Aliases for TSGA10 Gene

Aliases for TSGA10 Gene

  • Testis Specific 10 2 3 5
  • Testis Development Protein NYD-SP7 3 4
  • Testis-Specific Gene 10 Protein 3 4
  • Cancer/Testis Antigen 79 2 3
  • CEP4L 3 4
  • Testis-Specific 10 Protein 3
  • SPGF26 3
  • CT79 3

External Ids for TSGA10 Gene

Previous GeneCards Identifiers for TSGA10 Gene

  • GC02M097495
  • GC02M098066
  • GC02M099218
  • GC02M099235
  • GC02M099072
  • GC02M099613
  • GC02M093379

Summaries for TSGA10 Gene

GeneCards Summary for TSGA10 Gene

TSGA10 (Testis Specific 10) is a Protein Coding gene. Diseases associated with TSGA10 include Spermatogenic Failure 26 and Autoimmune Polyendocrine Syndrome Type 1. An important paralog of this gene is CEP135.

UniProtKB/Swiss-Prot Summary for TSGA10 Gene

  • Plays a role in spermatogenesis (PubMed:28905369). When overexpressed, prevents nuclear localization of HIF1A (By similarity).

Additional gene information for TSGA10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TSGA10 Gene

Genomics for TSGA10 Gene

GeneHancer (GH) Regulatory Elements for TSGA10 Gene

Promoters and enhancers for TSGA10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TSGA10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TSGA10

Top Transcription factor binding sites by QIAGEN in the TSGA10 gene promoter:
  • aMEF-2
  • AML1a
  • Egr-4
  • MEF-2A
  • Pax-4a
  • Pax-5
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • S8

Genomic Locations for TSGA10 Gene

Genomic Locations for TSGA10 Gene
157,704 bases
Minus strand
157,704 bases
Minus strand

Genomic View for TSGA10 Gene

Genes around TSGA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSGA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSGA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSGA10 Gene

Proteins for TSGA10 Gene

  • Protein details for TSGA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific gene 10 protein
    Protein Accession:
    Secondary Accessions:
    • B7Z925
    • D3DVH7
    • Q8NEP0
    • Q9BWX0

    Protein attributes for TSGA10 Gene

    698 amino acids
    Molecular mass:
    81421 Da
    Quaternary structure:
    • Interacts with HIF1A.

    Alternative splice isoforms for TSGA10 Gene


neXtProt entry for TSGA10 Gene

Post-translational modifications for TSGA10 Gene

  • Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSGA10 Gene

Domains & Families for TSGA10 Gene

Gene Families for TSGA10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSGA10 Gene


Suggested Antigen Peptide Sequences for TSGA10 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55754, highly similar to Homo sapiens testis specific, 10 (TSGA10), mRNA (B7Z925_HUMAN)
  • Testis development protein NYD-SP7 (TSG10_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CEP135/TSGA10 family.
  • Belongs to the CEP135/TSGA10 family.
genes like me logo Genes that share domains with TSGA10: view

Function for TSGA10 Gene

Molecular function for TSGA10 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in spermatogenesis (PubMed:28905369). When overexpressed, prevents nuclear localization of HIF1A (By similarity).

Phenotypes From GWAS Catalog for TSGA10 Gene

Gene Ontology (GO) - Molecular Function for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TSGA10: view
genes like me logo Genes that share phenotypes with TSGA10: view

Human Phenotype Ontology for TSGA10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for TSGA10 Gene

miRTarBase miRNAs that target TSGA10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TSGA10 Gene

Localization for TSGA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSGA10 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In mature spermatozoa, localizes to the centriole and midpiece (PubMed:28905369). The 27-kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa peptide localizes to the midpiece (By similarity). Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (By similarity). {ECO:0000250 UniProtKB:Q9Z220, ECO:0000269 PubMed:28905369}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSGA10 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA --
GO:0005856 cytoskeleton IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with TSGA10: view

Pathways & Interactions for TSGA10 Gene

PathCards logo

SuperPathways for TSGA10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS,IEA 11179690
GO:0030031 cell projection assembly IEA --
genes like me logo Genes that share ontologies with TSGA10: view

No data available for Pathways by source and SIGNOR curated interactions for TSGA10 Gene

Drugs & Compounds for TSGA10 Gene

No Compound Related Data Available

Transcripts for TSGA10 Gene

mRNA/cDNA for TSGA10 Gene

16 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSGA10 Gene

No ASD Table

Relevant External Links for TSGA10 Gene

GeneLoc Exon Structure for

Expression for TSGA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TSGA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSGA10 Gene

This gene is overexpressed in Testis (x13.5).

Protein differential expression in normal tissues from HIPED for TSGA10 Gene

This gene is overexpressed in Nasal epithelium (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TSGA10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TSGA10

SOURCE GeneReport for Unigene cluster for TSGA10 Gene:


mRNA Expression by UniProt/SwissProt for TSGA10 Gene:

Tissue specificity: Expressed in the testis, in spermatozoa (at protein level) (PubMed:11179690, PubMed:28905369). Expressed in actively dividing fetal tissues, including sternum, intestine, limb, kidney and stomach (PubMed:14585816).
genes like me logo Genes that share expression patterns with TSGA10: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSGA10 Gene

Orthologs for TSGA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSGA10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSGA10 31 30
  • 99.62 (n)
(Canis familiaris)
Mammalia TSGA10 31 30
  • 94.61 (n)
(Bos Taurus)
Mammalia TSGA10 31 30
  • 93.28 (n)
(Mus musculus)
Mammalia Tsga10 17 31 30
  • 89 (n)
(Rattus norvegicus)
Mammalia Tsga10 30
  • 88.59 (n)
(Monodelphis domestica)
Mammalia TSGA10 31
  • 85 (a)
(Gallus gallus)
Aves TSGA10 31 30
  • 65.17 (n)
(Anolis carolinensis)
Reptilia TSGA10 31
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tsga10 30
  • 60.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398577 30
(Danio rerio)
Actinopterygii tsga10 31 30
  • 51.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cep135 31
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
Species where no ortholog for TSGA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSGA10 Gene

Gene Tree for TSGA10 (if available)
Gene Tree for TSGA10 (if available)
Evolutionary constrained regions (ECRs) for TSGA10: view image

Paralogs for TSGA10 Gene

Paralogs for TSGA10 Gene

(1) SIMAP similar genes for TSGA10 Gene using alignment to 4 proteins:

  • B7Z925_HUMAN
  • F8WA32_HUMAN
genes like me logo Genes that share paralogs with TSGA10: view

Variants for TSGA10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TSGA10 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
708463 Benign: not provided 99,065,002(-) A/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
717144 Benign: not provided 99,071,838(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
734295 Likely Benign: not provided 99,105,551(-) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
773485 Benign: not provided 99,068,884(-) A/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for TSGA10 Gene

Structural Variations from Database of Genomic Variants (DGV) for TSGA10 Gene

Variant ID Type Subtype PubMed ID
esv2538757 CNV insertion 19546169
esv2720430 CNV deletion 23290073
esv2898 CNV loss 18987735
esv3306754 CNV mobile element insertion 20981092
esv3432571 CNV insertion 20981092
esv3559835 CNV deletion 23714750
esv3591732 CNV gain 21293372
esv8179 CNV loss 19470904
esv993745 OTHER inversion 20482838
nsv1071607 CNV deletion 25765185
nsv1138821 CNV deletion 24896259
nsv214239 CNV deletion 16902084
nsv2844 CNV deletion 18451855
nsv834310 CNV gain+loss 17160897
nsv954728 CNV deletion 24416366

Variation tolerance for TSGA10 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSGA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSGA10 Gene

Disorders for TSGA10 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TSGA10 Gene - From: OMIM, ClinVar, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
spermatogenic failure 26
  • spgf26
autoimmune polyendocrine syndrome type 1
  • autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
autoimmune polyendocrine syndrome
  • autoimmune polyendocrinopathy
  • digitate dermatosis
gemistocytic astrocytoma
  • gemistocytic astrocytic tumor
- elite association - COSMIC cancer census association via MalaCards


  • Spermatogenic failure 26 (SPGF26) [MIM:617961]: An autosomal recessive infertility disorder caused by spermatogenesis defects that result in acephalic spermatozoa. {ECO:0000269 PubMed:28905369}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TSGA10

genes like me logo Genes that share disorders with TSGA10: view

No data available for Genatlas for TSGA10 Gene

Publications for TSGA10 Gene

  1. Identification and characterisation of a novel gene, TSGA10, expressed in testis. (PMID: 11179690) Modarressi MH … Wolfe J (Gene 2001) 2 3 4 54
  2. TSGA10 is a novel candidate gene associated with acephalic spermatozoa. (PMID: 28905369) Sha YW … Li L (Clinical genetics 2018) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Over-expression of the testis-specific gene TSGA10 in cancers and its immunogenicity. (PMID: 15107545) Tanaka R … Nakayama E (Microbiology and immunology 2004) 3 23 54
  5. Contribution and prognostic value of TSGA10 gene expression in patients with acute myeloid leukemia (AML). (PMID: 30638859) Hoseinkhani Z … Mansouri K (Pathology, research and practice 2019) 3 54

Products for TSGA10 Gene

Sources for TSGA10 Gene