Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal an... See more...
Aliases for TRPV4 Gene
Aliases for TRPV4 Gene
- Transient Receptor Potential Cation Channel Subfamily V Member 4 2 3 4 5
- OTRPC4 2 3 4
- TRP12 2 3 4
- VROAC 2 3 4
- Osmosensitive Transient Receptor Potential Channel 4 2 3
- Transient Receptor Potential Protein 12 3 4
- Vanilloid Receptor-Like Channel 2 3 4
- Osm-9-Like TRP Channel 4 3 4
- VR-OAC 2 4
- CMT2C 2 3
- VRL-2 2 4
- VRL2 3 4
- Transient Receptor Potential Cation Channel, Subfamily V, Member 4 2
- Vanilloid Receptor-Related Osmotically Activated Channel 3
- Vanilloid Receptor-Related Osmotically-Activated Channel 4
- OSM9-Like Transient Receptor Potential Channel 4 3
- Vanilloid Receptor-Like Protein 2 4
- HMSN2C 3
- SSQTL1 3
- BCYM3 3
- SPSMA 3
- TRPV4 5
- TrpV4 4
- SMAL 3
External Ids for TRPV4 Gene
- HGNC: 18083
- Entrez Gene: 59341
- Ensembl: ENSG00000111199
- OMIM: 605427
- UniProtKB: Q9HBA0
Previous GeneCards Identifiers for TRPV4 Gene
- GC12M109279
- GC12M110059
- GC12M108683
- GC12M110220
- GC12M107238
Summaries for TRPV4 Gene
-
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
GeneCards Summary for TRPV4 Gene
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a Protein Coding gene. Diseases associated with TRPV4 include Spondylometaphyseal Dysplasia, Kozlowski Type and Scapuloperoneal Spinal Muscular Atrophy. Among its related pathways are Cellular senescence (KEGG) and CREB Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and microtubule binding. An important paralog of this gene is TRPV1.
UniProtKB/Swiss-Prot Summary for TRPV4 Gene
-
Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501).
-
[Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli.
-
[Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
-
[Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
-
[Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
-
(Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X.
-
(Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X.
-
(Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X.
-
Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a member of the transient receptor potential (TRP) superfamily of ion channels, and have six members (TRPV1-6).
Additional gene information for TRPV4 Gene
- HGNC(18083)
- Entrez Gene(59341)
- Ensembl(ENSG00000111199)
- OMIM(605427)
- UniProtKB(Q9HBA0)
- Open Targets Platform(ENSG00000111199)
- Monarch Initiative
- Search for TRPV4 at DataMed
- Search for TRPV4 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRPV4 Gene
Genomics for TRPV4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRPV4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRPV4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRPV4
- Top Transcription factor binding sites by QIAGEN in the TRPV4 gene promoter:
-
- AP-4
- HSF2
- Nkx6-1
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- RP58
- Spz1
- TBP
- TFIID
Genomic Locations for TRPV4 Gene
Genomic Locations for TRPV4 Gene
- chr12:109,783,085-109,833,401
- (GRCh38/hg38)
- Size:
- 50,317 bases
- Orientation:
- Minus strand
- chr12:110,220,890-110,271,212
- (GRCh37/hg19)
- Size:
- 50,323 bases
- Orientation:
- Minus strand
Genomic View for TRPV4 Gene
Genes around TRPV4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.11 by HGNC
- 12q24.11 by Entrez Gene
- 12q24.11 by Ensembl
TRPV4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRPV4 Gene
Proteins for TRPV4 Gene
-
Protein details for TRPV4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HBA0-TRPV4_HUMAN
- Recommended name:
- Transient receptor potential cation channel subfamily V member 4
- Protein Accession:
- Q9HBA0
- B7ZKQ6
- Q17R79
- Q2Y122
- Q2Y123
- Q2Y124
- Q86YZ6
- Q8NDY7
- Q8NG64
- Q96Q92
- Q96RS7
- Q9HBC0
Protein attributes for TRPV4 Gene
- Size:
- 871 amino acids
- Molecular mass:
- 98281 Da
- Quaternary structure:
-
- Homotetramer (Probable). Self-associates in an isoform-specific manner (PubMed:16293632). Isoform 1 and isoform 5 can oligomerize, but isoform 2, isoform 4 and isoform 6 cannot oligomerize (PubMed:16293632). Interacts with calmodulin (PubMed:12724311). Interacts with Map7 and Src family Tyr protein kinases LYN, SRC, FYN, HCK, LCK and YES (By similarity). Interacts with CTNNB1 (By similarity). The TRPV4 and CTNNB1 complex can interact with CDH1 (By similarity). Interacts with PACSIN1, PACSIN2 and PACSIN3 (via SH3 domain) (By similarity). Part of a complex containing MLC1, AQP4, HEPACAM and ATP1B1 (PubMed:22328087). Interacts with ITPR3 (PubMed:18826956). Interacts with AQP5; the interaction is probably indirect and regulates TRPV4 activation by hypotonicity (By similarity). Interacts with ANO1 (By similarity). Interacts (via C-terminus) with PKD2 (via C-terminus) (PubMed:18695040). Interacts with DDX3X; this interaction is decreased when the channel is activated (PubMed:29899501).
- Miscellaneous:
-
- [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
- [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
- [Isoform 5]: Forms active ion channels.
- [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
Protein Expression for TRPV4 Gene
Post-translational modifications for TRPV4 Gene
- N-glycosylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TRPV4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ TRPV4 Antibody
- Novus Biologicals Antibodies for TRPV4
-
Abcam antibodies for TRPV4
- Invitrogen Antibodies for TRPV4 (AFLGC-Trpv4)
- antibodies-online: Show 46 available TRPV4 Antibodies ranked by validation data
- Compare Top TRPV4 Antibodies
-
Recommended
- 80 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 45 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 43 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for TRPV4
Protein Products
-
OriGene Purified Proteins for TRPV4
- Search Origene for MassSpec and Protein Over-expression Lysates for TRPV4
- Origene Custom Protein Services for TRPV4
- Novus Biologicals lysates for TRPV4
-
Signalway Proteins for TRPV4
-
Abcam proteins for TRPV4
Assay Products
- antibodies-online: Show 3 available TRPV4 Elisa Kits ranked by validation data
- Compare Top TRPV4 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TRPV4 Gene
Domains & Families for TRPV4 Gene
Gene Families for TRPV4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Potential drug targets
- Predicted membrane proteins
- Voltage-gated ion channels
Protein Domains for TRPV4 Gene
- InterPro:
- Blocks:
-
- Ankyrin repeat signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TRPV4 Gene
- GenScript: Design optimal peptide antigens:
-
- Vanilloid receptor-related osmotically-activated channel (TRPV4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9HBA0UniProtKB/Swiss-Prot:
TRPV4_HUMAN :- The ANK repeat region mediates interaction with Ca(2+)-calmodulin and ATP binding (By similarity). The ANK repeat region mediates interaction with phosphatidylinositol-4,5-bisphosphate and related phosphatidylinositides (PubMed:25256292).
- Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily.
- Domain:
-
- The ANK repeat region mediates interaction with Ca(2+)-calmodulin and ATP binding (By similarity). The ANK repeat region mediates interaction with phosphatidylinositol-4,5-bisphosphate and related phosphatidylinositides (PubMed:25256292).
- Family:
-
- Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily.
Function for TRPV4 Gene
Molecular function for TRPV4 Gene
- UniProtKB/Swiss-Prot Function:
- Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501).
- UniProtKB/Swiss-Prot Function:
- [Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli.
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
- UniProtKB/Swiss-Prot Function:
- [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
- UniProtKB/Swiss-Prot Function:
- [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Facilitates hepatitis C virus (HCV) replication, possibly through its action on DDX3X.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Facilitates Dengue virus (DENV) replication, possibly through its action on DDX3X.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Facilitates Zika virus (ZIKV) replication, possibly through its action on DDX3X.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Channel activation is inhibited by binding to phosphatidylinositol-4,5-bisphosphate, and to a much lesser degree by phosphatidylinositol-3,4,5-trisphosphate. Not inhibited by phosphatidylinositol-3,4-bisphosphate and phosphatidylinositol-3,5-bisphosphate.
Phenotypes From GWAS Catalog for TRPV4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003779 | actin binding | ISS | -- |
| GO:0005034 | osmosensor activity | IEA | -- |
| GO:0005080 | protein kinase C binding | ISS | -- |
| GO:0005216 | ion channel activity | IBA | 21873635 |
Phenotypes for TRPV4 Gene
- MGI mutant phenotypes for TRPV4:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for TRPV4:
Animal Models for TRPV4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for TRPV4
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRPV4 - Select products 50% OFF >
- * TRPV4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRPV4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRPV4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRPV4
miRNA for TRPV4 Gene
- miRTarBase miRNAs that target TRPV4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRPV4
- Browse OriGene Inhibitory RNA Products For TRPV4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPV4
Clone Products
- Applied Biological Materials (abm): Clones for TRPV4 - Select products 50% OFF >
- * TRPV4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226813
- MR226813
- MR226813L1
- MR226813L2
- MR226813L3
- MR226813L4
- RC220097
- RC220097L3
- RC220097L4
- RC220160
- RC220160L1
- RC220160L2
- RC220160L3
- RC220160L4
- RC230483
- RC230483L3
- RC230483L4
- RC230519
- RC230519L3
- RC230519L4
- RC230525
- RC230525L3
- RC230525L4
- RG220097
- RG220160
- RG230483
- RG230519
- RG230525
- RR214986
- RR214986L3
- RR214986L4
- MR226813L1V
- MR226813L2V
- MR226813L3V
- MR226813L4V
- RC220097L3V
- RC220097L4V
- RC220160L1V
- RC220160L2V
- RC220160L3V
- RC220160L4V
- RC230483L3V
- RC230483L4V
- RC230519L3V
- RC230519L4V
- RC230525L3V
- RC230525L4V
- RR214986L3V
- RR214986L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRPV4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRPV4
Cell Line Products
-
Horizon Cell Lines for TRPV4
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TRPV4 Gene
Localization for TRPV4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRPV4 Gene
- Cell membrane. Apical cell membrane. Multi-pass membrane protein. Cell junction, adherens junction. Cell projection, cilium. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. {ECO:0000269 PubMed:16293632, ECO:0000269 PubMed:20037587, ECO:0000269 PubMed:20037588}.
- [Isoform 1]: Cell membrane.
- [Isoform 5]: Cell membrane.
- [Isoform 2]: Endoplasmic reticulum.
- [Isoform 4]: Endoplasmic reticulum.
- [Isoform 6]: Endoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 4 |
| endoplasmic reticulum | 4 |
| extracellular | 3 |
| nucleus | 3 |
| mitochondrion | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005881 | colocalizes_with cytoplasmic microtubule | ISS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRPV4 Gene
Pathways & Interactions for TRPV4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Ion channel transport | ||
| 2 | Cellular senescence (KEGG) | ||
| 3 | Fluid shear stress and atherosclerosis | ||
| 4 | Development Endothelin-1/EDNRA signaling | ||
| 5 | CREB Pathway |
Intracellular Calcium Signaling
.50
|
|
Pathways by source for TRPV4 Gene
4 Reactome pathways for TRPV4 Gene
3 KEGG pathways for TRPV4 Gene
1 Qiagen pathway for TRPV4 Gene
- Intracellular Calcium Signaling
Interacting Proteins for TRPV4 Gene
Selected Interacting proteins:
Q9HBA0-TRPV4_HUMAN
ENSP00000406191
for TRPV4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TRPV4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0002024 | diet induced thermogenesis | IEA | -- |
| GO:0006811 | ion transport | IEA | -- |
| GO:0006816 | calcium ion transport | NAS | 11025659 |
| GO:0006874 | cellular calcium ion homeostasis | IDA | 12724311 |
Drugs & Compounds for TRPV4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Butamben | Approved, Withdrawn | Pharma | Target, inhibitor | 0 | ||
| cannabidiol | Approved, Investigational | Pharma | Agonist, Partial agonist, Antagonist, Channel blocker, Activator, Target, activator | 0 | ||
| Medical Cannabis | Experimental, Investigational | Pharma | Target | 0 | ||
| Resiniferatoxin | Investigational | Pharma | Pore Blocker, Activator, Agonist | Potent vanilloid receptor agonist | 0 | |
| Nabiximols | Investigational | Pharma | Target | 59 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4α-PDH |
|
Activator |
|
|
||
| bisandrographolide |
|
Activator |
|
|
||
| (E)-Capsaicin |
|
404-86-4 |
|
|
(5) Tocris Compounds for TRPV4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| (E)-Capsaicin | Prototypic vanilloid receptor agonist | 404-86-4 |
| Capsazepine | Vanilloid receptor antagonist; also activator of ENaCdelta | 138977-28-3 |
| Olvanil | Potent vanilloid receptor agonist | 58493-49-5 |
| Resiniferatoxin | Potent vanilloid receptor agonist | 57444-62-9 |
| STEARDA | Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors | 105955-10-0 |
(3) ApexBio Compounds for TRPV4 Gene
Transcripts for TRPV4 Gene
mRNA/cDNA for TRPV4 Gene
- 5 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000261740 3228 nts (view in UCSC)
- ENST00000418703 3247 nts (view in UCSC)
- ENST00000536570 545 nts (view in UCSC)
- ENST00000536838 2514 nts (view in UCSC)
- ENST00000537083 2436 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRPV4 - Select products 50% OFF >
- * TRPV4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRPV4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRPV4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRPV4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRPV4
- Browse OriGene Inhibitory RNA Products For TRPV4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPV4
Clone Products
- Applied Biological Materials (abm): Clones for TRPV4 - Select products 50% OFF >
- * TRPV4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226813
- MR226813
- MR226813L1
- MR226813L2
- MR226813L3
- MR226813L4
- RC220097
- RC220097L3
- RC220097L4
- RC220160
- RC220160L1
- RC220160L2
- RC220160L3
- RC220160L4
- RC230483
- RC230483L3
- RC230483L4
- RC230519
- RC230519L3
- RC230519L4
- RC230525
- RC230525L3
- RC230525L4
- RG220097
- RG220160
- RG230483
- RG230519
- RG230525
- RR214986
- RR214986L3
- RR214986L4
- MR226813L1V
- MR226813L2V
- MR226813L3V
- MR226813L4V
- RC220097L3V
- RC220097L4V
- RC220160L1V
- RC220160L2V
- RC220160L3V
- RC220160L4V
- RC230483L3V
- RC230483L4V
- RC230519L3V
- RC230519L4V
- RC230525L3V
- RC230525L4V
- RR214986L3V
- RR214986L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TRPV4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRPV4
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - |
Relevant External Links for TRPV4 Gene
- GeneLoc Exon Structure for
- TRPV4
Expression for TRPV4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Mesenchymal Condensate Cells Zeugopod
- Zeugopod Growth Plate
- HyStem+BMP4-induced 4D20.8 cells
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Mesenchymal Condensate Cells Zeugopod
- Meckel's Cartilage
- HyStem+BMP4-induced 4D20.8 cells
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Adult Endothelial Cells Blood Brain Barrier
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for TRPV4 Gene
This gene is overexpressed in Minor Salivary Gland (x8.1), Kidney - Cortex (x7.0), and Esophagus - Mucosa (x5.1).
This gene is overexpressed in Placenta (66.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRPV4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRPV4
SOURCE GeneReport for Unigene cluster for TRPV4 Gene:
Hs.506713mRNA Expression by UniProt/SwissProt for TRPV4 Gene:
Q9HBA0-TRPV4_HUMAN
Tissue specificity:
Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).
Evidence on tissue expression from TISSUES for TRPV4 Gene
- Kidney(4.6)
- Intestine(4.5)
- Nervous system(3)
- Muscle(2.8)
- Heart(2.8)
- Skin(2.6)
- Lung(2.4)
- Pancreas(2.4)
- Blood(2.4)
- Adrenal gland(2.2)
- Liver(2.2)
- Bone(2.1)
- Eye(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPV4 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cranial nerve
- epiglottis
- eye
- face
- forehead
- head
- jaw
- larynx
- mandible
- maxilla
- mouth
- neck
- nose
- pharynx
- skull
- vocal cord
Thorax:
- bronchus
- chest wall
- clavicle
- diaphragm
- lung
- rib
- rib cage
- scapula
- sternum
- trachea
Pelvis:
- pelvis
- prostate
- urethra
- urinary bladder
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- peripheral nerve
- peripheral nervous system
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for TRPV4
-
OriGene qPCR primer pairs and template standards for TRPV4
Gene Expression Assay Products
Orthologs for TRPV4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRPV4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TRPV4 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | TRPV4 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Trpv4 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Trpv4 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TRPV4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TRPV4 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | trpv4 30 |
|
||
| Str.16318 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | trpv4 30 31 |
|
OneToOne | |
| wufp52e02 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | nan 31 |
|
ManyToMany | |
| iav 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | ocr-4 31 |
|
ManyToMany | |
| ocr-3 31 |
|
ManyToMany | |||
| ocr-1 31 |
|
ManyToMany | |||
| osm-9 31 32 |
|
ManyToMany | |||
| ocr-2 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for TRPV4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TRPV4 Gene
- ENSEMBL:
- Gene Tree for TRPV4 (if available)
- TreeFam:
- Gene Tree for TRPV4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRPV4: view image
Paralogs for TRPV4 Gene
Variants for TRPV4 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TRPV4 Gene
- TRPV4_HUMAN-Q9HBA0
- Genetic variations in TRPV4 determine the sodium serum level quantitative trait locus 1 (SSQTL1) [MIM:613508]. In some populations, variant Pro19Ser has been shown to be significantly associated with hyponatremia defined as serum sodium concentration below or equal to 135 mEq/L.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRPV4 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 637419 | Uncertain Significance: Charcot-Marie-Tooth disease | 109,803,009(-) | G/T | MISSENSE_VARIANT | |
| 637420 | Uncertain Significance: Charcot-Marie-Tooth disease | 109,798,862(-) | T/A | MISSENSE_VARIANT | |
| 637421 | Uncertain Significance: Charcot-Marie-Tooth disease | 109,788,506(-) | G/A | MISSENSE_VARIANT | |
| 639307 | Uncertain Significance: Charcot-Marie-Tooth disease axonal type 2C; Charcot-Marie-Tooth disease | 109,814,747(-) | T/C | MISSENSE_VARIANT | |
| 639405 | Uncertain Significance: Charcot-Marie-Tooth disease axonal type 2C | 109,798,889(-) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1110896 | OTHER | inversion | 24896259 |
Residual Variation Intolerance Score:
12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.37;
76.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRPV4 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for TRPV4 Gene
(66) MalaCards diseases for TRPV4 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| spondylometaphyseal dysplasia, kozlowski type |
|
|
| scapuloperoneal spinal muscular atrophy |
|
|
| hereditary motor and sensory neuropathy, type iic |
|
|
| parastremmatic dwarfism |
|
|
| digital arthropathy-brachydactyly, familial |
|
Search TRPV4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TRPV4_HUMAN- Brachyolmia 3 (BCYM3) [MIM:113500]: A form of brachyolmia, a clinically and genetically heterogeneous skeletal dysplasia primarily affecting the spine and characterized by a short trunk, short stature, and platyspondyly. BCYM3 is an autosomal dominant form with severe scoliosis with or without kyphosis, and flattened irregular cervical vertebrae. {ECO:0000269 PubMed:18587396}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Spondylometaphyseal dysplasia Kozlowski type (SMDK) [MIM:184252]: A form of spondylometaphyseal dysplasia, a group of short stature disorders distinguished by abnormalities in the vertebrae and the metaphyses of the tubular bones. It is characterized by postnatal dwarfism, significant scoliosis and mild metaphyseal abnormalities in the pelvis. The vertebrae exhibit platyspondyly and overfaced pedicles. {ECO:0000269 PubMed:19232556, ECO:0000269 PubMed:20577006, ECO:0000269 PubMed:22702953}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Metatropic dysplasia (MTD) [MIM:156530]: A severe spondyloepimetaphyseal dysplasia characterized by short limbs with limitation and enlargement of joints and usually severe kyphoscoliosis. Radiologic features include severe platyspondyly, severe metaphyseal enlargement and shortening of long bones. {ECO:0000269 PubMed:19232556, ECO:0000269 PubMed:20425821, ECO:0000269 PubMed:20577006, ECO:0000269 PubMed:22702953, ECO:0000269 PubMed:26249260, ECO:0000269 Ref.6}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Neuronopathy, distal hereditary motor, 8 (HMN8) [MIM:600175]: A clinically variable, neuromuscular disorder characterized by congenital lower motor neuron disorder restricted to the lower part of the body. Clinical manifestations include non-progressive muscular atrophy, thigh muscle atrophy, weak thigh adductors, weak knee and foot extensors, minimal jaw muscle and neck flexor weakness, flexion contractures of knees and pes equinovarus. Tendon reflexes are normal. {ECO:0000269 PubMed:20037588, ECO:0000269 PubMed:22526352, ECO:0000269 PubMed:22702953}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Charcot-Marie-Tooth disease 2C (CMT2C) [MIM:606071]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. {ECO:0000269 PubMed:20037586, ECO:0000269 PubMed:20037587, ECO:0000269 PubMed:20037588, ECO:0000269 PubMed:21115951, ECO:0000269 PubMed:21288981, ECO:0000269 PubMed:22702953, ECO:0000269 PubMed:25256292}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Scapuloperoneal spinal muscular atrophy (SPSMA) [MIM:181405]: A clinically variable neuromuscular disorder characterized by neurogenic scapuloperoneal amyotrophy, laryngeal palsy, congenital absence of muscles, progressive scapuloperoneal atrophy and progressive distal weakness and amyotrophy. {ECO:0000269 PubMed:20037587, ECO:0000269 PubMed:22702953}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Spondyloepiphyseal dysplasia Maroteaux type (SEDM) [MIM:184095]: A clinically variable spondyloepiphyseal dysplasia with manifestations limited to the musculoskeletal system. Clinical features include short stature, brachydactyly, platyspondyly, short and stubby hands and feet, epiphyseal hypoplasia of the large joints, and iliac hypoplasia. Intelligence is normal. {ECO:0000269 PubMed:20503319, ECO:0000269 PubMed:22702953}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Parastremmatic dwarfism (PSTD) [MIM:168400]: A bone dysplasia characterized by severe dwarfism, kyphoscoliosis, distortion and bowing of the extremities, and contractures of the large joints. Radiographically, the disease is characterized by a combination of decreased bone density, bowing of the long bones, platyspondyly and striking irregularities of endochondral ossification with areas of calcific stippling and streaking in radiolucent epiphyses, metaphyses and apophyses. {ECO:0000269 PubMed:20503319}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Digital arthropathy-brachydactyly, familial (FDAB) [MIM:606835]: A disorder characterized by irregularities in the proximal articular surfaces of the distal interphalangeal joints of the hand. Individuals appear normal at birth, with no clinical or radiographic evidence of a developmental skeletal dysplasia. The earliest changes appear during the first decade of life. By adulthood, all interphalangeal, metacarpophalangeal, and metatarsophalangeal joints are affected by a deforming, painful osteoarthritis. The remainder of the skeleton is clinically and radiographically unaffected. {ECO:0000269 PubMed:21964574}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Avascular necrosis of the femoral head, primary 2 (ANFH2) [MIM:617383]: A disease characterized by mechanical failure of the subchondral bone, and degeneration of the hip joint. It usually leads to destruction of the hip joint in the third to fifth decade of life. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy in leg length, cause considerable disability. {ECO:0000269 PubMed:27330106}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TRPV4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for TRPV4 Gene
Publications for TRPV4 Gene
- Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. (PMID: 20037587) Deng HX … Siddique T (Nature genetics 2010) 2 3 4 23
- A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia. (PMID: 19666518) Tian W … Cohen DM (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 23 41
- OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. (PMID: 11025659) Strotmann R … Plant TD (Nature cell biology 2000) 2 3 4 23
- Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. (PMID: 11081638) Liedtke W … Heller S (Cell 2000) 2 3 4 23
- Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia. (PMID: 20425821) Camacho N … Cohn DH (American journal of medical genetics. Part A 2010) 3 4 23
ExternalLinks
Products for TRPV4 Gene
- Custom Antibody ServicesOriGene Antibodies for TRPV4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TRPV4
- Search Origene for MassSpec and Protein Over-expression Lysates for TRPV4
- Origene Custom Protein Services for TRPV4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRPV4
- Browse OriGene Inhibitory RNA Products For TRPV4
- OriGene qPCR primer pairs for TRPV4
- OriGene qPCR primer pairs and template standards for TRPV4
- OriGene CRISPR knockouts for TRPV4
- MG226813
- MR226813
- MR226813L1
- MR226813L2
- MR226813L3
- MR226813L4
- RC220097
- RC220097L3
- RC220097L4
- RC220160
- RC220160L1
- RC220160L2
- RC220160L3
- RC220160L4
- RC230483
- RC230483L3
- RC230483L4
- RC230519
- RC230519L3
- RC230519L4
- RC230525
- RC230525L3
- RC230525L4
- RG220097
- RG220160
- RG230483
- RG230519
- RG230525
- RR214986
- RR214986L3
- RR214986L4
- MR226813L1V
- MR226813L2V
- MR226813L3V
- MR226813L4V
- RC220097L3V
- RC220097L4V
- RC220160L1V
- RC220160L2V
- RC220160L3V
- RC220160L4V
- RC230483L3V
- RC230483L4V
- RC230519L3V
- RC230519L4V
- RC230525L3V
- RC230525L4V
- RR214986L3V
- RR214986L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TRPV4
- Sino Biological Human cDNA Clone for TRPV4
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TRPV4
- Novus Biologicals lysates for TRPV4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TRPV4
- Abcam proteins for TRPV4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for TRPV4
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for TRPV4 (AFLGC-Trpv4)
- ApexBio compounds for TRPV4
- VectorBuilder Custom and pre-made DNA vectors for TRPV4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TRPV4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TRPV4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TRPV4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TRPV4
- antibodies-online: Show 46 available TRPV4 Antibodies ranked by validation data
- Compare Top TRPV4 Antibodies
- Recommended
- 80 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 45 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 43 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- antibodies-online: Show 3 available TRPV4 Elisa Kits ranked by validation data
- Compare Top TRPV4 Elisa Kits
- Quality Products:
- antibodies-online: Show 6 available TRPV4 Proteins ranked by validation data
- Compare Top TRPV4 Proteins
- Horizon Cell Lines for TRPV4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRPV4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRPV4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TRPV4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPV4
- Signalway Proteins for TRPV4
Sources for TRPV4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB