Aliases for TSHB Gene
External Ids for TSHB Gene
Previous GeneCards Identifiers for TSHB Gene
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
GeneCards Summary for TSHB Gene
TSHB (Thyroid Stimulating Hormone Subunit Beta) is a Protein Coding gene. Diseases associated with TSHB include Hypothyroidism, Congenital, Nongoitrous, 4 and Central Congenital Hypothyroidism. Among its related pathways are Aldosterone synthesis and secretion and Amine-derived hormones. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is LHB.
UniProtKB/Swiss-Prot Summary for TSHB Gene
Indispensable for the control of thyroid structure and metabolism.