External Ids for TSLP Gene
Previous GeneCards Identifiers for TSLP Gene
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]
GeneCards Summary for TSLP Gene
TSLP (Thymic Stromal Lymphopoietin) is a Protein Coding gene. Diseases associated with TSLP include Eczema Herpeticum and Allergic Asthma. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Development and heterogeneity of the ILC family. Gene Ontology (GO) annotations related to this gene include cytokine activity.
UniProtKB/Swiss-Prot Summary for TSLP Gene
[Isoform 1]: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.
[Isoform 2]: May act as an antimicrobial peptide in the oral cavity and on the skin.