Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion ... See more...

Aliases for TRPV1 Gene

Aliases for TRPV1 Gene

  • Transient Receptor Potential Cation Channel Subfamily V Member 1 2 3 4 5
  • Vanilloid Receptor Subtype 1 2 3
  • Osm-9-Like TRP Channel 1 3 4
  • Capsaicin Receptor 3 4
  • OTRPC1 3 4
  • VR1 3 4
  • Transient Receptor Potential Cation Channel, Subfamily V, Member 1 2
  • Transient Receptor Potential Vanilloid 1a 3
  • Transient Receptor Potential Vanilloid 1b 3
  • Vanilloid Receptor 1 4
  • TrpV1 4

External Ids for TRPV1 Gene

Previous HGNC Symbols for TRPV1 Gene

  • VR1

Previous GeneCards Identifiers for TRPV1 Gene

  • GC17M003782
  • GC17M003419
  • GC17M003675
  • GC17M003415
  • GC17M003360
  • GC17M003469
  • GC17M003471

Summaries for TRPV1 Gene

Entrez Gene Summary for TRPV1 Gene

  • Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRPV1 Gene

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a Protein Coding gene. Diseases associated with TRPV1 include Somatoform Disorder and Burning Mouth Syndrome. Among its related pathways are Ion channel transport and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and ion channel activity. An important paralog of this gene is TRPV4.

UniProtKB/Swiss-Prot Summary for TRPV1 Gene

  • Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

Tocris Summary for TRPV1 Gene

  • Vanilloids are a group of compounds, structurally related to capsaicin, thought to exert their actions via vanilloid receptors. The vanilloid receptor family (TRPV) is a member of the transient receptor potential (TRP) superfamily of ion channels, and have six members (TRPV1-6).

Gene Wiki entry for TRPV1 Gene

Additional gene information for TRPV1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRPV1 Gene

Genomics for TRPV1 Gene

GeneHancer (GH) Regulatory Elements for TRPV1 Gene

Promoters and enhancers for TRPV1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J003597 Promoter 0.4 EPDnew 500.4 +12.3 12316 0.1 SMARCA4 TRPV1 5MWI_A-071 ENSG00000261916 ENSG00000262304
GH17J003593 Promoter 0.3 EPDnew 500.4 +16.2 16221 0.1 5MWI_A-071 RF00017-2233 TRPV1 piR-50717 ENSG00000262304
GH17J003562 Enhancer 0.9 Ensembl ENCODE 12 +46.3 46333 1.2 ZBTB40 SIN3A SP1 ZBTB11 TRIM22 TCF12 ZNF263 MEF2B NBN ZFHX2 MG828730-028 piR-33492-016 piR-31432-265 piR-44277-002 piR-36393-214 piR-31162-189 piR-50308-258 piR-53431-269 piR-50417-018 piR-46662-264
GH17J003594 Enhancer 0.7 Ensembl ENCODE 8.2 +14.6 14610 2.4 JUND FOS ZIC2 ZBTB17 ZNF335 SCRT1 PRDM10 GLIS1 ZFP69B MAZ 5MWI_A-071 RF00017-2233 TRPV1 SHPK TRPV3 ENSG00000261916 ENSG00000262304
GH17J003528 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.2 +79.2 79210 4.4 TEAD4 KDM6A RFX1 TEAD1 RBM25 TFDP1 SAP130 YY1 ZNF205 SMAD4 lnc-SPATA22-1 TRPV3 ASPA OR1E2 CAMKK1 TRPV1 RF00017-2232 MG828730-028
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRPV1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRPV1

Top Transcription factor binding sites by QIAGEN in the TRPV1 gene promoter:
  • Sp1

Genomic Locations for TRPV1 Gene

Genomic Locations for TRPV1 Gene
chr17:3,565,444-3,609,411
(GRCh38/hg38)
Size:
43,968 bases
Orientation:
Minus strand
chr17:3,468,738-3,512,705
(GRCh37/hg19)
Size:
43,968 bases
Orientation:
Minus strand

Genomic View for TRPV1 Gene

Genes around TRPV1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPV1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPV1 Gene

Proteins for TRPV1 Gene

  • Protein details for TRPV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NER1-TRPV1_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily V member 1
    Protein Accession:
    Q8NER1
    Secondary Accessions:
    • A2RUA9
    • Q3LU47
    • Q9H0G9
    • Q9H303
    • Q9H304
    • Q9NQ74
    • Q9NY22

    Protein attributes for TRPV1 Gene

    Size:
    839 amino acids
    Molecular mass:
    94956 Da
    Quaternary structure:
    • Interacts with PIRT (By similarity). Homotetramer (By similarity). Interacts with TRPV3 and may also form a heteromeric channel with TRPV3 (PubMed:12077606). Interacts with CALM, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity). Interacts with the Scolopendra mutilans RhTx toxin (By similarity). Interacts with TMEM100 (By similarity). Interacts with PACS2 (PubMed:29656858).
    Miscellaneous:
    • Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.
    SequenceCaution:
    • Sequence=AAG43467.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for TRPV1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPV1 Gene

Post-translational modifications for TRPV1 Gene

  • Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
  • Glycosylation at Asn604
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for TRPV1

No data available for DME Specific Peptides for TRPV1 Gene

Domains & Families for TRPV1 Gene

Gene Families for TRPV1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Protein Domains for TRPV1 Gene

Suggested Antigen Peptide Sequences for TRPV1 Gene

GenScript: Design optimal peptide antigens:
  • Transient receptor potential cation channel subfamily V member 1 transcript variant A (Q09HS5_HUMAN)
  • Transient receptor potential vanilloid 1b (Q3LU46_HUMAN)
  • Transient receptor potential vanilloid 1a (Q3LU47_HUMAN)
  • Vanilloid receptor variant TRPV1b (Q52PU4_HUMAN)
  • Vanilloid receptor 1 (TRPV1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NER1

UniProtKB/Swiss-Prot:

TRPV1_HUMAN :
  • The association domain (AD) is necessary for self-association.
  • Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
Domain:
  • The association domain (AD) is necessary for self-association.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
genes like me logo Genes that share domains with TRPV1: view

Function for TRPV1 Gene

Molecular function for TRPV1 Gene

UniProtKB/Swiss-Prot Function:
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
UniProtKB/Swiss-Prot EnzymeRegulation:
Channel activity is activated via the interaction with PIRT and phosphatidylinositol 4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity (By similarity). The channel is sensitized by ATP binding. Repeated stimulation with capsaicin gives rise to progressively smaller responses, due to desensitization. This desensitization is triggered by the influx of calcium ions and is inhibited by elevated ATP levels. Ca(2+) and CALM displace ATP from its binding site and trigger a conformation change that leads to a closed, desensitized channel. Intracellular PIP2 inhibits desensitization. The double-knot toxin (DkTx) from the Chinese earth tiger tarantula activates the channel and traps it in an open conformation (By similarity). The Scolopendra mutilans RhTx toxin potentiates the heat activation pathway mediated by this channel by binding to the charge-rich outer pore region (in an activated state) (By similarity).

Gene Ontology (GO) - Molecular Function for TRPV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004888 transmembrane signaling receptor activity ISS --
GO:0005216 ion channel activity IEA,IBA 21873635
GO:0005230 extracellular ligand-gated ion channel activity IDA 11226139
GO:0005231 excitatory extracellular ligand-gated ion channel activity ISS --
genes like me logo Genes that share ontologies with TRPV1: view
genes like me logo Genes that share phenotypes with TRPV1: view

Animal Models for TRPV1 Gene

MGI Knock Outs for TRPV1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPV1 Gene

Localization for TRPV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPV1 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO:0000250 UniProtKB:O35433}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPV1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 3
nucleus 3
cytosol 3
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRPV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS,TAS --
genes like me logo Genes that share ontologies with TRPV1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRPV1 Gene

Pathways & Interactions for TRPV1 Gene

genes like me logo Genes that share pathways with TRPV1: view

Pathways by source for TRPV1 Gene

1 GeneGo (Thomson Reuters) pathway for TRPV1 Gene
  • Neurophysiological process PGE2-induced pain processing
1 Qiagen pathway for TRPV1 Gene
  • Intracellular Calcium Signaling

SIGNOR curated interactions for TRPV1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRPV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001659 temperature homeostasis IEA --
GO:0001660 fever generation IEA --
GO:0001774 microglial cell activation IEA --
GO:0002024 diet induced thermogenesis IEA --
genes like me logo Genes that share ontologies with TRPV1: view

Drugs & Compounds for TRPV1 Gene

(151) Drugs for TRPV1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capsaicin Approved Pharma Potentiation, Activator, activator, Target, agonist TRPV1 receptor agonist 215
Acetaminophen Approved Pharma Target, activator 1285
Camphor Approved Pharma Activator, Target, agonist, activator 10
Zucapsaicin Approved, Investigational Pharma Target, agonist, activator 0
alpha-linolenic acid Approved, Investigational Nutra Full agonist, Agonist, Target 0

(29) Additional Compounds for TRPV1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]resiniferatoxin
12S-HPETE
Activator
15S-HPETE
Activator
AMG628
Channel blocker
DkTx
Irreversible agonist, Activator

(5) Tocris Compounds for TRPV1 Gene

Compound Action Cas Number
(E)-Capsaicin Prototypic vanilloid receptor agonist 404-86-4
Capsazepine Vanilloid receptor antagonist; also activator of ENaCdelta 138977-28-3
Olvanil Potent vanilloid receptor agonist 58493-49-5
Resiniferatoxin Potent vanilloid receptor agonist 57444-62-9
STEARDA Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors 105955-10-0

(45) ApexBio Compounds for TRPV1 Gene

Compound Action Cas Number
5'-Iodoresiniferatoxin 535974-91-5
6-Iodonordihydrocapsaicin Vanilloid receptor antagonist 859171-97-4
6'-Iodoresiniferatoxin 335151-55-8
9-Phenanthrol 484-17-3
A 784168 TRPV1 antagonist,potent and selective 824982-41-4
AMG 9810 TRPV1 antagonist 545395-94-6
AMG-517 TRPV1 antagonist,potent and highly selective 659730-32-2
AMTB hydrochloride 926023-82-7
BCTC 393514-24-4
Capsaicin TRPV1 receptor agonist 404-86-4
Capsazepine TRPV1 ion channel activator 138977-28-3
EIPA 1154-25-2
GSK 2193874 1336960-13-4
GsMTx4
HC 067047 883031-03-6
HC-030031 TRPA1 channel blocker,potent and selective 349085-38-7
JNJ 17203212 821768-06-3
L-R4W2 206350-79-0
mavatrep TRPV1 antagonist 956274-94-5
ML 204 5465-86-1
ML SA1 332382-54-4
Nonivamide 2444-46-4
OLDA 105955-11-1
Olvanil 58493-49-5
Ononetin 487-49-0
Optovin 348575-88-2
PALDA 136181-87-8
Phenamil 1161-94-0
Polygodial 6754-20-7
PPAHV 175796-50-6
Pyr3 1160514-60-2
Resiniferatoxin 57444-62-9
RN 1734 946387-07-1
RN 1747 1024448-59-6
SB 366791 472981-92-3
SB 452533 459429-39-1
SB705498 TRPV1 antagonist,potent and selective 501951-42-4
SN 2 823218-99-1
STEARDA 105955-10-0
TC-I 2000 1159996-20-9
TCS 5861528 332117-28-9
TRPC6 inhibitor 1333207-63-8
WS 12 68489-09-8
WS 3 39711-79-0
α-Spinasterol 481-18-5
genes like me logo Genes that share compounds with TRPV1: view

Drug Products

Transcripts for TRPV1 Gene

mRNA/cDNA for TRPV1 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPV1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c · 17d
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: - - -
SP6:

Relevant External Links for TRPV1 Gene

GeneLoc Exon Structure for
TRPV1

Expression for TRPV1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPV1 Gene

This gene is overexpressed in Artery - Tibial (x6.3).

Protein differential expression in normal tissues from HIPED for TRPV1 Gene

This gene is overexpressed in Plasma (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRPV1 Gene



Protein tissue co-expression partners for TRPV1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRPV1

SOURCE GeneReport for Unigene cluster for TRPV1 Gene:

Hs.655380

mRNA Expression by UniProt/SwissProt for TRPV1 Gene:

Q8NER1-TRPV1_HUMAN
Tissue specificity: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).

Evidence on tissue expression from TISSUES for TRPV1 Gene

  • Nervous system(4.7)
  • Pancreas(4.2)
  • Skin(2.5)
  • Intestine(2.2)
  • Muscle(2.2)
  • Blood(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with TRPV1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPV1 Gene

Orthologs for TRPV1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPV1 30
  • 99.18 (n)
-- 31
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TRPV1 30
  • 88.1 (n)
-- 31
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRPV1 31 30
  • 87.95 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trpv1 30
  • 85.9 (n)
mouse
(Mus musculus)
Mammalia Trpv1 17 31 30
  • 85.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRPV1 31 30
  • 69.06 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia trpv1 30
  • 64.47 (n)
zebrafish
(Danio rerio)
Actinopterygii trpv1 31 30
  • 59.76 (n)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10404 30
fruit fly
(Drosophila melanogaster)
Insecta nan 31
  • 19 (a)
ManyToMany
iav 31
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ocr-4 31
  • 20 (a)
ManyToMany
ocr-3 31
  • 19 (a)
ManyToMany
ocr-1 31
  • 18 (a)
ManyToMany
ocr-2 31
  • 18 (a)
ManyToMany
osm-9 31 32
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Species where no ortholog for TRPV1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRPV1 Gene

ENSEMBL:
Gene Tree for TRPV1 (if available)
TreeFam:
Gene Tree for TRPV1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRPV1: view image

Paralogs for TRPV1 Gene

Paralogs for TRPV1 Gene

(6) SIMAP similar genes for TRPV1 Gene using alignment to 9 proteins:

  • TRPV1_HUMAN
  • E7EQ78_HUMAN
  • E7ESJ2_HUMAN
  • I3L1R6_HUMAN
  • J3QK85_HUMAN
  • Q09HS5_HUMAN
  • Q3LU46_HUMAN
  • Q3LU47_HUMAN
  • Q52PU4_HUMAN
genes like me logo Genes that share paralogs with TRPV1: view

Variants for TRPV1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRPV1 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs1567672200 Uncertain Significance: not provided 3,592,288(-) G/T NONSENSE
rs161380 Benign: Nephropathic cystinosis 3,601,032(-) A/G INTRON_VARIANT
rs17633288 - p.Thr505Ala
rs222747 - p.Met315Ile
rs222749 - p.Pro91Ser

Additional dbSNP identifiers (rs#s) for TRPV1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRPV1 Gene

Variant ID Type Subtype PubMed ID
dgv3085n100 CNV loss 25217958
dgv358n27 CNV loss 19166990
dgv5423n54 CNV loss 21841781
dgv556e214 CNV loss 21293372
dgv882e212 CNV loss 25503493
esv2639824 CNV insertion 19546169
esv2662311 CNV deletion 23128226
esv2662762 CNV deletion 23128226
esv2665638 CNV deletion 23128226
esv2715530 CNV deletion 23290073
esv2762588 CNV loss 21179565
esv3572354 CNV gain 25503493
esv3639746 CNV loss 21293372
esv3639748 CNV gain 21293372
esv3639749 CNV gain 21293372
esv3639750 CNV loss 21293372
esv3639751 CNV loss 21293372
esv3639752 CNV loss 21293372
esv3639753 CNV loss 21293372
esv3892950 CNV loss 25118596
esv3892951 CNV gain 25118596
nsv1055740 CNV gain 25217958
nsv1060071 CNV loss 25217958
nsv1065489 CNV gain 25217958
nsv516676 CNV gain+loss 19592680
nsv526175 CNV gain 19592680
nsv574237 CNV loss 21841781
nsv574238 CNV loss 21841781

Variation tolerance for TRPV1 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.00; 0.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPV1 Gene

Human Gene Mutation Database (HGMD)
TRPV1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPV1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPV1 Gene

Disorders for TRPV1 Gene

MalaCards: The human disease database

(54) MalaCards diseases for TRPV1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
somatoform disorder
  • physiological malfunction arising from mental factor
burning mouth syndrome
  • orodynia
bladder disease
  • urinary bladder disease
dentin sensitivity
  • sensitive dentin
cystinosis
  • cystine storage disease
- elite association - COSMIC cancer census association via MalaCards
Search TRPV1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRPV1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRPV1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPV1 Gene

Publications for TRPV1 Gene

  1. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. (PMID: 14987252) Ständer S … Steinhoff M (Experimental dermatology 2004) 3 4 23 54
  2. Molecular determinants of vanilloid sensitivity in TRPV1. (PMID: 14996838) Gavva NR … Treanor JJ (The Journal of biological chemistry 2004) 3 4 23 54
  3. Pharmacological differences between the human and rat vanilloid receptor 1 (VR1). (PMID: 11226139) McIntyre P … James IF (British journal of pharmacology 2001) 3 4 23 54
  4. The tissue distribution and functional characterization of human VR1. (PMID: 11243859) Cortright DN … White G (Biochemical and biophysical research communications 2001) 3 4 23 54
  5. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. (PMID: 11050376) Hayes P … Davis JB (Pain 2000) 3 4 23 54

Products for TRPV1 Gene

Sources for TRPV1 Gene