Aliases for TRPC3 Gene
External Ids for TRPC3 Gene
Previous GeneCards Identifiers for TRPC3 Gene
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for TRPC3 Gene
TRPC3 (Transient Receptor Potential Cation Channel Subfamily C Member 3) is a Protein Coding gene. Diseases associated with TRPC3 include Spinocerebellar Ataxia 41 and Sialolithiasis. Among its related pathways are Effects of PIP2 hydrolysis and Netrin-1 signaling. Gene Ontology (GO) annotations related to this gene include binding and calcium channel activity. An important paralog of this gene is TRPC7.
UniProtKB/Swiss-Prot for TRPC3 Gene
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.