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TSGA10 Gene(Protein Coding)

Testis Specific 10

GCID:
GC02M099072
GIFtS:
40
Genes Participants
UDN Logo

Aliases for TSGA10 Gene

Aliases for TSGA10 Gene

  • Testis Specific 10 2 3 5
  • Testis Development Protein NYD-SP7 3 4
  • Cancer/Testis Antigen 79 2 3
  • CEP4L 3 4
  • Testis-Specific Gene 10 Protein 3
  • Testis-Specific 10 Protein 3
  • CT79 3

External Ids for TSGA10 Gene

Previous GeneCards Identifiers for TSGA10 Gene

  • GC02M097495
  • GC02M098066
  • GC02M099218
  • GC02M099235
  • GC02M099613
  • GC02M093379

Summaries for TSGA10 Gene

GeneCards Summary for TSGA10 Gene

TSGA10 (Testis Specific 10) is a Protein Coding gene. An important paralog of this gene is CEP135.

UniProtKB/Swiss-Prot for TSGA10 Gene

  • May play a role in the sperm tail fibrous sheath, a major sperm tail structure.

Additional gene information for TSGA10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSGA10 Gene

Genomics for TSGA10 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TSGA10 Gene

Promoters and enhancers for TSGA10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02I099152 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 603.2 +0.8 804 4.2 HDGF CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 TSGA10 LIPT1 ENSG00000273155 REV1 MRPL30 ENSG00000241962 C2orf15
GH02I099140 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 602.6 +13.6 13639 2.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 SP3 TSGA10 ENSG00000241962 C2orf15 LOC550644
GH02I099179 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 71.2 -26.6 -26572 3.4 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MITD1 MRPL30 TSGA10 UNC50 REV1 LIPT1 ENSG00000273306 LOC550644 ENSG00000241962 LYG1
GH02I099065 Enhancer 0.9 Ensembl ENCODE 42.4 +88.5 88546 1.9 CTCF ARID4B ZNF644 RAD21 GATA3 ZNF143 SMC3 ETV6 IKZF2 RUNX3 TSGA10 LIPT1 MRPL30 LOC550644 KIAA1211L
GH02I099487 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 14.5 -334.5 -334542 3.4 PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 REV1 TSGA10 LYG1 ENSG00000273306
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSGA10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSGA10 gene promoter:

Genomic Locations for TSGA10 Gene

Genomic Locations for TSGA10 Gene
chr2:98,997,261-99,154,964
(GRCh38/hg38)
Size:
157,704 bases
Orientation:
Minus strand
chr2:99,613,724-99,771,427
(GRCh37/hg19)

Genomic View for TSGA10 Gene

Genes around TSGA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSGA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSGA10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TSGA10 Gene

Proteins for TSGA10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TSGA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZW7-TSG10_HUMAN
    Recommended name:
    Testis-specific gene 10 protein
    Protein Accession:
    Q9BZW7
    Secondary Accessions:
    • B7Z925
    • D3DVH7
    • Q8NEP0
    • Q9BWX0

    Protein attributes for TSGA10 Gene

    Size:
    698 amino acids
    Molecular mass:
    81421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TSGA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TSGA10 Gene

Protein Expression for TSGA10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TSGA10 Gene

  • Appears to be processed in a 27 kDa and a 55 kDa peptide containing respectively the N-terminal and the C-terminal part of the precursor.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TSGA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TSGA10 Gene

Domains & Families for TSGA10 Gene

Gene Families for TSGA10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSGA10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TSGA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZW7

UniProtKB/Swiss-Prot:

TSG10_HUMAN :
  • Belongs to the CEP135/TSGA10 family.
Family:
  • Belongs to the CEP135/TSGA10 family.
genes like me logo Genes that share domains with TSGA10: view

Function for TSGA10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TSGA10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the sperm tail fibrous sheath, a major sperm tail structure.

Phenotypes From GWAS Catalog for TSGA10 Gene

Gene Ontology (GO) - Molecular Function for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with TSGA10: view

Phenotypes for TSGA10 Gene

GenomeRNAi human phenotypes for TSGA10:
genes like me logo Genes that share phenotypes with TSGA10: view

Animal Model Products

miRNA for TSGA10 Gene

miRTarBase miRNAs that target TSGA10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSGA10 Gene

Localization for TSGA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSGA10 Gene

Cytoplasm. Nucleus. Nucleus membrane. Note=The 27 kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail while the 55 kDa peptide localizes to the midpiece. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSGA10 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0031514 motile cilium IEA --
genes like me logo Genes that share ontologies with TSGA10: view

Pathways & Interactions for TSGA10 Gene

SuperPathways for TSGA10 Gene

PathCards logo More details on SuperPathways for TSGA10
No Data Available

Gene Ontology (GO) - Biological Process for TSGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IEA,TAS 11179690
GO:0030031 cell projection assembly IEA --
genes like me logo Genes that share ontologies with TSGA10: view

No data available for Pathways by source and SIGNOR curated interactions for TSGA10 Gene

Drugs & Compounds for TSGA10 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TSGA10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TSGA10 Gene

(34) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TSGA10 Gene

Testis specific, 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSGA10 Gene

No ASD Table

Relevant External Links for TSGA10 Gene

GeneLoc Exon Structure for
TSGA10
ECgene alternative splicing isoforms for
TSGA10

Expression for TSGA10 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSGA10 Gene

mRNA expression in normal human tissues for TSGA10 Gene
mRNA expression by GTEx for TSGA10 GenemRNA expression by BioGPS for TSGA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TSGA10 Gene

This gene is overexpressed in Testis (x13.5).

Protein differential expression in normal tissues from HIPED for TSGA10 Gene

This gene is overexpressed in Nasal epithelium (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSGA10 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSGA10 Gene:

TSGA10

SOURCE GeneReport for Unigene cluster for TSGA10 Gene:

Hs.120267

mRNA Expression by UniProt/SwissProt for TSGA10 Gene:

Q9BZW7-TSG10_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with TSGA10: view

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSGA10 Gene

Orthologs for TSGA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSGA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TSGA10 33 34
  • 99.62 (n)
dog
(Canis familiaris)
 Mammalia TSGA10 33 34
  • 94.61 (n)
cow
(Bos Taurus)
 Mammalia TSGA10 33 34
  • 93.28 (n)
mouse
(Mus musculus)
 Mammalia Tsga10 33 16 34
  • 89 (n)
rat
(Rattus norvegicus)
 Mammalia Tsga10 33
  • 88.59 (n)
oppossum
(Monodelphis domestica)
 Mammalia TSGA10 34
  • 85 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TSGA10 33 34
  • 65.17 (n)
lizard
(Anolis carolinensis)
 Reptilia TSGA10 34
  • 59 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tsga10 33
  • 60.32 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC398577 33
zebrafish
(Danio rerio)
 Actinopterygii tsga10 33 34
  • 51.64 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Cep135 34
  • 12 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 22 (a)
 OneToMany
Species where no ortholog for TSGA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSGA10 Gene

ENSEMBL:
Gene Tree for TSGA10 (if available)
TreeFam:
Gene Tree for TSGA10 (if available)

Paralogs for TSGA10 Gene

Paralogs for TSGA10 Gene

(1) SIMAP similar genes for TSGA10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TSGA10: view

Variants for TSGA10 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for TSGA10 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs181470779 likely-benign, not specified 99,155,036(-) C/G/T upstream_transcript_variant
rs187804121 likely-benign, not specified 99,156,388(-) C/G/T upstream_transcript_variant
rs533919549 likely-benign, not specified 99,155,039(-) C/T upstream_transcript_variant
rs190816941 benign, not specified 99,156,389(-) G/A upstream_transcript_variant
rs2516828 benign, not specified 99,156,412(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSGA10 Gene

Variant ID Type Subtype PubMed ID
esv2538757 CNV insertion 19546169
esv2720430 CNV deletion 23290073
esv2898 CNV loss 18987735
esv3306754 CNV mobile element insertion 20981092
esv3432571 CNV insertion 20981092
esv3559835 CNV deletion 23714750
esv3591732 CNV gain 21293372
esv8179 CNV loss 19470904
esv993745 OTHER inversion 20482838
nsv1071607 CNV deletion 25765185
nsv1138821 CNV deletion 24896259
nsv214239 CNV deletion 16902084
nsv2844 CNV deletion 18451855
nsv834310 CNV gain+loss 17160897
nsv954728 CNV deletion 24416366

Variation tolerance for TSGA10 Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSGA10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSGA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSGA10 Gene

Disorders for TSGA10 Gene

Additional Disease Information for TSGA10

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TSGA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSGA10 Gene

Publications for TSGA10 Gene

  1. Identification and characterisation of a novel gene, TSGA10, expressed in testis. (PMID: 11179690) Modarressi MH … Wolfe J (Gene 2001) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Over-expression of the testis-specific gene TSGA10 in cancers and its immunogenicity. (PMID: 15107545) Tanaka R … Nakayama E (Microbiology and immunology 2004) 3 22 58
  4. TSGA10 is a novel candidate gene associated with acephalic spermatozoa. (PMID: 28905369) Sha YW … Li L (Clinical genetics 2018) 3 58
  5. Identification of new TSGA10 transcript variants in human testis with conserved regulatory RNA elements in 5'untranslated region and distinct expression in breast cancer. (PMID: 28739310) Salehipour P … Modarressi MH (Biochimica et biophysica acta 2017) 3 58

Products for TSGA10 Gene

Sources for TSGA10 Gene

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