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Aliases for TRPV2 Gene

Aliases for TRPV2 Gene

  • Transient Receptor Potential Cation Channel Subfamily V Member 2 2 3 5
  • Vanilloid Receptor-Like Protein 1 3 4
  • Osm-9-Like TRP Channel 2 3 4
  • OTRPC2 3 4
  • VRL-1 3 4
  • VRL 3 4
  • Transient Receptor Potential Cation Channel, Subfamily V, Member 2 2
  • TrpV2 4
  • VRL1 3

External Ids for TRPV2 Gene

Previous GeneCards Identifiers for TRPV2 Gene

  • GC17P016680
  • GC17P017429
  • GC17P016261
  • GC17P016519
  • GC17P016259
  • GC17P016318
  • GC17P016186

Summaries for TRPV2 Gene

Entrez Gene Summary for TRPV2 Gene

  • This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRPV2 Gene

TRPV2 (Transient Receptor Potential Cation Channel Subfamily V Member 2) is a Protein Coding gene. Diseases associated with TRPV2 include Retina Lymphoma and Dentin Sensitivity. Among its related pathways are Toll-like receptor signaling pathway and CREB Pathway. Gene Ontology (GO) annotations related to this gene include ion channel activity and cation channel activity. An important paralog of this gene is TRPV1.

UniProtKB/Swiss-Prot for TRPV2 Gene

  • Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

Tocris Summary for TRPV2 Gene

  • Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a member of the transient receptor potential (TRP) superfamily of ion channels, and have six members (TRPV1-6).

Gene Wiki entry for TRPV2 Gene

Additional gene information for TRPV2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPV2 Gene

Genomics for TRPV2 Gene

GeneHancer (GH) Regulatory Elements for TRPV2 Gene

Promoters and enhancers for TRPV2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I016414 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 578.2 +2.4 2447 6.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B IRF4 POLR2B ZNF766 ZNF207 TRPV2 ENSG00000264739 ZSWIM7 NCOR1 FLCN ADORA2B CENPV PIGL CDRT1 ENSG00000239203
GH17I016377 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 8.8 -35.4 -35441 4.6 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC PPARGC1A UBB ENSG00000266538 PPIAP53 PIGL NCOR1 TVP23C LOC644422 LRRC75A-AS1 FLCN ACTG1P24
GH17I016406 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -7.8 -7831 2.2 HDGF SMAD1 ZFP64 SIN3A FEZF1 YBX1 IRF4 ZNF213 ZNF207 ZNF548 PIGL PPIAP53 ENSG00000266538 NCOR1 TVP23C MPRIP-AS1 ZNF286A LOC644422 UPF3AP1 MPRIP
GH17I016385 Enhancer 1.4 Ensembl ENCODE dbSUPER 8.9 -28.7 -28668 2.7 FOXA2 ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF213 ZNF143 ZNF548 SP3 GC17M016375 PIGL ENSG00000266538 LOC644422 TVP23C PPIAP53 NCOR1 RPL13P12 ACTG1P24 TBC1D26
GH17I016397 Enhancer 1.1 Ensembl ENCODE 10 -16.9 -16937 1.8 ATF1 FOXA2 ARNT YY1 NCOA2 TCF12 FOS ATF7 RXRA NCOA1 CENPV LRRC75A-AS1 LRRC75A TRPV2 TNFRSF13B GC17P016393
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRPV2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRPV2 gene promoter:

Genomic Locations for TRPV2 Gene

Genomic Locations for TRPV2 Gene
chr17:16,415,542-16,437,003
(GRCh38/hg38)
Size:
21,462 bases
Orientation:
Plus strand
chr17:16,318,856-16,340,317
(GRCh37/hg19)

Genomic View for TRPV2 Gene

Genes around TRPV2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPV2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPV2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPV2 Gene

Proteins for TRPV2 Gene

  • Protein details for TRPV2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5S1-TRPV2_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily V member 2
    Protein Accession:
    Q9Y5S1
    Secondary Accessions:
    • A6NML2
    • A8K0Z0
    • Q9Y670

    Protein attributes for TRPV2 Gene

    Size:
    764 amino acids
    Molecular mass:
    85981 Da
    Quaternary structure:
    • Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).

    Three dimensional structures from OCA and Proteopedia for TRPV2 Gene

neXtProt entry for TRPV2 Gene

Post-translational modifications for TRPV2 Gene

No data available for DME Specific Peptides for TRPV2 Gene

Domains & Families for TRPV2 Gene

Gene Families for TRPV2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for TRPV2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5S1

UniProtKB/Swiss-Prot:

TRPV2_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
genes like me logo Genes that share domains with TRPV2: view

Function for TRPV2 Gene

Molecular function for TRPV2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.

Gene Ontology (GO) - Molecular Function for TRPV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity TAS 10201375
GO:0005261 cation channel activity IEA,IDA 10201375
GO:0005262 calcium channel activity TAS,IBA --
GO:0015075 ion transmembrane transporter activity TAS 10201375
genes like me logo Genes that share ontologies with TRPV2: view
genes like me logo Genes that share phenotypes with TRPV2: view

Animal Models for TRPV2 Gene

MGI Knock Outs for TRPV2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPV2

miRNA for TRPV2 Gene

miRTarBase miRNAs that target TRPV2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPV2 Gene

Localization for TRPV2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPV2 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPV2 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRPV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS,IEA --
GO:0005887 integral component of plasma membrane TAS 10201375
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with TRPV2: view

Pathways & Interactions for TRPV2 Gene

genes like me logo Genes that share pathways with TRPV2: view

Gene Ontology (GO) - Biological Process for TRPV2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10201375
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0007600 sensory perception TAS 10201375
GO:0009266 response to temperature stimulus IDA 10201375
genes like me logo Genes that share ontologies with TRPV2: view

No data available for SIGNOR curated interactions for TRPV2 Gene

Drugs & Compounds for TRPV2 Gene

(16) Drugs for TRPV2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cannabidiol Approved, Investigational Pharma Partial agonist, Agonist, Target 0
Amiloride Approved Pharma Channel blocker, blocker 55
Probenecid Approved, Investigational Pharma Inhibition, Inhibitor 35
calcium Approved Nutra 0
cyclic amp Experimental Pharma 0

(2) Additional Compounds for TRPV2 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
(E)-Capsaicin
404-86-4

(5) Tocris Compounds for TRPV2 Gene

Compound Action Cas Number
(E)-Capsaicin Prototypic vanilloid receptor agonist 404-86-4
Capsazepine Vanilloid receptor antagonist; also activator of ENaCdelta 138977-28-3
Olvanil Potent vanilloid receptor agonist 58493-49-5
Resiniferatoxin Potent vanilloid receptor agonist 57444-62-9
STEARDA Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors 105955-10-0

(2) ApexBio Compounds for TRPV2 Gene

Compound Action Cas Number
HC-030031 TRPA1 channel blocker,potent and selective 349085-38-7
Probenecid 57-66-9
genes like me logo Genes that share compounds with TRPV2: view

Drug Products

Transcripts for TRPV2 Gene

mRNA/cDNA for TRPV2 Gene

(12) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRPV2 Gene

Transient receptor potential cation channel, subfamily V, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPV2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: -
SP2:
SP3: - -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:
SP9: -

Relevant External Links for TRPV2 Gene

GeneLoc Exon Structure for
TRPV2
ECgene alternative splicing isoforms for
TRPV2

Expression for TRPV2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRPV2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPV2 Gene

This gene is overexpressed in Whole Blood (x6.8).

Protein differential expression in normal tissues from HIPED for TRPV2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.6), Adrenal (10.9), CD8 Tcells (8.6), Pancreas (7.8), and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRPV2 Gene



Protein tissue co-expression partners for TRPV2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRPV2 Gene:

TRPV2

SOURCE GeneReport for Unigene cluster for TRPV2 Gene:

Hs.279746

Evidence on tissue expression from TISSUES for TRPV2 Gene

  • Skin(4.7)
  • Nervous system(4.6)
  • Blood(4.3)
  • Liver(4.1)
  • Lung(2.9)
  • Kidney(2.6)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with TRPV2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPV2 Gene

Orthologs for TRPV2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPV2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPV2 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia TRPV2 33 34
  • 85.41 (n)
cow
(Bos Taurus)
Mammalia TRPV2 33 34
  • 82.31 (n)
mouse
(Mus musculus)
Mammalia Trpv2 33 16 34
  • 82.05 (n)
rat
(Rattus norvegicus)
Mammalia Trpv2 33
  • 80.52 (n)
oppossum
(Monodelphis domestica)
Mammalia TRPV2 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRPV2 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRPV2 33 34
  • 61.82 (n)
lizard
(Anolis carolinensis)
Reptilia TRPV2 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trpv1 33
  • 59.14 (n)
zebrafish
(Danio rerio)
Actinopterygii trpv1 34
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta nan 34
  • 20 (a)
ManyToMany
iav 34
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ocr-4 34
  • 21 (a)
ManyToMany
ocr-3 34
  • 19 (a)
ManyToMany
ocr-1 34
  • 18 (a)
ManyToMany
ocr-2 34
  • 17 (a)
ManyToMany
osm-9 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
Species where no ortholog for TRPV2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPV2 Gene

ENSEMBL:
Gene Tree for TRPV2 (if available)
TreeFam:
Gene Tree for TRPV2 (if available)

Paralogs for TRPV2 Gene

Paralogs for TRPV2 Gene

(5) SIMAP similar genes for TRPV2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRPV2: view

Variants for TRPV2 Gene

Sequence variations from dbSNP and Humsavar for TRPV2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000007923 -- 16,437,056(+) A/G downstream_transcript_variant
rs1000081388 -- 16,425,023(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000117071 -- 16,418,944(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000282934 -- 16,430,404(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000547162 -- 16,429,431(+) T/C 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRPV2 Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV deletion 23290073
esv3449108 CNV insertion 20981092
nsv1063764 CNV loss 25217958
nsv953835 CNV deletion 24416366

Variation tolerance for TRPV2 Gene

Residual Variation Intolerance Score: 9.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPV2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPV2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPV2 Gene

Disorders for TRPV2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRPV2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retina lymphoma
  • lymphoma of retina
dentin sensitivity
  • sensitive dentin
- elite association - COSMIC cancer census association via MalaCards
Search TRPV2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRPV2

genes like me logo Genes that share disorders with TRPV2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPV2 Gene

Publications for TRPV2 Gene

  1. A capsaicin-receptor homologue with a high threshold for noxious heat. (PMID: 10201375) Caterina MJ … Julius D (Nature 1999) 2 3 4 22 58
  2. Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma. (PMID: 20113837) Liu G … Miao X (Cancer genetics and cytogenetics 2010) 3 22 58
  3. Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain. (PMID: 19482060) Axelsson HE … Zygmunt PM (Neuroscience 2009) 3 22 58
  4. Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death. (PMID: 19619644) Saunders CI … Geraghty DP (Biochimica et biophysica acta 2009) 3 22 58
  5. Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage. (PMID: 17977643) Caprodossi S … Santoni G (European urology 2008) 3 22 58

Products for TRPV2 Gene

Sources for TRPV2 Gene

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