This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators ... See more...

Aliases for TSN Gene

Aliases for TSN Gene

  • Translin 2 3 4 5
  • Recombination Hotspot Associated Factor 2 3
  • Component 3 Of Promoter Of RISC 3 4
  • C3PO 3 4
  • Recombination Hotspot-Binding Protein 3
  • Testis Brain-RNA Binding Protein 3
  • EC 3.1.-.- 4
  • BCLF-1 3
  • REHF-1 3
  • RCHF1 3
  • TBRBP 3
  • TRSLN 3

External Ids for TSN Gene

Previous GeneCards Identifiers for TSN Gene

  • GC02P119718
  • GC02P120433
  • GC02P122419
  • GC02P122608
  • GC02P122229
  • GC02P114835

Summaries for TSN Gene

Entrez Gene Summary for TSN Gene

  • This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

GeneCards Summary for TSN Gene

TSN (Translin) is a Protein Coding gene. Diseases associated with TSN include Liposarcoma and Dysgerminoma. Among its related pathways are Gene Expression and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is TSNAX.

UniProtKB/Swiss-Prot Summary for TSN Gene

  • DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
  • Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.

Gene Wiki entry for TSN Gene

Additional gene information for TSN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSN Gene

Genomics for TSN Gene

GeneHancer (GH) Regulatory Elements for TSN Gene

Promoters and enhancers for TSN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J121754 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.4 +18.8 18798 3 RXRA FOXK2 ZNF217 EP300 SIN3A NRF1 TCF12 MYC USF1 POLR2G HSALNG0018459 lnc-NIFK-14 TSN lnc-NIFK-8
GH02J121735 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.0 3 3.9 ZBTB40 ZNF217 SIN3A TCF12 NRF1 MYC POLR2G USF1 SP1 PHF8 NIFK TSN LINC01823 FJ601684-251
GH02J121524 Promoter/Enhancer 2.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 -208.0 -207975 9.4 EP300 FOXK2 ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 POLR2G SP1 ENSG00000265451 RNU4ATAC NIFK TSN LINC01823 CLASP1 lnc-TSN-10
GH02J121626 Enhancer 1 Ensembl ENCODE 13.7 -109.6 -109555 2.1 MYC CTBP1 NCOR1 ZNF316 MAFF CEBPG NR3C1 MAFK PBX2 NR2F2 TSN LINC01823 CLASP1 NIFK-AS1 lnc-NIFK-9
GH02J120785 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 10.7 -950.0 -950014 4 ZIC2 GABPA TGIF2 HDAC2 ZBTB17 SAP130 YY1 NANOG ETS1 ZMIZ1 GLI2 TSN lnc-TFCP2L1-5 NONHSAG029119.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSN

Top Transcription factor binding sites by QIAGEN in the TSN gene promoter:
  • AhR
  • Arnt
  • Evi-1
  • FOXC1
  • GATA-1
  • IRF-7A
  • NRF-2
  • Olf-1
  • PPAR-alpha

Genomic Locations for TSN Gene

Genomic Locations for TSN Gene
chr2:121,737,103-121,767,853
(GRCh38/hg38)
Size:
30,751 bases
Orientation:
Plus strand
chr2:122,494,679-122,525,429
(GRCh37/hg19)
Size:
30,751 bases
Orientation:
Plus strand

Genomic View for TSN Gene

Genes around TSN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSN Gene

Proteins for TSN Gene

  • Protein details for TSN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15631-TSN_HUMAN
    Recommended name:
    Translin
    Protein Accession:
    Q15631
    Secondary Accessions:
    • B7Z3X8
    • Q5U0K7

    Protein attributes for TSN Gene

    Size:
    228 amino acids
    Molecular mass:
    26183 Da
    Quaternary structure:
    • Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

    Three dimensional structures from OCA and Proteopedia for TSN Gene

    Alternative splice isoforms for TSN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSN Gene

Post-translational modifications for TSN Gene

  • Ubiquitination at Lys56, Lys187, and Lys219
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSN Gene

Domains & Families for TSN Gene

Gene Families for TSN Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TSN Gene

Blocks:
  • Translin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSN Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ34596 fis, clone KIDNE2009191, highly similar to TRANSLIN (B3KRM8_HUMAN)
  • cDNA FLJ55086, highly similar to Translin (B7Z3X8_HUMAN)
  • cDNA FLJ59957, highly similar to Translin (B7Z5D9_HUMAN)
  • Translin (TSN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15631

UniProtKB/Swiss-Prot:

TSN_HUMAN :
  • Belongs to the translin family.
Family:
  • Belongs to the translin family.
genes like me logo Genes that share domains with TSN: view

Function for TSN Gene

Molecular function for TSN Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
UniProtKB/Swiss-Prot Function:
Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
GENATLAS Biochemistry:
translin,recombinational hot spot protein,expressed in brain and testis,dimerizing DNA binding protein at the breakpoint junctions in chromosomal translocations,involved in DNA damage repair and in mRNA transport

Enzyme Numbers (IUBMB) for TSN Gene

Phenotypes From GWAS Catalog for TSN Gene

Gene Ontology (GO) - Molecular Function for TSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 7663511
GO:0003697 single-stranded DNA binding IBA 21873635
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IEA --
GO:0004518 nuclease activity IEA --
genes like me logo Genes that share ontologies with TSN: view
genes like me logo Genes that share phenotypes with TSN: view

Animal Models for TSN Gene

MGI Knock Outs for TSN:
  • Tsn Tsn<tm1Jmat>

Animal Model Products

  • Taconic Biosciences Mouse Models for TSN

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSN

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSN Gene

Localization for TSN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSN Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSN gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TSN: view

Pathways & Interactions for TSN Gene

PathCards logo

SuperPathways for TSN Gene

genes like me logo Genes that share pathways with TSN: view

Pathways by source for TSN Gene

Gene Ontology (GO) - Biological Process for TSN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination TAS 7663511
GO:0016070 RNA metabolic process IEA --
GO:0030422 production of siRNA involved in RNA interference TAS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with TSN: view

No data available for SIGNOR curated interactions for TSN Gene

Drugs & Compounds for TSN Gene

(1) Drugs for TSN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TSN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TSN: view

Transcripts for TSN Gene

mRNA/cDNA for TSN Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSN

Alternative Splicing Database (ASD) splice patterns (SP) for TSN Gene

No ASD Table

Relevant External Links for TSN Gene

GeneLoc Exon Structure for
TSN

Expression for TSN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSN Gene



Protein tissue co-expression partners for TSN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSN

SOURCE GeneReport for Unigene cluster for TSN Gene:

Hs.75066

Evidence on tissue expression from TISSUES for TSN Gene

  • Nervous system(4.9)
  • Lung(4.4)
  • Kidney(2.3)
  • Liver(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TSN: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSN Gene

Orthologs for TSN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TSN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSN 31 30
  • 99.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TSN 31 30
  • 94.88 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSN 31
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSN 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSN 31 30
  • 91.67 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tsn 30
  • 90.64 (n)
mouse
(Mus musculus)
Mammalia Tsn 17 31 30
  • 90.2 (n)
chicken
(Gallus gallus)
Aves TSN 31 30
  • 77.78 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSN 31
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mllt4 30
  • 71.85 (n)
African clawed frog
(Xenopus laevis)
Amphibia tsn-prov 30
zebrafish
(Danio rerio)
Actinopterygii tsn 31 30
  • 71.28 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10580 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005538 30
  • 54.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta trsn 31 30
  • 53.27 (n)
OneToOne
CG11761 32
  • 52 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37020 30
  • 52.18 (n)
rice
(Oryza sativa)
Liliopsida Os10g0443200 30
  • 47.08 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tsn1 30
  • 49.83 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06664 30
  • 46.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
OneToOne
Species where no ortholog for TSN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSN Gene

ENSEMBL:
Gene Tree for TSN (if available)
TreeFam:
Gene Tree for TSN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSN: view image

Paralogs for TSN Gene

Paralogs for TSN Gene

Pseudogenes.org Pseudogenes for TSN Gene

genes like me logo Genes that share paralogs with TSN: view

Variants for TSN Gene

Additional dbSNP identifiers (rs#s) for TSN Gene

Structural Variations from Database of Genomic Variants (DGV) for TSN Gene

Variant ID Type Subtype PubMed ID
esv3592209 CNV gain 21293372
esv3592217 CNV gain 21293372
nsv1011665 CNV gain 25217958
nsv459163 CNV gain 19166990
nsv582808 CNV gain 21841781
nsv834351 CNV loss 17160897

Variation tolerance for TSN Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSN Gene

Disorders for TSN Gene

MalaCards: The human disease database

(4) MalaCards diseases for TSN Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TSN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TSN

genes like me logo Genes that share disorders with TSN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSN Gene

Publications for TSN Gene

  1. Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein. (PMID: 9244443) Aoki K … Kasai M (Genomics 1997) 2 3 4 23 54
  2. The translin ring specifically recognizes DNA ends at recombination hot spots in the human genome. (PMID: 9111049) Kasai M … Suzuki K (The Journal of biological chemistry 1997) 3 4 23 54
  3. A novel gene, Translin, encodes a recombination hotspot binding protein associated with chromosomal translocations. (PMID: 7663511) Aoki K … Kasai M (Nature genetics 1995) 3 4 23 54
  4. Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11). (PMID: 7947454) Kasai M … Strominger JL (International immunology 1994) 2 3 23 54
  5. Structure of C3PO and mechanism of human RISC activation. (PMID: 21552258) Ye X … Zhang H (Nature structural & molecular biology 2011) 3 4 54

Products for TSN Gene

Sources for TSN Gene