Aliases for TRPV2 Gene
External Ids for TRPV2 Gene
Previous GeneCards Identifiers for TRPV2 Gene
This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRPV2 Gene
TRPV2 (Transient Receptor Potential Cation Channel Subfamily V Member 2) is a Protein Coding gene. Diseases associated with TRPV2 include Facial Dermatosis and Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques. Among its related pathways are Ion channel transport and TRP channels. Gene Ontology (GO) annotations related to this gene include ion channel activity and cation channel activity. An important paralog of this gene is TRPV1.
UniProtKB/Swiss-Prot Summary for TRPV2 Gene
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a member of the transient receptor potential (TRP) superfamily of ion channels, and have six members (TRPV1-6).