Aliases for TRPC5 Gene
External Ids for TRPC5 Gene
Previous GeneCards Identifiers for TRPC5 Gene
This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]
GeneCards Summary for TRPC5 Gene
TRPC5 (Transient Receptor Potential Cation Channel Subfamily C Member 5) is a Protein Coding gene. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis. Among its related pathways are Netrin-1 signaling and Ion channel transport. Gene Ontology (GO) annotations related to this gene include ion channel activity and store-operated calcium channel activity. An important paralog of this gene is TRPC4.
UniProtKB/Swiss-Prot Summary for TRPC5 Gene
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).