Aliases for TSPAN10 Gene

Aliases for TSPAN10 Gene

  • Tetraspanin 10 2 3 5
  • Oculospanin 2 3 4
  • Tetraspanin-10 3 4
  • Tspan-10 3 4
  • OCSP 3 4

External Ids for TSPAN10 Gene

Previous GeneCards Identifiers for TSPAN10 Gene

  • GC17P077220
  • GC17P079609
  • GC17P075055

Summaries for TSPAN10 Gene

GeneCards Summary for TSPAN10 Gene

TSPAN10 (Tetraspanin 10) is a Protein Coding gene. Diseases associated with TSPAN10 include Strabismus. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is TSPAN5.

UniProtKB/Swiss-Prot Summary for TSPAN10 Gene

Additional gene information for TSPAN10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSPAN10 Gene

Genomics for TSPAN10 Gene

GeneHancer (GH) Regulatory Elements for TSPAN10 Gene

Promoters and enhancers for TSPAN10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSPAN10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN10 gene promoter:
  • STAT5A

Genomic Locations for TSPAN10 Gene

Genomic Locations for TSPAN10 Gene
chr17:81,637,171-81,648,755
(GRCh38/hg38)
Size:
11,585 bases
Orientation:
Plus strand
chr17:79,604,197-79,615,779
(GRCh37/hg19)
Size:
11,583 bases
Orientation:
Plus strand

Genomic View for TSPAN10 Gene

Genes around TSPAN10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN10 Gene

Proteins for TSPAN10 Gene

  • Protein details for TSPAN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1Z9-TSN10_HUMAN
    Recommended name:
    Tetraspanin-10
    Protein Accession:
    Q9H1Z9
    Secondary Accessions:
    • Q8N548

    Protein attributes for TSPAN10 Gene

    Size:
    355 amino acids
    Molecular mass:
    36498 Da
    Quaternary structure:
    • Interacts with ADAM10.

neXtProt entry for TSPAN10 Gene

Post-translational modifications for TSPAN10 Gene

  • Glycosylation at Asn228
  • Modification sites at PhosphoSitePlus

Other Protein References for TSPAN10 Gene

No data available for DME Specific Peptides for TSPAN10 Gene

Domains & Families for TSPAN10 Gene

Gene Families for TSPAN10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TSPAN10 Gene

GenScript: Design optimal peptide antigens:
  • Tetraspanin-10 (F1T0E7_HUMAN)
  • Tetraspanin-10 (F1T0E8_HUMAN)
  • Oculospanin (TSN10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H1Z9

UniProtKB/Swiss-Prot:

TSN10_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN10: view

Function for TSPAN10 Gene

Molecular function for TSPAN10 Gene

UniProtKB/Swiss-Prot Function:
Regulates maturation of the transmembrane metalloprotease ADAM10.

Phenotypes From GWAS Catalog for TSPAN10 Gene

Gene Ontology (GO) - Molecular Function for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN10: view
genes like me logo Genes that share phenotypes with TSPAN10: view

Animal Model Products

CRISPR Products

miRNA for TSPAN10 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN10 Gene

Localization for TSPAN10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN10 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPAN10 Gene

Pathways & Interactions for TSPAN10 Gene

PathCards logo

SuperPathways for TSPAN10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051604 protein maturation IBA 21873635
GO:0072594 establishment of protein localization to organelle IDA 23091066
genes like me logo Genes that share ontologies with TSPAN10: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN10 Gene

Drugs & Compounds for TSPAN10 Gene

No Compound Related Data Available

Transcripts for TSPAN10 Gene

mRNA/cDNA for TSPAN10 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN10 Gene

No ASD Table

Relevant External Links for TSPAN10 Gene

GeneLoc Exon Structure for
TSPAN10
ECgene alternative splicing isoforms for
TSPAN10

Expression for TSPAN10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN10 Gene

Protein differential expression in normal tissues from HIPED for TSPAN10 Gene

This gene is overexpressed in Breast (16.2), Spleen (9.5), Retina (9.1), Stomach (9.1), Uterus (6.8), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSPAN10 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSPAN10 Gene:

TSPAN10

SOURCE GeneReport for Unigene cluster for TSPAN10 Gene:

Hs.740811

mRNA Expression by UniProt/SwissProt for TSPAN10 Gene:

Q9H1Z9-TSN10_HUMAN
Tissue specificity: Expressed in the eye, including iris, ciliary body, retinal pigment epithelium, but not lens (protein level).
genes like me logo Genes that share expression patterns with TSPAN10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN10 Gene

Orthologs for TSPAN10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN10 33 32
  • 99.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN10 33 32
  • 81.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TSPAN10 33 32
  • 77.44 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tspan10 32
  • 73.18 (n)
mouse
(Mus musculus)
Mammalia Tspan10 17 33 32
  • 71.52 (n)
oppossum
(Monodelphis domestica)
Mammalia TSPAN10 33
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSPAN10 33 32
  • 64.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSPAN10 33
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731851 32
  • 53.62 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC799194 32
  • 51.42 (n)
CR855387.1 33
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tsp-14 33
  • 18 (a)
OneToMany
Species where no ortholog for TSPAN10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN10 Gene

ENSEMBL:
Gene Tree for TSPAN10 (if available)
TreeFam:
Gene Tree for TSPAN10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSPAN10: view image

Paralogs for TSPAN10 Gene

(7) SIMAP similar genes for TSPAN10 Gene using alignment to 4 proteins:

  • TSN10_HUMAN
  • F1T0E7_HUMAN
  • F1T0E8_HUMAN
  • Q6PJ65_HUMAN
genes like me logo Genes that share paralogs with TSPAN10: view

Variants for TSPAN10 Gene

Sequence variations from dbSNP and Humsavar for TSPAN10 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000126252 -- 81,645,382(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000202766 -- 81,637,097(+) G/A upstream_transcript_variant
rs1000327775 -- 81,645,694(+) C/T intron_variant
rs1000803042 -- 81,637,984(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000867415 -- 81,639,185(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN10 Gene

Variant ID Type Subtype PubMed ID
dgv1523n106 CNV deletion 24896259
esv1711846 CNV deletion 17803354
esv1981187 CNV deletion 18987734
esv26223 CNV gain+loss 19812545
esv2674289 CNV deletion 23128226
esv2716455 CNV deletion 23290073
esv2716456 CNV deletion 23290073
esv3554887 CNV deletion 23714750
nsv1071813 CNV deletion 25765185
nsv1148351 CNV deletion 26484159
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828128 CNV loss 20364138
nsv952390 CNV deletion 24416366

Additional Variant Information for TSPAN10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TSPAN10 Gene

Disorders for TSPAN10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TSPAN10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
strabismus
  • strabismus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TSPAN10

genes like me logo Genes that share disorders with TSPAN10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN10 Gene

Publications for TSPAN10 Gene

  1. Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G … Peterson K (Molecular vision 2002) 2 3 4 56
  2. A commonly occurring genetic variant within the NPLOC4-TSPAN10-PDE6G gene cluster is associated with the risk of strabismus. (PMID: 31073882) Plotnikov D … UK Biobank Eye and Vision Consortium (Human genetics 2019) 3 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 56
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56

Products for TSPAN10 Gene

  • Biorbyt antibodies for TSPAN10

Sources for TSPAN10 Gene