TRPT1 Gene (Protein Coding)

TRNA Phosphotransferase 1

GC11M064223
GIFtS:
34
See more...

Aliases for TRPT1 Gene

Aliases for TRPT1 Gene

  • TRNA Phosphotransferase 1 2 3 5
  • TRNA Splicing 2' Phosphotransferase 1 2 3
  • TRNA 2'-Phosphotransferase 1 3 4
  • EC 2.7.1.160 4
  • MGC11134 2
  • TRPT1 5

External Ids for TRPT1 Gene

Previous GeneCards Identifiers for TRPT1 Gene

  • GC00U911626
  • GC11M063748
  • GC11M063991
  • GC11M060319

Summaries for TRPT1 Gene

GeneCards Summary for TRPT1 Gene

TRPT1 (TRNA Phosphotransferase 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and tRNA 2'-phosphotransferase activity.

UniProtKB/Swiss-Prot Summary for TRPT1 Gene

  • Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

Gene Wiki entry for TRPT1 Gene

Additional gene information for TRPT1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRPT1 Gene

Genomics for TRPT1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TRPT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRPT1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRPT1

Top Transcription factor binding sites by QIAGEN in the TRPT1 gene promoter:
  • CP2
  • ER-alpha
  • NF-kappaB1
  • Pax-5
  • SEF-1 (1)

Genomic Locations for TRPT1 Gene

Latest Assembly
chr11:64,223,799-64,226,254
(GRCh38/hg38)
Size:
2,456 bases
Orientation:
Minus strand

Previous Assembly
chr11:63,991,271-63,993,658
(GRCh37/hg19 by Entrez Gene)
Size:
2,388 bases
Orientation:
Minus strand

chr11:63,991,271-63,993,726
(GRCh37/hg19 by Ensembl)
Size:
2,456 bases
Orientation:
Minus strand

Genomic View for TRPT1 Gene

Genes around TRPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPT1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TRPT1 Gene

Proteins for TRPT1 Gene

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  • Protein details for TRPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TN4-TRPT1_HUMAN
    Recommended name:
    tRNA 2'-phosphotransferase 1
    Protein Accession:
    Q86TN4
    Secondary Accessions:
    • A8MU17
    • A8MYC9
    • F5H2B2
    • Q9BSB9

    Protein attributes for TRPT1 Gene

    Size:
    253 amino acids
    Molecular mass:
    27742 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPT1 Gene

Protein Expression for TRPT1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TRPT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRPT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRPT1 Gene

Domains & Families for TRPT1 Gene

Gene Families for TRPT1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TRPT1 Gene

InterPro:
Blocks:
  • Phosphotransferase KptA/Tpt1
ProtoNet:

Suggested Antigen Peptide Sequences for TRPT1 Gene

GenScript: Design optimal peptide antigens:
  • tRNA 2'-phosphotransferase 1 (TRPT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86TN4

UniProtKB/Swiss-Prot:

TRPT1_HUMAN :
  • Belongs to the KptA/TPT1 family.
Family:
  • Belongs to the KptA/TPT1 family.
genes like me logo Genes that share domains with TRPT1: view

Function for TRPT1 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for TRPT1 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2'-phospho-[ligated tRNA] + NAD(+) = ADP-D-ribose 1'',2''-cyclic phosphate + mature tRNA + nicotinamide; Xref=Rhea:RHEA:23324, Rhea:RHEA-COMP:11106, Rhea:RHEA-COMP:11107, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:76596, ChEBI:CHEBI:82883, ChEBI:CHEBI:85027; EC=2.7.1.160;.

Enzyme Numbers (IUBMB) for TRPT1 Gene

Phenotypes From GWAS Catalog for TRPT1 Gene

Gene Ontology (GO) - Molecular Function for TRPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000215 tRNA 2'-phosphotransferase activity IEA,IBA 21873635
GO:0003674 molecular_function ND --
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0005515 protein binding IPI --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRPT1: view
genes like me logo Genes that share phenotypes with TRPT1: view

Animal Models for TRPT1 Gene

MGI Knock Outs for TRPT1:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPT1

Clone products for research

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TRPT1 Gene

Localization for TRPT1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPT1 gene
Compartment Confidence
mitochondrion 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRPT1 Gene

Pathways & Interactions for TRPT1 Gene

PathCards logo

SuperPathways for TRPT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation IBA 21873635
GO:0008033 tRNA processing IBA 21873635
GO:0008150 biological_process ND --
GO:0045859 regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with TRPT1: view

No data available for Pathways by source and SIGNOR curated interactions for TRPT1 Gene

Drugs & Compounds for TRPT1 Gene

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  1. Drug products for research

(3) Drugs for TRPT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 466,466
Water Approved Pharma 0
NAD Experimental Pharma 0

(1) Additional Compounds for TRPT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP-ribose 2'-phosphate
  • ADP-Ribose 2'-phosphoric acid
  • 2'-Phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate]
  • ADP-D-Ribose 2'-phosphate
  • ADPribose 2'-phosphate
  • {[(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-[({[({[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-4-hydroxyoxolan-3-yl]oxy}phosphonate
 4197-14-2
genes like me logo Genes that share compounds with TRPT1: view

Transcripts for TRPT1 Gene

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  2. miRNA products for research
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mRNA/cDNA for TRPT1 Gene

7 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPT1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for TRPT1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7:
SP8: - - -
SP9: -
SP10:
SP11:

Relevant External Links for TRPT1 Gene

GeneLoc Exon Structure for
TRPT1

Expression for TRPT1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPT1 Gene

mRNA expression in normal human tissues for TRPT1 Gene
mRNA expression by BioGPS for TRPT1 GenemRNA expression by GTEx for TRPT1 Gene

mRNA differential expression in normal tissues according to GTEx for TRPT1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for TRPT1 Gene

This gene is overexpressed in Breast (29.3) and Lung (23.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRPT1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRPT1

SOURCE GeneReport for Unigene cluster for TRPT1 Gene:

Hs.326586

mRNA Expression by UniProt/SwissProt for TRPT1 Gene:

Q86TN4-TRPT1_HUMAN
Tissue specificity: Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for TRPT1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TRPT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPT1 Gene

Orthologs for TRPT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRPT1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TRPT1 30 31
  • 99.48 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TRPT1 30 31
  • 87.22 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TRPT1 30 31
  • 87.22 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Trpt1 30 17 31
  • 84.95 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Trpt1 30
  • 84.75 (n)
Oppossum
(Monodelphis domestica)
 Mammalia TRPT1 31
  • 71 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TRPT1 31
  • 63 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TRPT1 31
  • 64 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia trpt1 30
  • 59.36 (n)
Zebrafish
(Danio rerio)
 Actinopterygii trpt1 30 31
  • 57.53 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.2923 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG33057 30 31
  • 47.06 (n)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes TPT1 31 33
  • 33 (a)
 OneToOne
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons emb1067 30
  • 48.13 (n)
Rice
(Oryza sativa)
 Liliopsida Os06g0134050 30
  • 49 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAC2C4.12c 30
  • 48.64 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 40 (a)
 OneToMany
-- 31
  • 28 (a)
 OneToMany
Species where no ortholog for TRPT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TRPT1 Gene

ENSEMBL:
Gene Tree for TRPT1 (if available)
TreeFam:
Gene Tree for TRPT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRPT1: view image

Paralogs for TRPT1 Gene

No data available for Paralogs for TRPT1 Gene

Variants for TRPT1 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRPT1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1059440 - p.His172Arg
rs11549690 - p.Arg221Cys
rs12788168 - p.Phe3Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRPT1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRPT1 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv992196 CNV deletion 20482838
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366

Variation tolerance for TRPT1 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.29; 81.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPT1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPT1 Gene

Disorders for TRPT1 Gene

Additional Disease Information for TRPT1

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for TRPT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRPT1 Gene

Publications for TRPT1 Gene

  1. A human homolog of the yeast gene encoding tRNA 2'-phosphotransferase: cloning, characterization and complementation analysis. (PMID: 14504659) Hu QD … Li YY (Cellular and molecular life sciences : CMLS 2003) 2 3 4
  2. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E … Faraone SV (Journal of the American Academy of Child and Adolescent Psychiatry 2011) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. (PMID: 30862715) Liu C … Buckhaults PJ (Cancer research 2019) 3

ExternalLinks

View latest publications for TRPT1 gene in Mastermind

Products for TRPT1 Gene

Sources for TRPT1 Gene