Aliases for TSEN15 Gene
External Ids for TSEN15 Gene
Previous HGNC Symbols for TSEN15 Gene
Previous GeneCards Identifiers for TSEN15 Gene
This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014]
GeneCards Summary for TSEN15 Gene
TSEN15 (TRNA Splicing Endonuclease Subunit 15) is a Protein Coding gene. Diseases associated with TSEN15 include Pontocerebellar Hypoplasia, Type 2F and Primary Microcephaly. Among its related pathways are tRNA processing and Gene Expression. Gene Ontology (GO) annotations related to this gene include tRNA-intron endonuclease activity.
UniProtKB/Swiss-Prot Summary for TSEN15 Gene
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492).