Aliases for TRPC4 Gene
External Ids for TRPC4 Gene
Previous GeneCards Identifiers for TRPC4 Gene
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for TRPC4 Gene
TRPC4 (Transient Receptor Potential Cation Channel Subfamily C Member 4) is a Protein Coding gene. Diseases associated with TRPC4 include Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques and Photosensitive Epilepsy. Among its related pathways are Netrin-1 signaling and Ion channel transport. Gene Ontology (GO) annotations related to this gene include ion channel activity and calcium channel activity. An important paralog of this gene is TRPC5.
UniProtKB/Swiss-Prot Summary for TRPC4 Gene
Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7).