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Santos and Zasloff (1981) [PubMed 6261953] identified 12 initiator methionine tRNA genes, symbolized tRNA-i(met), in the haploid human genome. Zasloff et al. (1982) [PubMed 6923137] found a variant tRNA-i(met) with a G-to-T transversion in the highly conserved TCGA sequence in loop 4, a sequence position occupied exclusively by a purine (usually G) in almost 200 prokaryotic and eukaryotic tRNAs. One functional consequence of this base substitution is reduction in the rate of processing of the primary transcript of the gene. A second, demonstrated by microinjection into the germinal vesicle of the intact Xenopus laevis oocyte, is blockage of egress from the nucleus. It has been estimated that the human haploid genome contains 1,000 to 2,000 tRNA genes and that there are 50 to 60 chromatographically distinct tRNA species. These observations suggest redundancy of some tRNA genes. The studies of initiator methionine tRNA genes bear out this suspicion.[supplied by OMIM, Sep 2009]
TRX-CAT2-1 (TRNA-IMet (Anticodon CAT) 2-1) is an RNA Gene, and is affiliated with the tRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH06J027776 | Enhancer | 1.1 | FANTOM5 ENCODE | 600.7 | -0.2 | -242 | 1.7 | TEAD4 ZNF512 LEF1 IKZF1 JUND PRDM1 MTA2 ZNF24 MTA1 ZNF740 | TRX-CAT2-1 piR-30961-007 piR-33437-008 ZKSCAN8 ZSCAN12 ZKSCAN3 ZNF603P ZSCAN23 ZSCAN9 H4C10P |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000121433_9606 | tRNA | 72 | 4 |
HGNC: 12322, GtRNAdb: tRNA-iMet-CAT-2-1:CM000668.1:27745664-27745735, tRNA-iMet-CAT-2-1:CM000668.2:27777885-27777956, Rfam: RF00005, |
No disorders were found for TRX-CAT2-1 Gene.