN11: view

Animal Models for TSPAN11 Gene

MGI Knock Outs for TSPAN11:
  • Tspan11 Tspan11<tm2b(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN11

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSPAN11 Gene

Localization for TSPAN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN11 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN11 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TSPAN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN11: view

Pathways & Interactions for TSPAN11 Gene

PathCards logo

SuperPathways for TSPAN11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration IBA 21873635
genes like me logo Genes that share ontologies with TSPAN11: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN11 Gene

Drugs & Compounds for TSPAN11 Gene

No Compound Related Data Available

Transcripts for TSPAN11 Gene

mRNA/cDNA for TSPAN11 Gene

9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSPAN11

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -

Relevant External Links for TSPAN11 Gene

GeneLoc Exon Structure for

Expression for TSPAN11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSPAN11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSPAN11 Gene

This gene is overexpressed in Colon - Sigmoid (x4.7).

Protein differential expression in normal tissues from HIPED for TSPAN11 Gene

This gene is overexpressed in Colon (42.0), Rectum (13.8), and Prostate (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSPAN11 Gene

Protein tissue co-expression partners for TSPAN11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSPAN11

SOURCE GeneReport for Unigene cluster for TSPAN11 Gene:


Evidence on tissue expression from TISSUES for TSPAN11 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TSPAN11: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN11 Gene

Orthologs for TSPAN11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN11 30 31
  • 99.12 (n)
(Canis familiaris)
Mammalia TSPAN11 30 31
  • 88.67 (n)
(Bos Taurus)
Mammalia TSPAN11 30 31
  • 86.43 (n)
(Rattus norvegicus)
Mammalia Tspan11 30
  • 84.85 (n)
(Mus musculus)
Mammalia Tspan11 30 17 31
  • 84.19 (n)
(Monodelphis domestica)
Mammalia TSPAN11 31
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia TSPAN11 31
  • 65 (a)
(Gallus gallus)
Aves -- 31
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 27 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101732684 30
  • 62.95 (n)
(Danio rerio)
Actinopterygii tspan11 30 31
  • 70.63 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta Tsp74F 31
  • 31 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8828 31
  • 42 (a)
Species where no ortholog for TSPAN11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TSPAN11 Gene

Gene Tree for TSPAN11 (if available)
Gene Tree for TSPAN11 (if available)
Evolutionary constrained regions (ECRs) for TSPAN11: view image

Paralogs for TSPAN11 Gene

(15) SIMAP similar genes for TSPAN11 Gene using alignment to 4 proteins:

  • F5H0F0_HUMAN
  • F5H195_HUMAN
  • F5H2P0_HUMAN Pseudogenes for TSPAN11 Gene

genes like me logo Genes that share paralogs with TSPAN11: view

Variants for TSPAN11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSPAN11 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs2075333 - p.Val190Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TSPAN11 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TSPAN11 Gene

Variant ID Type Subtype PubMed ID
dgv1413n100 CNV gain 25217958
dgv1414n100 CNV gain 25217958
dgv1415n100 CNV gain 25217958
dgv1416n100 CNV gain 25217958
dgv7e196 CNV duplication 17116639
esv2422447 CNV duplication 17116639
esv25193 CNV loss 19812545
esv2676723 CNV deletion 23128226
esv2745711 CNV deletion 23290073
esv2751043 CNV gain 17911159
esv2759890 CNV gain+loss 17122850
esv3303087 CNV tandem duplication 20981092
esv3306795 CNV mobile element insertion 20981092
esv3309360 CNV mobile element insertion 20981092
esv3342394 CNV insertion 20981092
esv3360756 CNV insertion 20981092
esv3581161 CNV gain 25503493
esv3629028 CNV gain 21293372
esv3629029 CNV loss 21293372
nsv1035182 CNV gain 25217958
nsv1038745 CNV gain 25217958
nsv1043720 CNV gain 25217958
nsv1118231 CNV deletion 24896259
nsv1147184 CNV insertion 26484159
nsv428276 CNV gain 18775914
nsv469193 CNV loss 19166990
nsv520694 CNV loss 19592680
nsv522849 CNV gain 19592680
nsv524047 CNV loss 19592680
nsv525788 CNV loss 19592680
nsv558030 CNV gain 21841781
nsv558031 CNV loss 21841781
nsv658 CNV deletion 18451855
nsv832362 CNV loss 17160897

Variation tolerance for TSPAN11 Gene

Residual Variation Intolerance Score: 71.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN11 Gene

Disorders for TSPAN11 Gene

Additional Disease Information for TSPAN11

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TSPAN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN11 Gene

Publications for TSPAN11 Gene

  1. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for TSPAN11 Gene

Sources for TSPAN11 Gene