Aliases for TSHZ3 Gene
External Ids for TSHZ3 Gene
Previous HGNC Symbols for TSHZ3 Gene
Previous GeneCards Identifiers for TSHZ3 Gene
This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016]
GeneCards Summary for TSHZ3 Gene
TSHZ3 (Teashirt Zinc Finger Homeobox 3) is a Protein Coding gene. Diseases associated with TSHZ3 include Hydronephrosis and Endemic Goiter. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is TSHZ1.
UniProtKB/Swiss-Prot Summary for TSHZ3 Gene
Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).