The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcr... See more...

Aliases for TRPM2 Gene

Aliases for TRPM2 Gene

  • Transient Receptor Potential Cation Channel Subfamily M Member 2 2 3 4 5
  • LTRPC2 2 3 4
  • EREG1 2 3 4
  • KNP3 2 3 4
  • Estrogen-Responsive Element-Associated Gene 1 Protein 3 4
  • Long Transient Receptor Potential Channel 2 3 4
  • Transient Receptor Potential Melastatin 2 3 4
  • Transient Receptor Potential Channel 7 3 4
  • LTrpC-2 3 4
  • NUDT9L1 2 3
  • NUDT9H 2 3
  • TRPC7 3 4
  • Transient Receptor Potential Cation Channel, Subfamily M, Member 2 2
  • LTrpC2 4
  • TRPM2 5
  • TrpC7 4

External Ids for TRPM2 Gene

Previous HGNC Symbols for TRPM2 Gene

  • TRPC7

Previous GeneCards Identifiers for TRPM2 Gene

  • GC21P042282
  • GC21P044629
  • GC21P044597
  • GC21P045770
  • GC21P031143

Summaries for TRPM2 Gene

Entrez Gene Summary for TRPM2 Gene

  • The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]

GeneCards Summary for TRPM2 Gene

TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2) is a Protein Coding gene. Diseases associated with TRPM2 include Alzheimer Disease 9 and Progressive Familial Heart Block. Among its related pathways are Innate Immune System and Ectoderm Differentiation. Gene Ontology (GO) annotations related to this gene include hydrolase activity and calcium channel activity. An important paralog of this gene is TRPM5.

UniProtKB/Swiss-Prot Summary for TRPM2 Gene

  • [Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:28775320, PubMed:29745897, PubMed:30467180). Functions as ligand-gated ion channel (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular calcium passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606).
  • [Isoform 2]: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose.
  • [Isoform 3]: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress.

Gene Wiki entry for TRPM2 Gene

Additional gene information for TRPM2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRPM2 Gene

Genomics for TRPM2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRPM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J044424 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 607 +75.8 75794 2.2 POLR2A ZFX SMARCC1 CEBPB RCOR1 GABPA GTF2F1 MAX MXI1 ZFHX2 TRPM2 TRPM2-AS CFAP410 piR-35674-329 LRRC3
GH21J044349 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 630.7 +2.6 2628 6.3 CEBPG SP1 CREB1 ZBTB33 ZNF143 POLR2A CEBPA EED CEBPB TCF7 TRPM2 CFAP410 piR-49452 LRRC3
GH21J044368 Promoter 0.6 EPDnew 600.4 +18.9 18899 0.1 ZBTB48 CTCF GLIS2 TRPM2 TSPEAR-AS1 piR-49452 RF00017-3731 LRRC3
GH21J043724 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.2 -617.1 -617105 17.6 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ZBTB33 PRDM10 ZNF629 LEF1 SOX13 PDXK RRP1B WDR4 ENSG00000233754 PWP2 U2AF1 HSF2BP TRPM2 TRAPPC10 ENSG00000184441
GH21J044916 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.7 +574.9 574902 17.6 RNF2 SP1 HNRNPL CREB1 ATF7 ZNF512 IKZF1 CTCF POLR2A BACH1 ITGB2-AS1 FAM207A ITGB2 POFUT2 UBE2G2 ENSG00000273027 TRPM2 PTTG1IP LINC01547 PWP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRPM2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRPM2

Top Transcription factor binding sites by QIAGEN in the TRPM2 gene promoter:
  • AML1a
  • c-Myb
  • HSF1 (long)
  • HSF1short
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Spz1
  • STAT5A
  • YY1

Genomic Locations for TRPM2 Gene

Genomic Locations for TRPM2 Gene
chr21:44,350,112-44,443,081
(GRCh38/hg38)
Size:
92,970 bases
Orientation:
Plus strand
chr21:45,770,046-45,862,964
(GRCh37/hg19)
Size:
92,919 bases
Orientation:
Plus strand

Genomic View for TRPM2 Gene

Genes around TRPM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPM2 Gene

Proteins for TRPM2 Gene

  • Protein details for TRPM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94759-TRPM2_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily M member 2
    Protein Accession:
    O94759
    Secondary Accessions:
    • D3DSL6
    • Q5KTC2
    • Q6J3P5
    • Q96KN6
    • Q96Q93

    Protein attributes for TRPM2 Gene

    Size:
    1503 amino acids
    Molecular mass:
    171198 Da
    Quaternary structure:
    • Homotetramer (PubMed:30467180). Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death.
    SequenceCaution:
    • Sequence=BAB64300.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRPM2 Gene

    Alternative splice isoforms for TRPM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPM2 Gene

Post-translational modifications for TRPM2 Gene

  • Ubiquitination at Lys307
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRPM2 Gene

Domains & Families for TRPM2 Gene

Gene Families for TRPM2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for TRPM2 Gene

InterPro:
Blocks:
  • NUDIX hydrolase
  • Transient receptor potential family signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRPM2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50244, highly similar to Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (B4DVI8_HUMAN)
  • TRPM2 protein (Q14DR2_HUMAN)
  • Transient receptor potential cation channel, subfamily M, member 2, striatum short form (SSF-TRPM2) (Q5KTC1_HUMAN)
  • Transient receptor potential channel 7 (TRPM2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O94759

UniProtKB/Swiss-Prot:

TRPM2_HUMAN :
  • The cytosolic nudix box binds ADP-ribose and is required for channel activation by ADP-ribose (PubMed:15561722, PubMed:16601673, PubMed:30467180).
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
Domain:
  • The cytosolic nudix box binds ADP-ribose and is required for channel activation by ADP-ribose (PubMed:15561722, PubMed:16601673, PubMed:30467180).
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.
genes like me logo Genes that share domains with TRPM2: view

Function for TRPM2 Gene

Molecular function for TRPM2 Gene

UniProtKB/Swiss-Prot Function:
[Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:28775320, PubMed:29745897, PubMed:30467180). Functions as ligand-gated ion channel (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular calcium passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606).
UniProtKB/Swiss-Prot Function:
[Isoform 2]: Lacks cation channel activity. Does not mediate cation transport in response to oxidative stress or ADP-ribose.
UniProtKB/Swiss-Prot Function:
[Isoform 3]: Lacks cation channel activity and negatively regulates the channel activity of isoform 1. Negatively regulates susceptibility to cell death in reposponse to oxidative stress.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inactivated by exposure to extracellular pH between 4.0 and 6.5; irreversibly inactivated when open channels are exposed to extracellular pH between 4.0 and 6.5, while pre-exposure of closed channels to extracellular pH 5.5 gives rise to currents that rapidly inactivate, but protects against irreversible inactivation (PubMed:20660597). Inactivated by intracellular ATP (PubMed:11509734). Activated by arachidonic acid (PubMed:11804595). Inhibited by 2-aminoethyl diphenylborinate (2-APB) (PubMed:28775320).

Phenotypes From GWAS Catalog for TRPM2 Gene

Gene Ontology (GO) - Molecular Function for TRPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005261 cation channel activity IEA,IMP 27068538
GO:0005262 calcium channel activity TAS 9806837
GO:0005272 sodium channel activity IEA --
GO:0005384 manganese ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with TRPM2: view
genes like me logo Genes that share phenotypes with TRPM2: view

Animal Models for TRPM2 Gene

MGI Knock Outs for TRPM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPM2

CRISPR Products

miRNA for TRPM2 Gene

miRTarBase miRNAs that target TRPM2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPM2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPM2 Gene

Localization for TRPM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPM2 Gene

Cell membrane. Multi-pass membrane protein. Perikaryon. Cell projection. Cytoplasmic vesicle. Lysosome. Note=Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils. Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (By similarity). {ECO:0000250 UniProtKB:E9PTA2, ECO:0000250 UniProtKB:Q91YD4}.
[Isoform 1]: Cell membrane. Multi-pass membrane protein.
[Isoform 2]: Cell membrane. Multi-pass membrane protein.
[Isoform 3]: Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPM2 gene
Compartment Confidence
plasma membrane 5
lysosome 5
nucleus 3
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
cytoskeleton 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005764 lysosome IEA,IDA 27068538
GO:0005765 lysosomal membrane ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,ISS --
genes like me logo Genes that share ontologies with TRPM2: view

Pathways & Interactions for TRPM2 Gene

genes like me logo Genes that share pathways with TRPM2: view

Pathways by source for TRPM2 Gene

1 Qiagen pathway for TRPM2 Gene
  • Intracellular Calcium Signaling

Gene Ontology (GO) - Biological Process for TRPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis ISS --
GO:0002407 dendritic cell chemotaxis ISS --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006814 sodium ion transport IEA --
genes like me logo Genes that share ontologies with TRPM2: view

No data available for SIGNOR curated interactions for TRPM2 Gene

Drugs & Compounds for TRPM2 Gene

(22) Drugs for TRPM2 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flufenamic acid Approved Pharma Channel blocker, Inhibitor, Pore Blocker, Antagonist Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6 0
Clotrimazole Approved, Vet_approved Pharma Pore Blocker, Inhibition, Agonist, Antagonist, Channel blocker, Gating inhibitor, inhibitor 3024
Econazole Approved Pharma Channel blocker, Pore Blocker, Antagonist, inhibitor 8
Miconazole Approved, Investigational, Vet_approved Pharma Channel blocker, Pore Blocker, Antagonist, inhibitor 3024
Water Approved Pharma 0

(7) Additional Compounds for TRPM2 Gene - From: IUPHAR, Novoseek, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
H<sup>+</sup> (extracellular)
Activator, Allosteric regulator, Inhibition, Gating inhibitor, Antagonist, Channel blocker, Potentiation
Adenosine diphosphate ribose
  • (Rib5)ppa
  • 5-(Adenosine 5'-pyrophosphoryl)-D-ribose
  • a5'pp5RIb
  • Adenosine 5'-diphosphoribose
  • AdoPPRib
20762-30-5
D-Ribose 5-phosphate
  • D-Ribose 5'-phosphate
  • D-Ribose-5-P
  • Ribose 5-phosphate
  • D-Ribose 5'-phosphoric acid
  • D-Ribose 5-phosphoric acid
3615-55-2
sodium
  • Na(+)
  • Na+
  • SODIUM ion
7440-23-5
genes like me logo Genes that share compounds with TRPM2: view

Transcripts for TRPM2 Gene

mRNA/cDNA for TRPM2 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPM2

Alternative Splicing Database (ASD) splice patterns (SP) for TRPM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a ·
SP1: -
SP2:
SP3: -
SP4: -
SP5:

ExUns: 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
SP1: -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for TRPM2 Gene

GeneLoc Exon Structure for
TRPM2

Expression for TRPM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPM2 Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for TRPM2 Gene

This gene is overexpressed in Testis (56.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRPM2 Gene



Protein tissue co-expression partners for TRPM2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRPM2

SOURCE GeneReport for Unigene cluster for TRPM2 Gene:

Hs.369759

mRNA Expression by UniProt/SwissProt for TRPM2 Gene:

O94759-TRPM2_HUMAN
Tissue specificity: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes.

Evidence on tissue expression from TISSUES for TRPM2 Gene

  • Nervous system(4.6)
  • Bone marrow(4.4)
  • Heart(2.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with TRPM2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPM2 Gene

Orthologs for TRPM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPM2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRPM2 30 31
  • 98.8 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 90 (a)
OneToMany
-- 31
  • 80 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia TRPM2 31
  • 87 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia TRPM2 30
  • 85.36 (n)
-- 31
  • 80 (a)
OneToMany
-- 31
  • 78 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Trpm2 30
  • 83.79 (n)
Mouse
(Mus musculus)
Mammalia Trpm2 30 17 31
  • 83.5 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRPM2 30 31
  • 83.43 (n)
OneToOne
Chicken
(Gallus gallus)
Aves TRPM2 30 31
  • 76.27 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRPM2 31
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trpm2 30
  • 64.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii trpm2 31
  • 51 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta trpm 31
  • 20 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea gtl-2 31
  • 25 (a)
ManyToMany
gtl-1 31
  • 20 (a)
ManyToMany
gon-2 31
  • 18 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
Species where no ortholog for TRPM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRPM2 Gene

ENSEMBL:
Gene Tree for TRPM2 (if available)
TreeFam:
Gene Tree for TRPM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRPM2: view image

Paralogs for TRPM2 Gene

Paralogs for TRPM2 Gene

(7) SIMAP similar genes for TRPM2 Gene using alignment to 6 proteins:

  • TRPM2_HUMAN
  • B4DVI8_HUMAN
  • C9JZQ8_HUMAN
  • E9PGK7_HUMAN
  • Q14DR2_HUMAN
  • Q5KTC1_HUMAN
genes like me logo Genes that share paralogs with TRPM2: view

Variants for TRPM2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRPM2 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
708274 Benign: not provided 44,437,104(+) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
710986 Benign: not provided 44,437,075(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
711762 Likely Benign: not provided 44,379,013(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
712871 Likely Benign: not provided 44,440,883(+) T/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
713434 Likely Benign: not provided 44,395,542(+) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for TRPM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRPM2 Gene

Variant ID Type Subtype PubMed ID
dgv2401n106 CNV duplication 24896259
dgv2505e59 CNV duplication 20981092
dgv7887n54 CNV gain 21841781
dgv7888n54 CNV loss 21841781
dgv7889n54 CNV gain+loss 21841781
dgv7890n54 CNV loss 21841781
esv1196219 CNV deletion 17803354
esv1217346 CNV deletion 17803354
esv1238729 CNV deletion 17803354
esv1540187 CNV deletion 17803354
esv1585847 CNV deletion 17803354
esv2299983 CNV deletion 18987734
esv2310692 CNV deletion 18987734
esv23823 CNV loss 19812545
esv2549295 CNV deletion 19546169
esv2636773 CNV deletion 19546169
esv2673819 CNV deletion 23128226
esv2678126 CNV deletion 23128226
esv2723638 CNV deletion 23290073
esv2723644 CNV deletion 23290073
esv2723645 CNV deletion 23290073
esv2723646 CNV deletion 23290073
esv2723647 CNV deletion 23290073
esv2723648 CNV deletion 23290073
esv2723649 CNV deletion 23290073
esv2723651 CNV deletion 23290073
esv2723652 CNV deletion 23290073
esv2723653 CNV deletion 23290073
esv2723654 CNV deletion 23290073
esv2723655 CNV deletion 23290073
esv2723656 CNV deletion 23290073
esv2723657 CNV deletion 23290073
esv2723658 CNV deletion 23290073
esv27433 CNV gain+loss 19812545
esv27471 CNV gain 19812545
esv3375 CNV loss 18987735
esv33817 CNV loss 17666407
esv3557806 CNV deletion 23714750
esv3568215 CNV loss 25503493
esv6021 CNV loss 19470904
nsv1058359 CNV gain 25217958
nsv1071760 CNV deletion 25765185
nsv1076525 CNV duplication 25765185
nsv1114297 CNV deletion 24896259
nsv1149549 CNV deletion 26484159
nsv3539 CNV insertion 18451855
nsv509800 CNV insertion 20534489
nsv519245 CNV loss 19592680
nsv587740 CNV loss 21841781
nsv587781 CNV loss 21841781
nsv587782 CNV loss 21841781
nsv587785 CNV gain 21841781
nsv587795 CNV gain+loss 21841781
nsv587797 CNV loss 21841781
nsv587800 CNV gain 21841781
nsv587801 CNV loss 21841781
nsv817934 CNV loss 17921354
nsv953646 CNV deletion 24416366
nsv956730 CNV deletion 24416366

Variation tolerance for TRPM2 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.29; 76.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPM2 Gene

Human Gene Mutation Database (HGMD)
TRPM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPM2 Gene

Disorders for TRPM2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRPM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alzheimer disease 9
  • alzheimer disease 9, susceptibility to
progressive familial heart block
  • pccd
- elite association - COSMIC cancer census association via MalaCards
Search TRPM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRPM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRPM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPM2 Gene

Publications for TRPM2 Gene

  1. Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. (PMID: 15561722) Perraud AL … Scharenberg AM (The Journal of biological chemistry 2005) 3 4 23
  2. Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. (PMID: 15708008) Uemura T … Shimizu N (Biochemical and biophysical research communications 2005) 3 4 23
  3. A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. (PMID: 12594222) Zhang W … Miller BA (The Journal of biological chemistry 2003) 3 4 23
  4. LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. (PMID: 11804595) Hara Y … Mori Y (Molecular cell 2002) 3 4 23
  5. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (PMID: 11385575) Perraud AL … Scharenberg AM (Nature 2001) 2 3 4

Products for TRPM2 Gene

  • Signalway ELISA kits for TRPM2
  • Signalway Proteins for TRPM2

Sources for TRPM2 Gene