Aliases for TRPM7 Gene
External Ids for TRPM7 Gene
Previous GeneCards Identifiers for TRPM7 Gene
This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]
GeneCards Summary for TRPM7 Gene
TRPM7 (Transient Receptor Potential Cation Channel Subfamily M Member 7) is a Protein Coding gene. Diseases associated with TRPM7 include Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1 and Lateral Sclerosis. Among its related pathways are Mineral absorption and Cellular senescence (KEGG). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and actin binding. An important paralog of this gene is TRPM6.
UniProtKB/Swiss-Prot Summary for TRPM7 Gene
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).