Aliases for TRPC7 Gene

Aliases for TRPC7 Gene

  • Transient Receptor Potential Cation Channel Subfamily C Member 7 2 3 5
  • Short Transient Receptor Potential Channel 7 3 4
  • Transient Receptor Protein 7 3 4
  • TRP7 3 4
  • Likley Ortholog Of Mouse Transient Receptor Potential Cation Channel, Subfamily C, Member 7 3
  • Transient Receptor Potential Cation Channel, Subfamily C, Member 7 2
  • Putative Capacitative Calcium Channel 3
  • TRPC7 5
  • TrpC7 4
  • TRP-7 4
  • HTRP7 4

External Ids for TRPC7 Gene

Previous GeneCards Identifiers for TRPC7 Gene

  • GC05M135424
  • GC05M135579
  • GC05M135625
  • GC05M135577
  • GC05M135549
  • GC05M130737

Summaries for TRPC7 Gene

GeneCards Summary for TRPC7 Gene

TRPC7 (Transient Receptor Potential Cation Channel Subfamily C Member 7) is a Protein Coding gene. Among its related pathways are Platelet homeostasis and RET signaling. Gene Ontology (GO) annotations related to this gene include binding and calcium channel activity. An important paralog of this gene is TRPC3.

UniProtKB/Swiss-Prot Summary for TRPC7 Gene

  • Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.

Gene Wiki entry for TRPC7 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRPC7 Gene

Genomics for TRPC7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRPC7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J136729 Enhancer 1.1 Ensembl ENCODE 9.8 -365.2 -365156 3 PRDM10 ZNF629 ZNF692 JUND PRDM1 ZIC2 ZSCAN4 POLR2A PATZ1 ZNF501 SMAD5 TRPC7 ENSG00000250284 HSALNG0045095 SPOCK1
GH05J136420 Enhancer 0.8 Ensembl 11.1 -55.1 -55055 1.2 ZNF221 PRDM10 ZNF629 ZNF692 ZIC2 POLR2A PATZ1 ZNF501 ZNF600 ZNF561 TRPC7 HNRNPA1P13 piR-49097-083
GH05J136770 Enhancer 0.7 ENCODE 11.8 -404.7 -404722 0.2 CTCF JUND FOXA1 REST RAD21 CEBPB ZXDB RCOR1 ZBTB48 SMC3 TRPC7 CTB-1I21.1 piR-52368-127 SPOCK1
GH05J136655 Enhancer 0.8 Ensembl ENCODE 10.3 -290.0 -289956 1.4 CEBPB FOS CHD2 JUN RCOR1 JUND EP300 FOSL2 GATA3 BHLHE40 TRPC7 HSALNG0045095 ENSG00000250284 SPOCK1
GH05J136771 Enhancer 0.6 Ensembl 11.8 -405.0 -404955 0.2 CTCF JUND FOXA1 RAD21 ZXDB RCOR1 SMC3 GTF2F1 FOSL2 CEBPG TRPC7 CTB-1I21.1 piR-52368-127 SPOCK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRPC7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRPC7

Top Transcription factor binding sites by QIAGEN in the TRPC7 gene promoter:
  • AML1a
  • Lhx3a
  • LHX3b
  • MIF-1
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • RORalpha1
  • STAT1alpha
  • STAT1beta

Genomic Locations for TRPC7 Gene

Genomic Locations for TRPC7 Gene
chr5:136,212,745-136,365,545
(GRCh38/hg38)
Size:
152,801 bases
Orientation:
Minus strand
chr5:135,548,999-135,732,730
(GRCh37/hg19)
Size:
183,732 bases
Orientation:
Minus strand

Genomic View for TRPC7 Gene

Genes around TRPC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC7 Gene

Proteins for TRPC7 Gene

  • Protein details for TRPC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCX4-TRPC7_HUMAN
    Recommended name:
    Short transient receptor potential channel 7
    Protein Accession:
    Q9HCX4
    Secondary Accessions:
    • A1A4Z4
    • F5H5U9
    • Q70T26
    • Q8IWP7

    Protein attributes for TRPC7 Gene

    Size:
    862 amino acids
    Molecular mass:
    99562 Da
    Quaternary structure:
    • Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1.

    Alternative splice isoforms for TRPC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPC7 Gene

Post-translational modifications for TRPC7 Gene

  • Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.
  • Glycosylation at Asn514
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRPC7 Gene

Domains & Families for TRPC7 Gene

Gene Families for TRPC7 Gene

Protein Domains for TRPC7 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature
  • Transient receptor potential family signature
  • Transient receptor ion channel II
  • Transient receptor potential channel 7 signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRPC7 Gene

GenScript: Design optimal peptide antigens:
  • TRPC7 protein (A1A4Z5_HUMAN)
  • Transient receptor potential channel 7 (Q70T24_HUMAN)
  • Transient receptor potential channel 7 (Q70T25_HUMAN)
  • Transient receptor potential channel 7 (Q70T26_HUMAN)
  • Short transient receptor potential channel 7 (Q8WWL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HCX4

UniProtKB/Swiss-Prot:

TRPC7_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily.
genes like me logo Genes that share domains with TRPC7: view

Function for TRPC7 Gene

Molecular function for TRPC7 Gene

UniProtKB/Swiss-Prot Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity). May also be activated by intracellular calcium store depletion.
GENATLAS Biochemistry:
transient receptor potential non voltage-channel 7,Drosophila store-operated channel (Soc) homolog,expressed in brain activated by calcium store depletion,component of the capacitative calcium entry,channels (homo or heterotetramer)

Phenotypes From GWAS Catalog for TRPC7 Gene

Gene Ontology (GO) - Molecular Function for TRPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding IPI 21402151
GO:0015279 store-operated calcium channel activity IBA 21873635
GO:0070679 inositol 1,4,5 trisphosphate binding IBA 21873635
genes like me logo Genes that share ontologies with TRPC7: view
genes like me logo Genes that share phenotypes with TRPC7: view

Animal Models for TRPC7 Gene

MGI Knock Outs for TRPC7:

Animal Model Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPC7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPC7 Gene

Localization for TRPC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC7 Gene

Cell membrane. Multi-pass membrane protein. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPC7 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytoskeleton 2
golgi apparatus 2
extracellular 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (1)
  • Focal adhesion sites (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005801 cis-Golgi network IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TRPC7: view

Pathways & Interactions for TRPC7 Gene

genes like me logo Genes that share pathways with TRPC7: view

Pathways by source for TRPC7 Gene

1 Qiagen pathway for TRPC7 Gene
  • Intracellular Calcium Signaling

Gene Ontology (GO) - Biological Process for TRPC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport IEA --
GO:0006828 manganese ion transport IBA 21873635
GO:0007338 single fertilization IBA 21873635
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with TRPC7: view

No data available for SIGNOR curated interactions for TRPC7 Gene

Drugs & Compounds for TRPC7 Gene

(6) Drugs for TRPC7 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amiloride Approved Pharma Channel blocker, blocker 60
2-APB Pharma Channel blocker, Pore Blocker, Antagonist, Gating inhibitor, Activator, Agonist, Potentiation IP3 receptor antagonist. Also TRP channel modulator 0
Calcium Nutra 6556
La<sup>3+</sup> Pharma Channel blocker, Pore Blocker, Antagonist, Activator 0
SKF96365 Pharma Pore Blocker, Channel blocker 0

(5) Additional Compounds for TRPC7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (5Z,8Z,11Z)-icosa-5,8,11,14-tetraenoic acid
  • DG(15:0/0:0/20:4n6)
  • Diacylglycerol(15:0/0:0/20:4)
  • DG(35:4)
  • DAG(15:0/0:0/20:4)
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with TRPC7: view

Transcripts for TRPC7 Gene

mRNA/cDNA for TRPC7 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPC7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7:

Relevant External Links for TRPC7 Gene

GeneLoc Exon Structure for
TRPC7

Expression for TRPC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPC7 Gene

This gene is overexpressed in Testis (x9.6), Pituitary (x8.4), Brain - Hypothalamus (x6.4), Kidney - Cortex (x5.6), and Brain - Putamen (basal ganglia) (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRPC7

SOURCE GeneReport for Unigene cluster for TRPC7 Gene:

Hs.591263

Evidence on tissue expression from TISSUES for TRPC7 Gene

  • Nervous system(4.5)
  • Blood(2.3)
  • Intestine(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TRPC7: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPC7 Gene

Orthologs for TRPC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRPC7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRPC7 30 31
  • 99.61 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRPC7 31
  • 95 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 95 (a)
OneToMany
-- 31
  • 94 (a)
OneToMany
-- 31
  • 93 (a)
OneToMany
-- 31
  • 86 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TRPC7 30 31
  • 94.04 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRPC7 30 31
  • 93.34 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trpc7 30
  • 90.8 (n)
Mouse
(Mus musculus)
Mammalia Trpc7 30 17 31
  • 90.53 (n)
OneToOne
Chicken
(Gallus gallus)
Aves TRPC7 30 31
  • 81.18 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRPC7 31
  • 93 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii TRPC7 (3 of 3) 31
  • 89 (a)
OneToMany
TRPC7 (2 of 3) 31
  • 84 (a)
OneToMany
TRPC7 (1 of 3) 31
  • 82 (a)
OneToMany
trpc7a 30
  • 74.92 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToMany
Species where no ortholog for TRPC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TRPC7 Gene

ENSEMBL:
Gene Tree for TRPC7 (if available)
TreeFam:
Gene Tree for TRPC7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRPC7: view image

Paralogs for TRPC7 Gene

Paralogs for TRPC7 Gene

(5) SIMAP similar genes for TRPC7 Gene using alignment to 9 proteins:

  • TRPC7_HUMAN
  • A1A4Z5_HUMAN
  • H0Y2U3_HUMAN
  • H0Y3E4_HUMAN
  • H0Y8N3_HUMAN
  • H0Y9S0_HUMAN
  • H0YAE7_HUMAN
  • Q70T24_HUMAN
  • Q70T25_HUMAN
genes like me logo Genes that share paralogs with TRPC7: view

Variants for TRPC7 Gene

Additional dbSNP identifiers (rs#s) for TRPC7 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRPC7 Gene

Variant ID Type Subtype PubMed ID
esv2661991 CNV deletion 23128226
esv2667747 CNV deletion 23128226
esv3307181 CNV mobile element insertion 20981092
esv3395342 CNV insertion 20981092
esv3606877 CNV loss 21293372
esv3606878 CNV loss 21293372
esv3606879 CNV loss 21293372
nsv1152087 CNV duplication 26484159
nsv508381 CNV deletion 20534489

Variation tolerance for TRPC7 Gene

Residual Variation Intolerance Score: 4.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPC7 Gene

Human Gene Mutation Database (HGMD)
TRPC7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPC7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRPC7 Gene

Disorders for TRPC7 Gene

Additional Disease Information for TRPC7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for TRPC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRPC7 Gene

Publications for TRPC7 Gene

  1. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. (PMID: 11805119) Riccio A … Pangalos MN (The Journal of biological chemistry 2002) 2 3 23
  2. Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Iα. (PMID: 21402151) Yuasa K … Tsuji A (Cellular signalling 2011) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. (PMID: 19812035) Miyagi K … Mori Y (The Journal of biological chemistry 2009) 3 23
  5. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert TA … Walter MJ (PloS one 2009) 3 41

Products for TRPC7 Gene

  • Signalway Proteins for TRPC7

Sources for TRPC7 Gene