This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. ... See more...

Aliases for TRPC5 Gene

Aliases for TRPC5 Gene

  • Transient Receptor Potential Cation Channel Subfamily C Member 5 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 159 2 3
  • Short Transient Receptor Potential Channel 5 3 4
  • Transient Receptor Protein 5 3 4
  • PPP1R159 2 3
  • TRP-5 3 4
  • HTRP5 3 4
  • TRP5 3 4
  • Transient Receptor Potential Cation Channel, Subfamily C, Member 5 2
  • Transient Receptor Potential Channel 5 3
  • HTRP-5 4
  • TRPC5 5
  • TrpC5 4

External Ids for TRPC5 Gene

Previous GeneCards Identifiers for TRPC5 Gene

  • GC0XM106320
  • GC0XM108164
  • GC0XM109042
  • GC0XM109781
  • GC0XM110823
  • GC0XM110904
  • GC0XM111017
  • GC0XM100639

Summaries for TRPC5 Gene

Entrez Gene Summary for TRPC5 Gene

  • This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]

GeneCards Summary for TRPC5 Gene

TRPC5 (Transient Receptor Potential Cation Channel Subfamily C Member 5) is a Protein Coding gene. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis. Among its related pathways are Netrin-1 signaling and Axon guidance. Gene Ontology (GO) annotations related to this gene include ion channel activity and store-operated calcium channel activity. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot Summary for TRPC5 Gene

  • Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.

Gene Wiki entry for TRPC5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRPC5 Gene

Genomics for TRPC5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRPC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ112081 Promoter 0.7 Ensembl 600.7 -0.4 -358 1.8 SP1 EZH2 YY1 RAD21 HNF4A RXRA CTCF TRPC5 RTL4 CAPN6 piR-39891-088 LHFPL1
GH0XJ112051 Enhancer 0.3 Ensembl 12.5 +31.3 31343 1.6 CEBPB RF00017-8621 TRPC5 TRPC5OS
GH0XJ111944 Enhancer 0.3 FANTOM5 1.9 +138.4 138396 0.3 ATF2 TRPC5 RTL4 ENSG00000271421 lnc-TRPC5OS-6 piR-55194-456 TRPC5OS
GH0XJ112058 Enhancer 0.3 ENCODE 0.4 +24.5 24475 0.2 FOS RF00017-8621 TRPC5 TRPC5OS
GH0XJ111914 Enhancer 0.6 Ensembl ENCODE 0.1 +168.3 168308 0.7 SCRT2 CEBPB SPI1 FEZF1 ZBTB21 TRPC5OS ENSG00000271421 lnc-TRPC5OS-6 TRPC5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRPC5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRPC5

Top Transcription factor binding sites by QIAGEN in the TRPC5 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • HNF-3beta
  • NF-Y
  • NF-YA
  • NF-YB
  • RREB-1
  • Sp1

Genomic Locations for TRPC5 Gene

Genomic Locations for TRPC5 Gene
chrX:111,774,314-112,082,943
(GRCh38/hg38)
Size:
308,630 bases
Orientation:
Minus strand
chrX:111,017,542-111,326,004
(GRCh37/hg19)
Size:
308,463 bases
Orientation:
Minus strand

Genomic View for TRPC5 Gene

Genes around TRPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC5 Gene

Proteins for TRPC5 Gene

  • Protein details for TRPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL62-TRPC5_HUMAN
    Recommended name:
    Short transient receptor potential channel 5
    Protein Accession:
    Q9UL62
    Secondary Accessions:
    • B2RP53
    • O75233
    • Q5JXY8
    • Q9Y514

    Protein attributes for TRPC5 Gene

    Size:
    973 amino acids
    Molecular mass:
    111412 Da
    Quaternary structure:
    • Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4. Interacts with NHERF (By similarity). Interacts with MX1 and RNF24. Interacts (via C-terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1 repeat).

neXtProt entry for TRPC5 Gene

Post-translational modifications for TRPC5 Gene

  • Glycosylation at Asn461
  • Modification sites at PhosphoSitePlus

Other Protein References for TRPC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for TRPC5
  • Santa Cruz Biotechnology (SCBT) Antibodies for TRPC5

No data available for DME Specific Peptides for TRPC5 Gene

Domains & Families for TRPC5 Gene

Gene Families for TRPC5 Gene

Protein Domains for TRPC5 Gene

InterPro:
Blocks:
  • Transient receptor potential family signature
  • Transient receptor ion channel II
  • Transient receptor potential channel 5 signature
ProtoNet:

Suggested Antigen Peptide Sequences for TRPC5 Gene

GenScript: Design optimal peptide antigens:
  • Transient receptor protein 5 (TRPC5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UL62

UniProtKB/Swiss-Prot:

TRPC5_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.
genes like me logo Genes that share domains with TRPC5: view

Function for TRPC5 Gene

Molecular function for TRPC5 Gene

UniProtKB/Swiss-Prot Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion.
UniProtKB/Swiss-Prot EnzymeRegulation:
Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane.
GENATLAS Biochemistry:
transient receptor potential non voltage-channel 5,Drosophila store-operated calcium channel (Soc) homolog,ubiquitous but predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion component of the capacitative calcium entry channels (homo or heterotetramer),involved in mental retardation

Phenotypes From GWAS Catalog for TRPC5 Gene

Gene Ontology (GO) - Molecular Function for TRPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005216 ion channel activity IEA --
GO:0005262 calcium channel activity IDA 20164195
GO:0005515 protein binding IPI 20164195
GO:0015279 store-operated calcium channel activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with TRPC5: view
genes like me logo Genes that share phenotypes with TRPC5: view

Animal Models for TRPC5 Gene

MGI Knock Outs for TRPC5:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPC5

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPC5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPC5 Gene

Localization for TRPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPC5 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TRPC5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRPC5 Gene

Pathways & Interactions for TRPC5 Gene

genes like me logo Genes that share pathways with TRPC5: view

Pathways by source for TRPC5 Gene

2 Qiagen pathways for TRPC5 Gene
  • Breast Cancer Regulation by Stathmin1
  • Intracellular Calcium Signaling

Gene Ontology (GO) - Biological Process for TRPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport TAS 10493832
GO:0006828 manganese ion transport IBA 21873635
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007399 nervous system development TAS 10493832
genes like me logo Genes that share ontologies with TRPC5: view

No data available for SIGNOR curated interactions for TRPC5 Gene

Drugs & Compounds for TRPC5 Gene

(19) Drugs for TRPC5 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chlorpromazine Approved, Investigational, Vet_approved Pharma Antagonist, Inverse agonist, Channel blocker, antagonist 25
Flufenamic acid Approved Pharma Channel blocker, Inhibitor, Pore Blocker, Antagonist Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6 0
Progesterone Approved, Vet_approved Pharma Activator, Full agonist, Agonist, Pore Blocker, Inhibition, inhibitor Endogenous progesterone receptor agonist 755
Rosiglitazone Approved, Investigational Pharma Agonist, Full agonist, Activator, Activation, Channel blocker, agonist Potent PPARγ agonist, Potent and selective PPARgamma agonist; antidiabetic agent. 226
Daidzein Experimental Pharma 13

(6) Additional Compounds for TRPC5 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7,4'-dihydroxyisoflavone
Agonist, Activator
genes like me logo Genes that share compounds with TRPC5: view

Transcripts for TRPC5 Gene

mRNA/cDNA for TRPC5 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPC5

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC5 Gene

No ASD Table

Relevant External Links for TRPC5 Gene

GeneLoc Exon Structure for
TRPC5

Expression for TRPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for TRPC5 Gene

This gene is overexpressed in Brain - Hypothalamus (x7.4), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Frontal Cortex (BA9) (x6.1), and Brain - Cortex (x5.7).

Protein differential expression in normal tissues from HIPED for TRPC5 Gene

This gene is overexpressed in Fetal heart (27.3), Retina (18.5), and Frontal cortex (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRPC5 Gene



Protein tissue co-expression partners for TRPC5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRPC5

SOURCE GeneReport for Unigene cluster for TRPC5 Gene:

Hs.657709

mRNA Expression by UniProt/SwissProt for TRPC5 Gene:

Q9UL62-TRPC5_HUMAN
Tissue specificity: Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole.

Evidence on tissue expression from TISSUES for TRPC5 Gene

  • Nervous system(4.5)
  • Heart(2.4)
  • Kidney(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with TRPC5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPC5 Gene

Orthologs for TRPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPC5 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 97 (a)
OneToMany
-- 31
  • 66 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia TRPC5 30 31
  • 93.9 (n)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia TRPC5 30 31
  • 93.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRPC5 30 31
  • 93.66 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trpc5 30
  • 91.3 (n)
Mouse
(Mus musculus)
Mammalia Trpc5 30 17 31
  • 90.41 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TRPC5 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRPC5 30 31
  • 79 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRPC5 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trpc5 30
  • 75.72 (n)
Zebrafish
(Danio rerio)
Actinopterygii trpc5a 31
  • 71 (a)
OneToMany
LOC555897 30
  • 69.78 (n)
trpc5b 31
  • 56 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta trpgamma 31 32
  • 37 (a)
ManyToMany
trpl 31 32
  • 34 (a)
ManyToMany
trp 31 32
  • 30 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea trp-2 31
  • 41 (a)
OneToMany
trp-1 32
  • 39 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 31 (a)
ManyToMany
Species where no ortholog for TRPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRPC5 Gene

ENSEMBL:
Gene Tree for TRPC5 (if available)
TreeFam:
Gene Tree for TRPC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRPC5: view image

Paralogs for TRPC5 Gene

Paralogs for TRPC5 Gene

(6) SIMAP similar genes for TRPC5 Gene using alignment to 1 proteins:

  • TRPC5_HUMAN
genes like me logo Genes that share paralogs with TRPC5: view

Variants for TRPC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRPC5 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
734920 Benign: not provided 111,912,807(-) G/A SYNONYMOUS_VARIANT
781557 Benign: not provided 111,952,382(-) C/T SYNONYMOUS_VARIANT
785707 Benign: not provided 111,835,026(-) G/A SYNONYMOUS_VARIANT
807805 Uncertain Significance: not provided 111,776,834(-) A/G SYNONYMOUS_VARIANT
807806 Uncertain Significance: not provided 111,952,294(-) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TRPC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRPC5 Gene

Variant ID Type Subtype PubMed ID
esv2675427 CNV deletion 23128226
esv3303927 CNV mobile element insertion 20981092
esv3342357 CNV insertion 20981092
esv3361732 OTHER inversion 20981092
esv3429512 CNV insertion 20981092
esv3559183 CNV deletion 23714750
nsv520386 CNV gain 19592680
nsv526892 CNV gain 19592680
nsv7039 CNV deletion 18451855
nsv7040 CNV deletion 18451855

Variation tolerance for TRPC5 Gene

Residual Variation Intolerance Score: 9.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPC5 Gene

Human Gene Mutation Database (HGMD)
TRPC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPC5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC5 Gene

Disorders for TRPC5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TRPC5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypertrophic pyloric stenosis
  • congenital hypertrophic pyloric stenosis
pyloric stenosis
hypertension, essential
  • eht
giant cell glioblastoma
  • monstrocellular sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search TRPC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRPC5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPC5 Gene

Publications for TRPC5 Gene

  1. Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel. (PMID: 10493832) Sossey-Alaoui K … Srivastava AK (Genomics 1999) 2 3 4 23
  2. The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5. (PMID: 20164195) Miehe S … Strübing C (The Journal of biological chemistry 2010) 3 4 23
  3. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N … Bergen AW (PloS one 2009) 3 41
  4. Infantile hypertrophic pyloric stenosis: evaluation of three positional candidate genes, TRPC1, TRPC5 and TRPC6, by association analysis and re-sequencing. (PMID: 19701773) Everett KV … Chung EM (Human genetics 2009) 3 41
  5. Molecular determinant of sensing extracellular pH in classical transient receptor potential channel 5. (PMID: 17981154) Kim MJ … So I (Biochemical and biophysical research communications 2008) 3 23

Products for TRPC5 Gene

Sources for TRPC5 Gene