TRPM1 Gene (Protein Coding)

Transient Receptor Potential Cation Channel Subfamily M Member 1

GC15M031001
GIFtS:
43
This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. ... See more...

Aliases for TRPM1 Gene

Aliases for TRPM1 Gene

  • Transient Receptor Potential Cation Channel Subfamily M Member 1 2 3 4 5
  • LTRPC1 2 3 4
  • Long Transient Receptor Potential Channel 1 3 4
  • Melastatin-1 3 4
  • CSNB1C 2 3
  • MLSN1 3 4
  • Transient Receptor Potential Cation Channel, Subfamily M, Member 1 2
  • Transient Receptor Potential Melastatin Family 3
  • Melastatin 1 2
  • LTrpC1 4
  • TRPM1 5
  • MLSN 4

External Ids for TRPM1 Gene

Previous HGNC Symbols for TRPM1 Gene

  • MLSN1

Previous GeneCards Identifiers for TRPM1 Gene

  • GC15P027628
  • GC15M024049
  • GC15M028873
  • GC15M029009
  • GC15M029080
  • GC15M031293
  • GC15M008470

Summaries for TRPM1 Gene

Entrez Gene Summary for TRPM1 Gene

  • This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

GeneCards Summary for TRPM1 Gene

TRPM1 (Transient Receptor Potential Cation Channel Subfamily M Member 1) is a Protein Coding gene. Diseases associated with TRPM1 include Night Blindness, Congenital Stationary, Type 1C and Congenital Stationary Night Blindness. Among its related pathways are CREB Pathway and TRP channels. Gene Ontology (GO) annotations related to this gene include ion channel activity and cation channel activity. An important paralog of this gene is TRPM3.

UniProtKB/Swiss-Prot Summary for TRPM1 Gene

  • Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.

Gene Wiki entry for TRPM1 Gene

Additional gene information for TRPM1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRPM1 Gene

Genomics for TRPM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TRPM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH15J031101 Promoter/Enhancer 1.1 EPDnew Ensembl CraniofacialAtlas 612.8 +59.6 59574 0.6 EZH2 ZEB1 SMARCA4 GATA2 ZEB2 TRPM1 RNU6-466P MTMR10 piR-55985-053 lnc-MTMR10-1
GH15J031078 Promoter 0.5 EPDnew 600.2 +82.5 82528 0.1 POLR2A SMARCA4 TRPM1 MIR211 lnc-MTMR10-1 MTMR10
GH15J030988 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 +170.6 170629 4.7 GATAD2A HNRNPL PRDM10 REST POLR2A RCOR2 ZNF7 BACH1 LARP7 PRDM1 MTMR10 ENSG00000259720 lnc-TRPM1-2 HERC2P10 TRPM1 RNU6-466P FAN1 ENSG00000260382 ENSG00000215302
GH15J031091 Enhancer 0.9 Ensembl ENCODE 18.6 +69.1 69136 1.9 GATAD2A SOX13 RCOR2 RXRB REST CEBPA TCF7 SP1 JUND ESR1 lnc-MTMR10-1 TRPM1 MTMR10 FAN1 ENSG00000270055 MIR211
GH15J031197 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.1 -37.2 -37228 6.6 CTCF PRDM10 ZNF512 PRDM1 ZNF143 RELA REST RAD21 TRIM22 PKNOX1 ENSG00000270055 TRPM1 KLF13 HERC2P10 HSALNG0104809 piR-45471-191 LOC283710
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRPM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRPM1

Top Transcription factor binding sites by QIAGEN in the TRPM1 gene promoter:
  • AREB6
  • c-Myc
  • C/EBPbeta
  • Max1
  • MEF-2A
  • MZF-1
  • POU6F1 (c2)
  • USF-1
  • USF1

Genomic Locations for TRPM1 Gene

Genomic Locations for TRPM1 Gene
chr15:31,001,061-31,161,273
(GRCh38/hg38)
Size:
160,213 bases
Orientation:
Minus strand
chr15:31,293,264-31,453,476
(GRCh37/hg19)
Size:
160,213 bases
Orientation:
Minus strand

Genomic View for TRPM1 Gene

Genes around TRPM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPM1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TRPM1 Gene

Proteins for TRPM1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TRPM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4N2-TRPM1_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily M member 1
    Protein Accession:
    Q7Z4N2
    Secondary Accessions:
    • D9IDV2
    • D9IDV3
    • F8W865
    • H0YN37
    • O75560
    • Q6PE48
    • Q7Z4N1
    • Q7Z4N3
    • Q7Z4N4
    • Q7Z4N5

    Protein attributes for TRPM1 Gene

    Size:
    1603 amino acids
    Molecular mass:
    182178 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for TRPM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPM1 Gene

Protein Expression for TRPM1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TRPM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRPM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRPM1 Gene

Domains & Families for TRPM1 Gene

Gene Families for TRPM1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Voltage-gated ion channels

Protein Domains for TRPM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRPM1 Gene

GenScript: Design optimal peptide antigens:
  • Transient receptor potential cation channel subfamily M member 1 (C9EH86_HUMAN)
  • Transient receptor potential melastatin family isoform 1 splice variant (D9IDV2_HUMAN)
  • TRPM1 protein (Q6PE48_HUMAN)
  • Melastatin-1 (TRPM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z4N2

UniProtKB/Swiss-Prot:

TRPM1_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily.
genes like me logo Genes that share domains with TRPM1: view

Function for TRPM1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TRPM1 Gene

UniProtKB/Swiss-Prot Function:
Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.
UniProtKB/Swiss-Prot Induction:
Up-regulated by hexamethylene bisacetamide (HBMA).

Phenotypes From GWAS Catalog for TRPM1 Gene

Gene Ontology (GO) - Molecular Function for TRPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005261 cation channel activity IEA --
GO:0005262 calcium channel activity TAS,IDA 23452348
genes like me logo Genes that share ontologies with TRPM1: view
genes like me logo Genes that share phenotypes with TRPM1: view

Human Phenotype Ontology for TRPM1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRPM1 Gene

MGI Knock Outs for TRPM1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPM1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPM1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TRPM1 Gene

Localization for TRPM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPM1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPM1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
extracellular 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Centriolar satellite (1)
  • Golgi apparatus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9806836
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRPM1: view

Pathways & Interactions for TRPM1 Gene

genes like me logo Genes that share pathways with TRPM1: view

Pathways by source for TRPM1 Gene

1 Qiagen pathway for TRPM1 Gene
  • Intracellular Calcium Signaling

SIGNOR curated interactions for TRPM1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRPM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IEA --
GO:0007216 G protein-coupled glutamate receptor signaling pathway IMP 23452348
GO:0007601 visual perception IMP 19878917
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TRPM1: view

Drugs & Compounds for TRPM1 Gene

Products:

  1. Drug

(5) Drugs for TRPM1 Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
hydroxyproline Experimental Pharma 0
pregnenolone sulphate Pharma Antagonist, Activator 0
Zn<sup>2+</sup> Pharma Allosteric regulator, Negative, Positive, Channel blocker, Inhibition, Potentiation, Agonist, Pore Blocker, Antagonist 0
Calcium Nutra 6556
Proline Nutra 44
genes like me logo Genes that share compounds with TRPM1: view

Transcripts for TRPM1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TRPM1 Gene

4 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPM1

Alternative Splicing Database (ASD) splice patterns (SP) for TRPM1 Gene

No ASD Table

Relevant External Links for TRPM1 Gene

GeneLoc Exon Structure for
TRPM1

Expression for TRPM1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPM1 Gene

mRNA expression in normal human tissues for TRPM1 Gene
mRNA expression by BioGPS for TRPM1 GenemRNA expression by GTEx for TRPM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPM1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.7), Skin - Not Sun Exposed (Suprapubic) (x12.7), and Testis (x7.0).

Protein differential expression in normal tissues from HIPED for TRPM1 Gene

This gene is overexpressed in Heart (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRPM1 Gene



Protein tissue co-expression partners for TRPM1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRPM1

SOURCE GeneReport for Unigene cluster for TRPM1 Gene:

Hs.155942

mRNA Expression by UniProt/SwissProt for TRPM1 Gene:

Q7Z4N2-TRPM1_HUMAN
Tissue specificity: Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.

Evidence on tissue expression from TISSUES for TRPM1 Gene

  • Skin(3.5)
  • Eye(2.8)
  • Nervous system(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPM1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • integumentary
  • nervous
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
General:
  • blood
  • peripheral nervous system
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with TRPM1: view

Orthologs for TRPM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TRPM1 30 31
  • 99.29 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TRPM1 30 31
  • 88.16 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TRPM1 30 31
  • 86.38 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Trpm1 30
  • 83.74 (n)
Mouse
(Mus musculus)
 Mammalia Trpm1 30 17 31
  • 82.92 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TRPM1 31
  • 82 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TRPM1 31
  • 68 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TRPM1 30 31
  • 75.53 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TRPM1 31
  • 78 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia trpm1 30
  • 71.35 (n)
Zebrafish
(Danio rerio)
 Actinopterygii trpm1b 31
  • 78 (a)
 OneToMany
trpm1a 31
  • 68 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta CG30078 32
  • 44 (a)
CG30079 32
  • 44 (a)
Worm
(Caenorhabditis elegans)
 Secernentea gon-2 30
  • 51.01 (n)
Species where no ortholog for TRPM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRPM1 Gene

ENSEMBL:
Gene Tree for TRPM1 (if available)
TreeFam:
Gene Tree for TRPM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRPM1: view image

Paralogs for TRPM1 Gene

Paralogs for TRPM1 Gene

(4) SIMAP similar genes for TRPM1 Gene using alignment to 4 proteins:

  • TRPM1_HUMAN
  • C9EH86_HUMAN
  • H0YKU7_HUMAN
  • H0YM61_HUMAN
genes like me logo Genes that share paralogs with TRPM1: view

Variants for TRPM1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRPM1 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
636226 Uncertain Significance: Retinitis pigmentosa 31,050,432(-) G/A MISSENSE_VARIANT
645561 Pathogenic: not provided 31,042,072(-) G/A NONSENSE
708603 Conflicting Interpretations: Congenital stationary night blindness, type 1C; not provided 31,067,081(-) T/C SYNONYMOUS_VARIANT
708961 Conflicting Interpretations: Congenital stationary night blindness, type 1C; not provided 31,037,768(-) G/A SYNONYMOUS_VARIANT
709475 Benign/Likely Benign: Congenital stationary night blindness, type 1C; not provided 31,067,066(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TRPM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRPM1 Gene

Variant ID Type Subtype PubMed ID
dgv2534n100 CNV loss 25217958
dgv4428n54 CNV loss 21841781
esv2658003 CNV deletion 23128226
esv2678604 CNV deletion 23128226
esv2760394 CNV loss 21179565
esv2761861 CNV loss 21179565
esv33507 CNV loss 17666407
esv3581610 CNV loss 25503493
esv3581611 CNV loss 25503493
esv3581612 CNV loss 25503493
esv3636036 CNV gain 21293372
esv3636043 CNV loss 21293372
esv3636044 CNV loss 21293372
esv3636045 CNV gain 21293372
esv3636046 CNV loss 21293372
esv3636047 CNV loss 21293372
esv3636048 CNV loss 21293372
nsv1046874 CNV gain 25217958
nsv1050000 CNV loss 25217958
nsv456746 CNV loss 19166990
nsv477818 CNV novel sequence insertion 20440878
nsv520825 CNV loss 19592680
nsv525795 CNV gain 19592680
nsv568767 CNV loss 21841781
nsv820152 CNV loss 19587683
nsv832951 CNV loss 17160897
nsv832952 CNV gain+loss 17160897

Variation tolerance for TRPM1 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPM1 Gene

Human Gene Mutation Database (HGMD)
TRPM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPM1 Gene

Disorders for TRPM1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for TRPM1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
night blindness, congenital stationary, type 1c
  • csnb, complete, autosomal recessive
congenital stationary night blindness
  • congenital essential nyctalopia
fundus dystrophy
  • retinal dystrophy
inherited retinal disorder
  • retinal dystrophy
night blindness
  • nyctalopia
- elite association - COSMIC cancer census association via MalaCards
Search TRPM1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRPM1_HUMAN
  • Night blindness, congenital stationary, 1C (CSNB1C) [MIM:613216]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. {ECO:0000269 PubMed:19878917, ECO:0000269 PubMed:19896109, ECO:0000269 PubMed:19896113}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TRPM1

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRPM1: view

No data available for Genatlas for TRPM1 Gene

Publications for TRPM1 Gene

  1. Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1). (PMID: 9806836) Hunter JJ … Shyjan AW (Genomics 1998) 2 3 4 23
  2. Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans. (PMID: 19878917) Li Z … Webster AR (American journal of human genetics 2009) 3 4 23
  3. TRPM1 forms ion channels associated with melanin content in melanocytes. (PMID: 19436059) Oancea E … Clapham DE (Science signaling 2009) 3 4 23
  4. Expression and Up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells. (PMID: 11112417) Fang D … Setaluri V (Biochemical and biophysical research communications 2000) 3 4 23
  5. Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. (PMID: 9537257) Duncan LM … Shyjan AW (Cancer research 1998) 2 3 4

ExternalLinks

View latest publications for TRPM1 gene in Mastermind

Products for TRPM1 Gene

  • Addgene plasmids for TRPM1
  • Biorbyt antibodies for TRPM1

Sources for TRPM1 Gene