Aliases for TRPC6 Gene
External Ids for TRPC6 Gene
Previous HGNC Symbols for TRPC6 Gene
Previous GeneCards Identifiers for TRPC6 Gene
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
GeneCards Summary for TRPC6 Gene
TRPC6 (Transient Receptor Potential Cation Channel Subfamily C Member 6) is a Protein Coding gene. Diseases associated with TRPC6 include Focal Segmental Glomerulosclerosis 2 and Genetic Steroid-Resistant Nephrotic Syndrome. Among its related pathways are Signaling by GPCR and cGMP-PKG signaling pathway. Gene Ontology (GO) annotations related to this gene include binding and calcium channel activity. An important paralog of this gene is TRPC7.
UniProtKB/Swiss-Prot Summary for TRPC6 Gene
Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.