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TRPM8 (Transient Receptor Potential Cation Channel Subfamily M Member 8) is a Protein Coding gene. Diseases associated with TRPM8 include Migraine Without Aura and Dentin Sensitivity. Among its related pathways are CREB Pathway and TRP channels. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and calcium channel activity. An important paralog of this gene is TRPM2.
The melastatin-related receptor family (TRPM) is the largest subfamily of the transient receptor potential (TRP) superfamily of ion channels. It contains 8 known members, subdivided into 4 groups, which perform a range of functions including detection of taste and osmolarity.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J233929 | Promoter/Enhancer | 0.7 | EPDnew Ensembl | 600.4 | +12.5 | 12455 | 0.8 | CTCF SP1 | TRPM8 ENSG00000237581 SPP2 | |
GH02J233917 | Promoter | 0.3 | EPDnew | 600.7 | +0.0 | 16 | 0.1 | TRPM8 ENSG00000237581 SPP2 | ||
GH02J233919 | Promoter | 0.3 | Ensembl | 600.7 | +0.2 | 159 | 0.2 | TRPM8 ENSG00000237581 SPP2 | ||
GH02J233921 | Enhancer | 0.2 | Ensembl | 600.7 | +0.6 | 559 | 0.2 | TRPM8 ENSG00000237581 SPP2 | ||
GH02J234482 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 9 | +573.7 | 573733 | 16.8 | RNF2 CREB1 ATF7 ZNF629 RFX1 JUND PRDM1 POLR2A TCF12 CTCF | ARL4C TRPM8 lnc-HJURP-12 MN297772 lnc-SPP2-10 HSALNG0023163 SPP2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005216 | ion channel activity | IEA | -- |
GO:0005262 | calcium channel activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25559186 |
GO:0042802 | identical protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
GO:0005886 | plasma membrane | IDA,TAS | -- |
GO:0009897 | external side of plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Ion channel transport | ||
2 | Development Endothelin-1/EDNRA signaling | ||
3 | CREB Pathway |
Intracellular Calcium Signaling
.50
|
|
4 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
5 | TRP channels |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006811 | ion transport | IEA | -- |
GO:0006812 | cation transport | IEA | -- |
GO:0006816 | calcium ion transport | IEA | -- |
GO:0006874 | cellular calcium ion homeostasis | IEA | -- |
GO:0009266 | response to temperature stimulus | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Menthol | Approved | Pharma | Activator, Activation, Partial agonist, Target, inducer, activator | 148 | ||
cannabidiol | Approved, Investigational | Pharma | Agonist, Partial agonist, Antagonist, Channel blocker, Activator, Target | 0 | ||
Clotrimazole | Approved, Vet_approved | Pharma | Pore Blocker, Inhibition, Agonist, Antagonist, Channel blocker, Gating inhibitor, inhibitor | 3024 | ||
linoleic acid | Approved, Experimental | Pharma | Agonist, Full agonist, Activator, Pore Blocker, Channel blocker | 0 | ||
Camphor | Approved | Pharma | Activator, Target, activator | 10 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
WS-12 |
|
Activator |
|
|
||
sodium |
|
7440-23-5 |
|
|||
CIM 0216 |
|
1031496-06-6 |
|
|
||
TC-I 2014 |
|
1221349-53-6 |
|
|
Compound | Action | Cas Number |
---|---|---|
CIM 0216 | Selective TRPM3 agonist | 1031496-06-6 |
RQ 00203078 | Potent and selective TRPM8 antagonist; orally active | 1254205-52-1 |
TC-I 2014 | Potent TRPM8 antagonist | 1221349-53-6 |
WS 12 | TRPM8 agonist; cooling agent | 68489-09-8 |
WS 3 | TRPM8 agonist; cooling agent | 39711-79-0 |
Compound | Action | Cas Number |
---|---|---|
5'-Iodoresiniferatoxin | 535974-91-5 | |
6'-Iodoresiniferatoxin | 335151-55-8 | |
9-Phenanthrol | 484-17-3 | |
AMTB hydrochloride | 926023-82-7 | |
BCTC | 393514-24-4 | |
EIPA | 1154-25-2 | |
GSK 2193874 | 1336960-13-4 | |
GsMTx4 | ||
HC 067047 | 883031-03-6 | |
Icilin | TRPM8/ hENaCδ agonist | 36945-98-9 |
JNJ 17203212 | 821768-06-3 | |
L-R4W2 | 206350-79-0 | |
ML 204 | 5465-86-1 | |
ML SA1 | 332382-54-4 | |
OLDA | 105955-11-1 | |
Olvanil | 58493-49-5 | |
Ononetin | 487-49-0 | |
PALDA | 136181-87-8 | |
Phenamil | 1161-94-0 | |
Polygodial | 6754-20-7 | |
PPAHV | 175796-50-6 | |
Pyr3 | 1160514-60-2 | |
RN 1734 | 946387-07-1 | |
RQ-00203078 | Selective and orally active TRPM8 antagonist | 1254205-52-1 |
SB 366791 | 472981-92-3 | |
SB 452533 | 459429-39-1 | |
STEARDA | 105955-10-0 | |
TC-I 2000 | 1159996-20-9 | |
TCS 5861528 | 332117-28-9 | |
TRPC6 inhibitor | 1333207-63-8 | |
WS 12 | 68489-09-8 | |
WS 3 | 39711-79-0 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: |
ExUns: | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||
SP2: | |||||||||||||||||
SP3: | |||||||||||||||||
SP4: | |||||||||||||||||
SP5: | |||||||||||||||||
SP6: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TRPM8 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TRPM8 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TRPM8 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TRPM8 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TRPM8 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Trpm8 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Trpm8 30 |
|
||
Chicken (Gallus gallus) |
Aves | TRPM8 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TRPM8 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | trpm8 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | trpm 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | gtl-2 31 |
|
ManyToMany | |
gtl-1 31 |
|
ManyToMany | |||
gon-2 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
716303 | Benign: not provided | 233,954,006(+) | C/T | SYNONYMOUS_VARIANT | |
721898 | Likely Benign: not provided | 233,960,768(+) | C/T | INTRON_VARIANT | |
723767 | Likely Benign: not provided | 233,926,549(+) | G/A | SYNONYMOUS_VARIANT | |
727971 | Likely Benign: not provided | 233,930,676(+) | G/T | SYNONYMOUS_VARIANT | |
742947 | Likely Benign: not provided | 233,966,603(+) | G/A | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1220e212 | CNV | loss | 25503493 |
nsv1013712 | CNV | loss | 25217958 |
nsv475378 | CNV | novel sequence insertion | 20440878 |
nsv476571 | CNV | novel sequence insertion | 20440878 |
nsv953206 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
migraine without aura |
|
|
dentin sensitivity |
|
|
diabetic neuropathy |
|
|
prostate cancer |
|
|
lichen sclerosus et atrophicus |
|
|