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Aliases for TSACC Gene

Aliases for TSACC Gene

  • TSSK6 Activating Cochaperone 2 3 5
  • SSTK-Interacting Protein 2 4
  • C1orf182 3 4
  • SSTK-IP 3 4
  • TSSK6-Activating Co-Chaperone Protein 3
  • Chromosome 1 Open Reading Frame 182 2
  • SSTK-Interacting Protein (SSTK-IP) 3
  • TSSK6 Activating Co-Chaperone 3
  • SIP 3

External Ids for TSACC Gene

Previous HGNC Symbols for TSACC Gene

  • C1orf182

Summaries for TSACC Gene

GeneCards Summary for TSACC Gene

TSACC (TSSK6 Activating Cochaperone) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for TSACC Gene

  • Co-chaperone that facilitates HSP-mediated activation of TSSK6.

Additional gene information for TSACC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSACC Gene

Genomics for TSACC Gene

GeneHancer (GH) Regulatory Elements for TSACC Gene

Promoters and enhancers for TSACC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I156336 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.7 738 2.9 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 CCT3 PIR53317 TSACC GLMP GON4L RRNAD1 KHDC4 MSTO2P ISG20L2 ENSG00000271267
GH01I156337 Enhancer 0.6 ENCODE 550.8 -0.8 -830 0.1 CTCF PKNOX1 TEAD4 MZF1 SIX5 BRD9 SCRT2 PRDM10 PIR55177 TSACC CCT3
GH01I156111 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.8 -215.9 -215925 19.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 LMNA GON4L CLK2 RRNAD1 KHDC4 LOC246784 MSTO1 MSTO2P PRCC ISG20L2
GH01I156740 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.4 +409.5 409548 13.6 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 HDGF MRPL24 KHDC4 GON4L RRNAD1 LOC246784 PRCC CCT3 SYT11 ISG20L2
GH01I156281 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 -54.1 -54056 4.4 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 SMG5 TMEM79 GLMP KHDC4 GON4L RRNAD1 YY1AP1 SLC25A44 PAQR6 BGLAP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSACC on UCSC Golden Path with GeneCards custom track

Genomic Locations for TSACC Gene

Genomic Locations for TSACC Gene
9,682 bases
Plus strand

Genomic View for TSACC Gene

Genes around TSACC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSACC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSACC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSACC Gene

Proteins for TSACC Gene

  • Protein details for TSACC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TSSK6-activating co-chaperone protein
    Protein Accession:
    Secondary Accessions:
    • D3DVB9

    Protein attributes for TSACC Gene

    125 amino acids
    Molecular mass:
    13670 Da
    Quaternary structure:
    • Interacts with HSP70. Associates with HSP90. Interacts with TSSK6; this interaction is direct and recruits TSACC to HSP90.

neXtProt entry for TSACC Gene

Post-translational modifications for TSACC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TSACC Gene

Domains & Families for TSACC Gene

Gene Families for TSACC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TSACC Gene


Suggested Antigen Peptide Sequences for TSACC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TSACC family.
  • Belongs to the TSACC family.
genes like me logo Genes that share domains with TSACC: view

Function for TSACC Gene

Molecular function for TSACC Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that facilitates HSP-mediated activation of TSSK6.

Phenotypes From GWAS Catalog for TSACC Gene

Gene Ontology (GO) - Molecular Function for TSACC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0051087 chaperone binding IPI 20829357
genes like me logo Genes that share ontologies with TSACC: view

Phenotypes for TSACC Gene

genes like me logo Genes that share phenotypes with TSACC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSACC

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TSACC Gene

Localization for TSACC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSACC gene
Compartment Confidence
extracellular 2
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TSACC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TSACC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TSACC Gene

Pathways & Interactions for TSACC Gene

SuperPathways for TSACC Gene

No Data Available

Interacting Proteins for TSACC Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96A04-TSACC_HUMAN ENSP00000357234 for TSACC Gene via MINT STRING IID UniProtKB

Gene Ontology (GO) - Biological Process for TSACC Gene


No data available for Pathways by source and SIGNOR curated interactions for TSACC Gene

Drugs & Compounds for TSACC Gene

No Compound Related Data Available

Transcripts for TSACC Gene

Unigene Clusters for TSACC Gene

TSSK6 activating co-chaperone:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSACC Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - -

Relevant External Links for TSACC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSACC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSACC Gene

mRNA differential expression in normal tissues according to GTEx for TSACC Gene

This gene is overexpressed in Testis (x50.3).

NURSA nuclear receptor signaling pathways regulating expression of TSACC Gene:


SOURCE GeneReport for Unigene cluster for TSACC Gene:


mRNA Expression by UniProt/SwissProt for TSACC Gene:

Tissue specificity: Expressed in testis but is absent from mature sperm.
genes like me logo Genes that share expression patterns with TSACC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSACC Gene

Orthologs for TSACC Gene

This gene was present in the common ancestor of mammals.

Orthologs for TSACC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1orf182 33 34
  • 98.93 (n)
(Bos Taurus)
Mammalia TSACC 33 34
  • 89.16 (n)
(Rattus norvegicus)
Mammalia Tsacc 33
  • 80.91 (n)
(Mus musculus)
Mammalia Tsacc 33 16 34
  • 75.54 (n)
(Monodelphis domestica)
Mammalia TSACC 34
  • 58 (a)
Species where no ortholog for TSACC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TSACC Gene

Gene Tree for TSACC (if available)
Gene Tree for TSACC (if available)

Paralogs for TSACC Gene

No data available for Paralogs for TSACC Gene

Variants for TSACC Gene

Sequence variations from dbSNP and Humsavar for TSACC Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000011592 -- 156,343,958(+) T/C intron_variant
rs1000311668 -- 156,344,330(+) T/C intron_variant
rs1000509068 -- 156,344,289(+) A/G intron_variant
rs1000662458 -- 156,343,928(+) C/T intron_variant
rs1000712347 -- 156,338,433(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSACC Gene

Variant ID Type Subtype PubMed ID
esv3587635 CNV gain 21293372

Variation tolerance for TSACC Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSACC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSACC Gene

Disorders for TSACC Gene

Additional Disease Information for TSACC

No disorders were found for TSACC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSACC Gene

Publications for TSACC Gene

  1. Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase. (PMID: 20829357) Jha KN … Johnson GR (The Journal of biological chemistry 2010) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58

Products for TSACC Gene

Sources for TSACC Gene

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