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Aliases for TSPAN10 Gene

Aliases for TSPAN10 Gene

  • Tetraspanin 10 2 3 5
  • Oculospanin 2 3 4
  • Tspan-10 3 4
  • OCSP 3 4
  • Tetraspanin-10 3

External Ids for TSPAN10 Gene

Previous GeneCards Identifiers for TSPAN10 Gene

  • GC17P077220
  • GC17P079609
  • GC17P075055

Summaries for TSPAN10 Gene

GeneCards Summary for TSPAN10 Gene

TSPAN10 (Tetraspanin 10) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN17.

UniProtKB/Swiss-Prot for TSPAN10 Gene

  • Regulates maturation of the transmembrane metalloprotease ADAM10.

Additional gene information for TSPAN10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN10 Gene

Genomics for TSPAN10 Gene

GeneHancer (GH) Regulatory Elements for TSPAN10 Gene

Promoters and enhancers for TSPAN10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I081635 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 575.8 -0.7 -720 2.6 HDGF SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 TSPAN10 NPLOC4 ARL16 CHMP6 HEXDC ENSG00000260563 TEPSIN FAAP100 NARF-IT1 OGFOD3
GH17I081641 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 575.4 +5.1 5075 1.1 ZNF121 FOSL2 FOS TSPAN10 ARL16 CCDC137 NPLOC4
GH17I081596 Enhancer 1.2 Ensembl ENCODE dbSUPER 34 -37.7 -37711 5.4 HDGF CTCF BACH1 IRF4 RAD21 ZNF316 POLR2A SMC3 ZNF143 ZNF391 TSPAN10 NPLOC4 ARL16 FAAP100 PDE6G OXLD1 CCDC137 TMEM105 GC17M081598 GC17M081601
GH17I081558 Enhancer 1.2 Ensembl ENCODE dbSUPER 33.4 -72.8 -72809 11.1 PKNOX1 FOXA2 NFIB ZSCAN4 SIN3A FEZF1 BATF RAD21 ZNF366 ATF7 NPLOC4 TSPAN10 ARL16 OXLD1 ENSG00000229848 FSCN2 ENSG00000262877 PDE6G CCDC137 GCGR
GH17I081384 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.3 -241.1 -241067 22.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF263 BAHCC1 ENSG00000279692 ENSG00000262877 CEP131 GPS1 HGS ENSG00000260011 FAAP100 ENSG00000260369 ENSG00000265678
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSPAN10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN10 gene promoter:

Genomic Locations for TSPAN10 Gene

Genomic Locations for TSPAN10 Gene
11,585 bases
Plus strand

Genomic View for TSPAN10 Gene

Genes around TSPAN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN10 Gene

Proteins for TSPAN10 Gene

  • Protein details for TSPAN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8N548

    Protein attributes for TSPAN10 Gene

    355 amino acids
    Molecular mass:
    36498 Da
    Quaternary structure:
    • Interacts with ADAM10.

neXtProt entry for TSPAN10 Gene

Post-translational modifications for TSPAN10 Gene

  • Glycosylation at isoforms=228
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN10 Gene

No data available for DME Specific Peptides for TSPAN10 Gene

Domains & Families for TSPAN10 Gene

Gene Families for TSPAN10 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TSPAN10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN10: view

Function for TSPAN10 Gene

Molecular function for TSPAN10 Gene

UniProtKB/Swiss-Prot Function:
Regulates maturation of the transmembrane metalloprotease ADAM10.

Phenotypes From GWAS Catalog for TSPAN10 Gene

Gene Ontology (GO) - Molecular Function for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN10: view

Phenotypes for TSPAN10 Gene

genes like me logo Genes that share phenotypes with TSPAN10: view

miRNA for TSPAN10 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN10 Gene

Localization for TSPAN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN10 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN10: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TSPAN10 Gene

Pathways & Interactions for TSPAN10 Gene

SuperPathways for TSPAN10 Gene

No Data Available

Interacting Proteins for TSPAN10 Gene

Gene Ontology (GO) - Biological Process for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0072594 establishment of protein localization to organelle IDA 23091066
genes like me logo Genes that share ontologies with TSPAN10: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN10 Gene

Drugs & Compounds for TSPAN10 Gene

No Compound Related Data Available

Transcripts for TSPAN10 Gene

Unigene Clusters for TSPAN10 Gene

Tetraspanin 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN10 Gene

No ASD Table

Relevant External Links for TSPAN10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN10 Gene

Protein differential expression in normal tissues from HIPED for TSPAN10 Gene

This gene is overexpressed in Breast (16.2), Spleen (9.5), Retina (9.1), Stomach (9.1), Uterus (6.8), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN10 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN10 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN10 Gene:


mRNA Expression by UniProt/SwissProt for TSPAN10 Gene:

Tissue specificity: Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).
genes like me logo Genes that share expression patterns with TSPAN10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN10 Gene

Orthologs for TSPAN10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN10 33 34
  • 99.15 (n)
(Bos Taurus)
Mammalia TSPAN10 33 34
  • 81.28 (n)
(Canis familiaris)
Mammalia TSPAN10 33 34
  • 77.44 (n)
(Rattus norvegicus)
Mammalia Tspan10 33
  • 73.18 (n)
(Mus musculus)
Mammalia Tspan10 33 16 34
  • 71.52 (n)
(Monodelphis domestica)
Mammalia TSPAN10 34
  • 52 (a)
(Gallus gallus)
Aves TSPAN10 33 34
  • 64.41 (n)
(Anolis carolinensis)
Reptilia TSPAN10 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731851 33
  • 53.62 (n)
(Danio rerio)
Actinopterygii LOC799194 33
  • 51.42 (n)
CR855387.1 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea tsp-14 34
  • 18 (a)
Species where no ortholog for TSPAN10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN10 Gene

Gene Tree for TSPAN10 (if available)
Gene Tree for TSPAN10 (if available)

Paralogs for TSPAN10 Gene

(7) SIMAP similar genes for TSPAN10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSPAN10: view

Variants for TSPAN10 Gene

Sequence variations from dbSNP and Humsavar for TSPAN10 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000126252 -- 81,645,382(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000202766 -- 81,637,097(+) G/A upstream_transcript_variant
rs1000327775 -- 81,645,694(+) C/T intron_variant
rs1000803042 -- 81,637,984(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000867415 -- 81,639,185(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN10 Gene

Variant ID Type Subtype PubMed ID
dgv1523n106 CNV deletion 24896259
esv1711846 CNV deletion 17803354
esv1981187 CNV deletion 18987734
esv26223 CNV gain+loss 19812545
esv2674289 CNV deletion 23128226
esv2716455 CNV deletion 23290073
esv2716456 CNV deletion 23290073
esv3554887 CNV deletion 23714750
nsv1071813 CNV deletion 25765185
nsv1148351 CNV deletion 26484159
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828128 CNV loss 20364138
nsv952390 CNV deletion 24416366

Additional Variant Information for TSPAN10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TSPAN10 Gene

Disorders for TSPAN10 Gene

Additional Disease Information for TSPAN10

No disorders were found for TSPAN10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN10 Gene

Publications for TSPAN10 Gene

  1. Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G … Peterson K (Molecular vision 2002) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals. (PMID: 23091066) Dornier E … Rubinstein E (The Journal of cell biology 2012) 3 58
  5. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3 58

Products for TSPAN10 Gene

Sources for TSPAN10 Gene

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