Aliases for TSC22D3 Gene
External Ids for TSC22D3 Gene
Previous HGNC Symbols for TSC22D3 Gene
Previous GeneCards Identifiers for TSC22D3 Gene
This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
GeneCards Summary for TSC22D3 Gene
TSC22D3 (TSC22 Domain Family Member 3) is a Protein Coding gene. Diseases associated with TSC22D3 include Glucocorticoid-Induced Osteoporosis and Osteoporosis. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and MRF binding. An important paralog of this gene is TSC22D1.
UniProtKB/Swiss-Prot Summary for TSC22D3 Gene
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).