Aliases for TSKU Gene

Aliases for TSKU Gene

  • Tsukushi, Small Leucine Rich Proteoglycan 2 3 5
  • Tsukushin 2 3 4
  • Leucine-Rich Repeat-Containing Protein 54 3 4
  • Leucine Rich Repeat Containing 54 2 3
  • E2-Induced Gene 4 Protein 3 4
  • LRRC54 3 4
  • E2IG4 3 4
  • TSK 3 4
  • Tsukushi Small Leucine Rich Proteoglycan Homolog (Xenopus Laevis) 2
  • Tsukushi Small Leucine Rich Proteoglycan Homolog 3
  • Tsukushi Homolog 3
  • Tsukushi 4

External Ids for TSKU Gene

Previous HGNC Symbols for TSKU Gene

  • LRRC54

Previous GeneCards Identifiers for TSKU Gene

  • GC11P076171
  • GC11P076494
  • GC11P072791

Summaries for TSKU Gene

GeneCards Summary for TSKU Gene

TSKU (Tsukushi, Small Leucine Rich Proteoglycan) is a Protein Coding gene. Diseases associated with TSKU include Barre-Lieou Syndrome and Spondylolisthesis. Among its related pathways are Ectoderm Differentiation. An important paralog of this gene is IGFALS.

Additional gene information for TSKU Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSKU Gene

Genomics for TSKU Gene

GeneHancer (GH) Regulatory Elements for TSKU Gene

Promoters and enhancers for TSKU Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSKU on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSKU

Top Transcription factor binding sites by QIAGEN in the TSKU gene promoter:
  • AP-1
  • AREB6
  • COUP
  • COUP-TF
  • COUP-TF1
  • Egr-4
  • Evi-1
  • GATA-1
  • GATA-2
  • Nkx5-1

Genomic Locations for TSKU Gene

Genomic Locations for TSKU Gene
chr11:76,782,251-76,798,154
(GRCh38/hg38)
Size:
15,904 bases
Orientation:
Plus strand
chr11:76,493,295-76,509,198
(GRCh37/hg19)
Size:
15,904 bases
Orientation:
Plus strand

Genomic View for TSKU Gene

Genes around TSKU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSKU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSKU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSKU Gene

Proteins for TSKU Gene

  • Protein details for TSKU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUA8-TSK_HUMAN
    Recommended name:
    Tsukushin
    Protein Accession:
    Q8WUA8
    Secondary Accessions:
    • B3KQT7
    • Q6UXK1
    • Q9UG10
    • Q9UJX9

    Protein attributes for TSKU Gene

    Size:
    353 amino acids
    Molecular mass:
    37807 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSKU Gene

Post-translational modifications for TSKU Gene

  • Glycosylation at Asn74, Asn137, Thr152, Thr153, and Ser248
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSKU Gene

Domains & Families for TSKU Gene

Gene Families for TSKU Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for TSKU Gene

Blocks:
  • Cysteine-rich flanking region, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSKU Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 54 (TSK_HUMAN)
genes like me logo Genes that share domains with TSKU: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TSKU Gene

Function for TSKU Gene

Molecular function for TSKU Gene

UniProtKB/Swiss-Prot Induction:
By 17-beta-estradiol.

Phenotypes From GWAS Catalog for TSKU Gene

genes like me logo Genes that share phenotypes with TSKU: view

Animal Models for TSKU Gene

MGI Knock Outs for TSKU:
  • Tsku Tsku<tm1Koth>

Animal Model Products

  • Taconic Biosciences Mouse Models for TSKU

CRISPR Products

miRNA for TSKU Gene

miRTarBase miRNAs that target TSKU

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TSKU Gene

Localization for TSKU Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSKU Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSKU gene
Compartment Confidence
extracellular 4
plasma membrane 2
nucleus 2
cytosol 2
lysosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSKU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with TSKU: view

Pathways & Interactions for TSKU Gene

PathCards logo

SuperPathways for TSKU Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with TSKU: view

Pathways by source for TSKU Gene

1 BioSystems pathway for TSKU Gene

Gene Ontology (GO) - Biological Process for TSKU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IEA --
GO:0021540 corpus callosum morphogenesis IEA --
GO:0021670 lateral ventricle development IEA --
GO:0021960 anterior commissure morphogenesis IEA --
GO:0030178 negative regulation of Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TSKU: view

No data available for SIGNOR curated interactions for TSKU Gene

Drugs & Compounds for TSKU Gene

No Compound Related Data Available

Transcripts for TSKU Gene

mRNA/cDNA for TSKU Gene

5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSKU Gene

No ASD Table

Relevant External Links for TSKU Gene

GeneLoc Exon Structure for
TSKU

Expression for TSKU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSKU Gene

mRNA differential expression in normal tissues according to GTEx for TSKU Gene

This gene is overexpressed in Liver (x5.8) and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for TSKU Gene

This gene is overexpressed in Plasma (54.7) and Placenta (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TSKU Gene



Protein tissue co-expression partners for TSKU Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSKU

SOURCE GeneReport for Unigene cluster for TSKU Gene:

Hs.8361

Evidence on tissue expression from TISSUES for TSKU Gene

  • Intestine(4.6)
  • Skin(3.6)
  • Nervous system(3.1)
  • Heart(2.5)
  • Lung(2)
genes like me logo Genes that share expression patterns with TSKU: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSKU Gene

Orthologs for TSKU Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSKU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSKU 31 30
  • 98.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TSKU 31 30
  • 86.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tsku 17 31 30
  • 82.43 (n)
rat
(Rattus norvegicus)
Mammalia Tsku 30
  • 81.42 (n)
cow
(Bos Taurus)
Mammalia TSKU 31
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TSKU 31
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TSKU 31
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TSKU 31 30
  • 60.12 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TSKU 31
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tsku 30
  • 58.95 (n)
zebrafish
(Danio rerio)
Actinopterygii tsku 31 30
  • 54.05 (n)
OneToOne
wufd51d02 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2453 30
Species where no ortholog for TSKU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSKU Gene

ENSEMBL:
Gene Tree for TSKU (if available)
TreeFam:
Gene Tree for TSKU (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSKU: view image

Paralogs for TSKU Gene

genes like me logo Genes that share paralogs with TSKU: view

Variants for TSKU Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSKU Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11236938 - p.Ser248Asn
rs1149621 - p.Asp344Glu
rs3740771 - p.Val308Ile
rs3740772 - p.Arg208Cys

Additional dbSNP identifiers (rs#s) for TSKU Gene

Variation tolerance for TSKU Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSKU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSKU

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TSKU Gene

Disorders for TSKU Gene

MalaCards: The human disease database

(4) MalaCards diseases for TSKU Gene - From: DISEASES

Disorder Aliases PubMed IDs
barre-lieou syndrome
  • cervicocranial syndrome
spondylolisthesis
dental anomalies and short stature
  • dass
cauda equina syndrome
  • polyradiculopathy
- elite association - COSMIC cancer census association via MalaCards
Search TSKU in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TSKU

genes like me logo Genes that share disorders with TSKU: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSKU Gene

Publications for TSKU Gene

  1. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PMID: 11085516) Charpentier AH … Aldaz CM (Cancer research 2000) 2 3 4 54
  2. Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer. (PMID: 22880013) Henke A … Thomson AA (PloS one 2012) 2 3 54
  3. Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. (PMID: 19710929) Rakhshandehroo M … Kersten S (PloS one 2009) 2 3 54
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for TSKU Gene

  • Signalway ELISA kits for TSKU
  • Signalway Proteins for TSKU

Sources for TSKU Gene