This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathway... See more...

Aliases for TSKS Gene

Aliases for TSKS Gene

  • Testis Specific Serine Kinase Substrate 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 161 2 3
  • Testis-Specific Serine Kinase Substrate 3 4
  • Testis-Specific Kinase Substrate 3 4
  • STK22 Substrate 1 3 4
  • PPP1R161 2 3
  • STK22S1 3 4
  • TSKS1 3 4
  • TSSKS 2 3
  • Testis Specific Serine/Threonine Kinase Substrate 3
  • TSKS 5

External Ids for TSKS Gene

Previous GeneCards Identifiers for TSKS Gene

  • GC19M050901
  • GC19M050611
  • GC19M054919
  • GC19M054934
  • GC19M050243
  • GC19M046619

Summaries for TSKS Gene

Entrez Gene Summary for TSKS Gene

  • This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSKS Gene

TSKS (Testis Specific Serine Kinase Substrate) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot Summary for TSKS Gene

  • May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSKS Gene

Genomics for TSKS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TSKS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049761 Enhancer 1 ENCODE dbSUPER 628 +1.1 1067 2.1 ARHGAP35 CTCF PRDM10 ZNF512 IKZF1 JUND PRDM1 MTA2 ZIC2 PKNOX1 TSKS POLD1 NUP62 PTOV1-AS2 SNORD35A ADM5 CPT1C PRMT1 SNORD35B PNKP
GH19J049763 Promoter/Enhancer 0.6 EPDnew Ensembl 600.7 -0.3 -272 0.4 PRDM10 RF00026-511 RNU6-841P TSKS AP2A1
GH19J049816 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 -55.4 -55417 5 ZNF221 SP1 CREB1 TEAD4 PRDM10 RFX1 SIX5 IKZF1 RFX5 ZNF692 MED25 FUZ lnc-FUZ-1 PRR12 NUP62 POLD1 PTOV1-AS2 PNKP PTOV1 SNRNP70
GH19J049812 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -50.1 -50137 3 SP1 CTCF TEAD4 PRDM10 REST ZNF512 RFX1 SIX5 ZNF692 ZHX2 FUZ PRMT1 PTOV1 ADM5 CPT1C TSKS AP2A1 PTOV1-AS2 PTOV1-AS1 PTH2
GH19J049771 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.3 -11.0 -10952 5.8 GATAD2A ZBTB33 IKZF1 KDM1A GABPA MTA2 PHF21A ZIC2 RBFOX2 ZNF24 AKT1S1 PRR12 NUP62 AP2A1 TSKS MED25 FUZ PNKP VRK3 BCL2L12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSKS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSKS

Top Transcription factor binding sites by QIAGEN in the TSKS gene promoter:
  • Arnt
  • c-Ets-1
  • Egr-1
  • HNF-4alpha1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • Olf-1
  • Pax-4a

Genomic Locations for TSKS Gene

Genomic Locations for TSKS Gene
chr19:49,739,753-49,763,328
(GRCh38/hg38)
Size:
23,576 bases
Orientation:
Minus strand
chr19:50,243,010-50,266,587
(GRCh37/hg19)
Size:
23,578 bases
Orientation:
Minus strand

Genomic View for TSKS Gene

Genes around TSKS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSKS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSKS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSKS Gene

Proteins for TSKS Gene

  • Protein details for TSKS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT2-TSKS_HUMAN
    Recommended name:
    Testis-specific serine kinase substrate
    Protein Accession:
    Q9UJT2
    Secondary Accessions:
    • Q8WXJ0

    Protein attributes for TSKS Gene

    Size:
    592 amino acids
    Molecular mass:
    65050 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSKS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSKS Gene

Post-translational modifications for TSKS Gene

  • Phosphorylated on serine residue(s) by STK22A/TSSK1 and STK22B/TSSK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSKS Gene

No data available for DME Specific Peptides for TSKS Gene

Domains & Families for TSKS Gene

Gene Families for TSKS Gene

Protein Domains for TSKS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSKS Gene

GenScript: Design optimal peptide antigens:
  • STK22 substrate 1 (TSKS_HUMAN)
genes like me logo Genes that share domains with TSKS: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TSKS Gene

Function for TSKS Gene

Molecular function for TSKS Gene

UniProtKB/Swiss-Prot Function:
May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.

Phenotypes From GWAS Catalog for TSKS Gene

Gene Ontology (GO) - Molecular Function for TSKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15044604
GO:0019901 protein kinase binding IEA,IPI 18533145
genes like me logo Genes that share ontologies with TSKS: view
genes like me logo Genes that share phenotypes with TSKS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSKS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSKS Gene

Localization for TSKS Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSKS Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Concentrates in spermatid centrioles during flagellogenesis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSKS gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TSKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IBA,IDA 18495105
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TSKS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSKS Gene

Pathways & Interactions for TSKS Gene

PathCards logo

SuperPathways for TSKS Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSKS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with TSKS: view

No data available for Pathways by source and SIGNOR curated interactions for TSKS Gene

Drugs & Compounds for TSKS Gene

No Compound Related Data Available

Transcripts for TSKS Gene

mRNA/cDNA for TSKS Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TSKS

Alternative Splicing Database (ASD) splice patterns (SP) for TSKS Gene

No ASD Table

Relevant External Links for TSKS Gene

GeneLoc Exon Structure for
TSKS

Expression for TSKS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSKS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSKS Gene

This gene is overexpressed in Testis (x44.0).

Protein differential expression in normal tissues from HIPED for TSKS Gene

This gene is overexpressed in Testis (36.5), Ovary (16.6), and Liver, secretome (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSKS Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSKS

SOURCE GeneReport for Unigene cluster for TSKS Gene:

Hs.515858

mRNA Expression by UniProt/SwissProt for TSKS Gene:

Q9UJT2-TSKS_HUMAN
Tissue specificity: Highly expressed in testis. Expressed at low levels in prostate, female breast, placenta, ovary and thymus.

Evidence on tissue expression from TISSUES for TSKS Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TSKS: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSKS Gene

Orthologs for TSKS Gene

This gene was present in the common ancestor of chordates.

Orthologs for TSKS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TSKS 30 31
  • 99.14 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TSKS 30 31
  • 87.81 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tsks 30 17 31
  • 84.49 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tsks 30
  • 84.37 (n)
Dog
(Canis familiaris)
Mammalia TSKS 30 31
  • 83.86 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TSKS 31
  • 73 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TSKS 31
  • 43 (a)
OneToOne
Species where no ortholog for TSKS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TSKS Gene

ENSEMBL:
Gene Tree for TSKS (if available)
TreeFam:
Gene Tree for TSKS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TSKS: view image

Paralogs for TSKS Gene

No data available for Paralogs for TSKS Gene

Variants for TSKS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSKS Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs149529240 A colorectal cancer sample p.Gly19Arg
rs2304202 - p.Asp382Gly
rs34701020 - p.Glu167Lys

Additional dbSNP identifiers (rs#s) for TSKS Gene

Structural Variations from Database of Genomic Variants (DGV) for TSKS Gene

Variant ID Type Subtype PubMed ID
dgv53n68 CNV loss 17160897
esv3382785 CNV insertion 20981092
esv3644627 CNV loss 21293372
nsv1109206 CNV deletion 24896259
nsv1116341 CNV deletion 24896259
nsv1160655 CNV deletion 26073780
nsv470150 CNV gain 18288195
nsv478624 CNV novel sequence insertion 20440878
nsv953600 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for TSKS Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.20; 87.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSKS Gene

Human Gene Mutation Database (HGMD)
TSKS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSKS

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSKS Gene

Disorders for TSKS Gene

No disorders were found for TSKS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSKS Gene

Publications for TSKS Gene

  1. Identification and characterization of a novel human testis-specific kinase substrate gene which is downregulated in testicular tumors. (PMID: 11444856) Scorilas A … Diamandis EP (Biochemical and biophysical research communications 2001) 2 3 4 23
  2. TSKS concentrates in spermatid centrioles during flagellogenesis. (PMID: 18495105) Xu B … Herr JC (Developmental biology 2008) 2 3 4
  3. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. (PMID: 15044604) Hao Z … Visconti PE (Molecular human reproduction 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for TSKS Gene

Sources for TSKS Gene