The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isofo... See more...

Aliases for TRPC1 Gene

Aliases for TRPC1 Gene

  • Transient Receptor Potential Cation Channel Subfamily C Member 1 2 3 5
  • Short Transient Receptor Potential Channel 1 3 4
  • Transient Receptor Protein 1 3 4
  • HTRP-1 2 3
  • TRP-1 3 4
  • TRP1 3 4
  • Transient Receptor Potential Cation Channel, Subfamily C, Member 1 2
  • Capacitative Calcium Channel Protein Trp1 3
  • Transient Receptor Potential Canonical 1 3
  • TRPC1 5
  • TrpC1 4

External Ids for TRPC1 Gene

Previous GeneCards Identifiers for TRPC1 Gene

  • GC03P139404
  • GC03P143271
  • GC03P143724
  • GC03P143764
  • GC03P143925
  • GC03P142440
  • GC03P139815

Summaries for TRPC1 Gene

Entrez Gene Summary for TRPC1 Gene

  • The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TRPC1 Gene

TRPC1 (Transient Receptor Potential Cation Channel Subfamily C Member 1) is a Protein Coding gene. Diseases associated with TRPC1 include Hypertrophic Pyloric Stenosis and Lymph Node Carcinoma. Among its related pathways are Netrin-1 signaling and Cell-type Dependent Selectivity of CCK2R Signaling. Gene Ontology (GO) annotations related to this gene include ion channel activity and calcium channel activity. An important paralog of this gene is TRPC4.

UniProtKB/Swiss-Prot Summary for TRPC1 Gene

  • Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Gene Wiki entry for TRPC1 Gene

Additional gene information for TRPC1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRPC1 Gene

Genomics for TRPC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRPC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J142723 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 606.1 +0.7 746 2.8 CREB1 GATAD2A ZNF629 IKZF1 KDM1A ZNF692 BACH1 JUND LARP7 RBFOX2 TRPC1 ENSG00000287045 PLS1 RNA5SP143 RNF7 RF00066-133 RNU7-47P PCOLCE2
GH03J142222 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.5 -499.7 -499661 4.5 CTCF HNRNPL PRDM10 ZNF692 POLR2A RCOR2 ZNF7 BACH1 TARDBP JUND GK5 lnc-ATP1B3-4 lnc-TFDP2-7 U2SURP PBX2P1 XRN1 ATR TRPC1 RASA2 piR-42694-118
GH03J141803 Enhancer 1.1 Ensembl dbSUPER 11.9 -918.9 -918933 0.2 RNF2 LEF1 IKZF1 DDX20 MTA2 ZSCAN4 PKNOX1 MTA1 NR2C1 ZNF24 XRN1 ATR TRPC1 RASA2 YWHAQP6 piR-33905-057 piR-30847 GRK7 ENSG00000285558 ATP1B3
GH03J142316 Enhancer 0.9 ENCODE 12.5 -407.9 -407930 0.1 GATAD2A ATF7 ZNF629 LEF1 RCOR2 JUND DDX20 RXRB MTA1 DPF2 TRPC1 U2SURP RNU1-100P MF281455 piR-31307 GK5 XRN1
GH03J141913 Enhancer 0.7 ENCODE 12.5 -810.6 -810640 0.2 CTCF KDM1A ZNF143 REST RAD21 ZNF24 CBX3 HMBOX1 USF2 MTA3 ATP1B3 TRPC1 RNF7 GRK7 RNU6-425P ATP1B3-AS1 RF00026-739 RNU6-509P TFDP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRPC1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRPC1

Top Transcription factor binding sites by QIAGEN in the TRPC1 gene promoter:
  • AP-2rep
  • C/EBPalpha
  • CHOP-10
  • CUTL1
  • Evi-1
  • FOXO4
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b

Genomic Locations for TRPC1 Gene

Genomic Locations for TRPC1 Gene
chr3:142,724,034-142,807,888
(GRCh38/hg38)
Size:
83,855 bases
Orientation:
Plus strand
chr3:142,442,916-142,526,730
(GRCh37/hg19)
Size:
83,815 bases
Orientation:
Plus strand

Genomic View for TRPC1 Gene

Genes around TRPC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPC1 Gene

Proteins for TRPC1 Gene

  • Protein details for TRPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48995-TRPC1_HUMAN
    Recommended name:
    Short transient receptor potential channel 1
    Protein Accession:
    P48995
    Secondary Accessions:
    • Q14CE4

    Protein attributes for TRPC1 Gene

    Size:
    793 amino acids
    Molecular mass:
    91212 Da
    Quaternary structure:
    • Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.

    Alternative splice isoforms for TRPC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPC1 Gene

Post-translational modifications for TRPC1 Gene

  • Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRPC1 Gene

No data available for DME Specific Peptides for TRPC1 Gene

Domains & Families for TRPC1 Gene

Gene Families for TRPC1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Protein Domains for TRPC1 Gene

InterPro:
Blocks:
  • Transient receptor potential family signature
  • Transient receptor potential channel 1 signature
  • Transient receptor ion channel II
ProtoNet:

Suggested Antigen Peptide Sequences for TRPC1 Gene

GenScript: Design optimal peptide antigens:
  • Transient receptor potential cation channel, subfamily C, member 1, short isoform (A7VJS2_HUMAN)
  • Transient receptor protein 1 (TRPC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48995

UniProtKB/Swiss-Prot:

TRPC1_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
genes like me logo Genes that share domains with TRPC1: view

Function for TRPC1 Gene

Molecular function for TRPC1 Gene

UniProtKB/Swiss-Prot Function:
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
GENATLAS Biochemistry:
transient receptor potential non voltage-channel 1,Drosophila store-operated channel (Soc) homolog,ubiquitous but predominantly expressed in fetal brain,adult heart,brain,testis,ovaries,activated by calcium store depletion component of the capacitative calcium entry channels (homo or heterotetramer)

Phenotypes From GWAS Catalog for TRPC1 Gene

Gene Ontology (GO) - Molecular Function for TRPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 18068335
GO:0005216 ion channel activity IEA --
GO:0005261 cation channel activity EXP 18995841
GO:0005262 calcium channel activity TAS 8646775
GO:0005515 protein binding IPI 10097141
genes like me logo Genes that share ontologies with TRPC1: view
genes like me logo Genes that share phenotypes with TRPC1: view

Animal Models for TRPC1 Gene

MGI Knock Outs for TRPC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRPC1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPC1 Gene

Localization for TRPC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPC1 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPC1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS,IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRPC1: view

Pathways & Interactions for TRPC1 Gene

genes like me logo Genes that share pathways with TRPC1: view

Pathways by source for TRPC1 Gene

Gene Ontology (GO) - Biological Process for TRPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport TAS 8646775
GO:0006828 manganese ion transport IBA 21873635
GO:0042438 melanin biosynthetic process IDA 8126111
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA 19052258
genes like me logo Genes that share ontologies with TRPC1: view

No data available for SIGNOR curated interactions for TRPC1 Gene

Drugs & Compounds for TRPC1 Gene

(18) Drugs for TRPC1 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-APB Pharma Channel blocker, Pore Blocker, Antagonist, Gating inhibitor, Activator, Agonist, Potentiation IP3 receptor antagonist. Also TRP channel modulator 0
Gd<sup>3+</sup> Pharma Channel blocker, Pore Blocker, Antagonist, Activator 0
GsMTx-4 Pharma Channel blocker 0
La<sup>3+</sup> Pharma Channel blocker, Pore Blocker, Antagonist, Activator 0
SKF96365 Pharma Pore Blocker, Channel blocker 0

(4) Additional Compounds for TRPC1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for TRPC1 Gene

Compound Action Cas Number
Optovin 348575-88-2
SKF 96365 hydrochloride SOCE inhibitor 130495-35-1
WS 3 39711-79-0
genes like me logo Genes that share compounds with TRPC1: view

Drug Products

Transcripts for TRPC1 Gene

mRNA/cDNA for TRPC1 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPC1

Alternative Splicing Database (ASD) splice patterns (SP) for TRPC1 Gene

No ASD Table

Relevant External Links for TRPC1 Gene

GeneLoc Exon Structure for
TRPC1

Expression for TRPC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPC1 Gene

Protein differential expression in normal tissues from HIPED for TRPC1 Gene

This gene is overexpressed in Lung (43.3) and Testis (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRPC1 Gene



Protein tissue co-expression partners for TRPC1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRPC1

SOURCE GeneReport for Unigene cluster for TRPC1 Gene:

Hs.250687

mRNA Expression by UniProt/SwissProt for TRPC1 Gene:

P48995-TRPC1_HUMAN
Tissue specificity: Seems to be ubiquitous.

Evidence on tissue expression from TISSUES for TRPC1 Gene

  • Nervous system(4.7)
  • Muscle(3.1)
  • Intestine(2.9)
  • Heart(2.9)
  • Pancreas(2.9)
  • Kidney(2.8)
  • Bone marrow(2.7)
  • Lung(2.6)
  • Adrenal gland(2.6)
  • Stomach(2.5)
  • Skin(2.5)
  • Gall bladder(2.2)
  • Blood(2.2)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with TRPC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPC1 Gene

Orthologs for TRPC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPC1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRPC1 30 31
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRPC1 30 31
  • 95.42 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TRPC1 31
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRPC1 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia TRPC1 30 31
  • 94.12 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trpc1 30 17 31
  • 91.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trpc1 30
  • 90.21 (n)
Chicken
(Gallus gallus)
Aves TRPC1 30 31
  • 83.4 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRPC1 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trpc1 30
  • 77.92 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.470 30
Zebrafish
(Danio rerio)
Actinopterygii trpc1 30 31
  • 72.63 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta trpgamma 31
  • 28 (a)
ManyToMany
trpl 31
  • 25 (a)
ManyToMany
trp 31
  • 21 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea trp-1 32
  • 35 (a)
trp-2 31
  • 33 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 23 (a)
ManyToMany
Species where no ortholog for TRPC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRPC1 Gene

ENSEMBL:
Gene Tree for TRPC1 (if available)
TreeFam:
Gene Tree for TRPC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRPC1: view image

Paralogs for TRPC1 Gene

Paralogs for TRPC1 Gene

(4) SIMAP similar genes for TRPC1 Gene using alignment to 3 proteins:

  • TRPC1_HUMAN
  • A7VJS2_HUMAN
  • H7C508_HUMAN
genes like me logo Genes that share paralogs with TRPC1: view

Variants for TRPC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRPC1 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
rs193920786 Uncertain Significance: Malignant tumor of prostate 142,784,713(+) C/T NONSENSE

Additional dbSNP identifiers (rs#s) for TRPC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRPC1 Gene

Variant ID Type Subtype PubMed ID
dgv300n21 CNV gain 19592680
esv3303979 CNV mobile element insertion 20981092
esv3310329 CNV mobile element insertion 20981092
esv3337166 CNV insertion 20981092
esv3411265 CNV insertion 20981092
esv3569029 CNV loss 25503493
esv3598008 CNV loss 21293372
nsv1000631 CNV gain 25217958
nsv591920 CNV loss 21841781
nsv820119 CNV loss 19587683

Variation tolerance for TRPC1 Gene

Residual Variation Intolerance Score: 9.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPC1 Gene

Disorders for TRPC1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for TRPC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypertrophic pyloric stenosis
  • congenital hypertrophic pyloric stenosis
lymph node carcinoma
  • lymph node cancer
pyloric stenosis
darier-white disease
  • dar
mucolipidosis iv
  • ml4
- elite association - COSMIC cancer census association via MalaCards
Search TRPC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRPC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TRPC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPC1 Gene

Publications for TRPC1 Gene

  1. TRPC1, a human homolog of a Drosophila store-operated channel. (PMID: 7568191) Wes PD … Montell C (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 23
  2. Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. (PMID: 15016832) Ahmmed GU … Malik AB (The Journal of biological chemistry 2004) 3 4 23
  3. TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells. (PMID: 11139478) Xu SZ … Beech DJ (Circulation research 2001) 3 4 23
  4. Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. (PMID: 10766822) Lockwich TP … Ambudkar IS (The Journal of biological chemistry 2000) 3 4 23
  5. Expression and association of TRPC subtypes with Orai1 and STIM1 in human parathyroid. (PMID: 20194530) Lu M … Forsberg L (Journal of molecular endocrinology 2010) 3 23

Products for TRPC1 Gene

Sources for TRPC1 Gene