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Aliases for TSIX Gene

Subcategory (RNA class) for TSIX Gene


Quality Score for this RNA gene is


Aliases for TSIX Gene

  • TSIX Transcript, XIST Antisense RNA 2 3 5
  • TSIX Transcript, XIST Antisense RNA (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 13 2 3
  • XIST Antisense RNA (Non-Protein Coding) 2 3
  • X (Inactive)-Specific Transcript, Antisense (Non-Protein Coding) 3
  • X-Inactivation-Specific Transcript-Antisense 3
  • X (Inactive)-Specific Transcript, Antisense 2
  • NCRNA00013 3
  • LINC00013 3
  • XIST-AS1 3
  • XIST-AS 3
  • XISTAS 3

External Ids for TSIX Gene

ORGUL Members for TSIX Gene

Previous GeneCards Identifiers for TSIX Gene

  • GC0XU990273
  • GC0XP073013

Summaries for TSIX Gene

Entrez Gene Summary for TSIX Gene

  • In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSIX Gene

TSIX (TSIX Transcript, XIST Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for TSIX Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSIX Gene

Genomics for TSIX Gene

GeneHancer (GH) Regulatory Elements for TSIX Gene

Top Transcription factor binding sites by QIAGEN in the TSIX gene promoter:

Genomic Locations for TSIX Gene

Genomic Locations for TSIX Gene
37,027 bases
Plus strand

Genomic View for TSIX Gene

Genes around TSIX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSIX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSIX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSIX Gene

Proteins for TSIX Gene

Post-translational modifications for TSIX Gene

No Post-translational modifications

No data available for DME Specific Peptides for TSIX Gene

Domains & Families for TSIX Gene

Gene Families for TSIX Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TSIX: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TSIX Gene

Function for TSIX Gene

Molecular function for TSIX Gene

GENATLAS Biochemistry:
gene antisense to XIST,involved in the early steps of X-inactivation

Phenotypes for TSIX Gene

genes like me logo Genes that share phenotypes with TSIX: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSIX Gene

Localization for TSIX Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSIX gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TSIX Gene

Pathways & Interactions for TSIX Gene

No Data Available

Interacting Proteins for TSIX Gene

Gene Ontology (GO) - Biological Process for TSIX Gene


No data available for Pathways by source and SIGNOR curated interactions for TSIX Gene

Drugs & Compounds for TSIX Gene

No Compound Related Data Available

Transcripts for TSIX Gene

mRNA/cDNA for TSIX Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TSIX Gene

No ASD Table

Relevant External Links for TSIX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSIX Gene

NURSA nuclear receptor signaling pathways regulating expression of TSIX Gene:

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSIX Gene

Orthologs for TSIX Gene

Evolution for TSIX Gene

Gene Tree for TSIX (if available)
Gene Tree for TSIX (if available)

No data available for Orthologs for TSIX Gene

Paralogs for TSIX Gene

No data available for Paralogs for TSIX Gene

Variants for TSIX Gene

Sequence variations from dbSNP and Humsavar for TSIX Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000056301 -- 73,790,553(+) T/C upstream_transcript_variant
rs1000146909 -- 73,806,323(+) C/T non_coding_transcript_variant
rs1000477310 -- 73,825,179(+) T/C non_coding_transcript_variant
rs1000746171 -- 73,804,521(+) G/A non_coding_transcript_variant
rs1000900258 -- 73,808,303(+) C/T non_coding_transcript_variant

Additional Variant Information for TSIX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TSIX Gene

Disorders for TSIX Gene

Additional Disease Information for TSIX

No disorders were found for TSIX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSIX Gene

Publications for TSIX Gene

  1. Tsix, a gene antisense to Xist at the X-inactivation centre. (PMID: 10192391) Lee JT … Warshawsky D (Nature genetics 1999) 2 3 22 58
  2. CTCF, a candidate trans-acting factor for X-inactivation choice. (PMID: 11743158) Chao W … Lee JT (Science (New York, N.Y.) 2002) 3 22 58
  3. Long non-coding RNA TSIX is upregulated in scleroderma dermal fibroblasts and controls collagen mRNA stabilization. (PMID: 26566700) Wang Z … Ihn H (Experimental dermatology 2016) 3 58
  4. A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation. (PMID: 25981039) Gayen S … Kalantry S (Cell reports 2015) 3 58
  5. X chromosome inactivation sparked by non-coding RNAs. (PMID: 19246991) Leeb M … Wutz A (RNA biology 2009) 22 58

Products for TSIX Gene

Sources for TSIX Gene

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