The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008] See more...

Aliases for TRPA1 Gene

Aliases for TRPA1 Gene

  • Transient Receptor Potential Cation Channel Subfamily A Member 1 2 3 4 5
  • Ankyrin-Like With Transmembrane Domains 1 2 3
  • Transformation-Sensitive Protein P120 3 4
  • Wasabi Receptor 3 4
  • ANKTM1 3 4
  • Transient Receptor Potential Cation Channel, Subfamily A, Member 1 2
  • Ankyrin-Like With Transmembrane Domains Protein 1 4
  • FEPS1 3
  • TRPA1 5
  • FEPS 3

External Ids for TRPA1 Gene

Previous HGNC Symbols for TRPA1 Gene

  • ANKTM1

Previous GeneCards Identifiers for TRPA1 Gene

  • GC08M072983
  • GC08M073096
  • GC08M068428
  • GC08M072932

Summaries for TRPA1 Gene

Entrez Gene Summary for TRPA1 Gene

  • The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRPA1 Gene

TRPA1 (Transient Receptor Potential Cation Channel Subfamily A Member 1) is a Protein Coding gene. Diseases associated with TRPA1 include Episodic Pain Syndrome, Familial, 1 and Familial Episodic Pain Syndrome. Among its related pathways are Ion channel transport and TRP channels. Gene Ontology (GO) annotations related to this gene include ion channel activity and channel activity.

UniProtKB/Swiss-Prot Summary for TRPA1 Gene

  • Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:25855297). Shows 8-fold preference for divalent over monovalent cations (PubMed:31447178). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:27241698, PubMed:30878828, PubMed:20547126). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).

Tocris Summary for TRPA1 Gene

  • The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer.

Gene Wiki entry for TRPA1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRPA1 Gene

Genomics for TRPA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRPA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J072075 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 250.4 +19.6 19584 1.4 ZIC2 SKIL SMARCA4 EP400 ZEB2 TAF1 SNIP1 GLIS1 ZBTB40 L3MBTL2 TRPA1 MSC-AS1 lnc-MSC-4 lnc-KCNB2-5 MSC
GH08J072095 Enhancer 0.9 FANTOM5 Ensembl 250.7 -1.0 -1016 0.6 NCOR1 ZNF592 NFATC3 TAL1 RELA MYNN SMARCA4 HDAC2 ZBTB33 CAVIN1 TRPA1 ENSG00000200191 MN298508 lnc-KCNB2-5 MSC-AS1 KCNB2
GH08J072094 Enhancer 0.4 Ensembl 250.7 +0.7 684 0.8 ZNF316 NFE2L2 FOS TRPA1 lnc-MSC-4 lnc-KCNB2-5 MSC MSC-AS1
GH08J072106 Enhancer 1 Ensembl ENCODE 0.4 -12.9 -12868 2.5 NCOR1 ZNF592 NFIC CEBPB HES1 ZNF639 ARNT IRF2 EP300 FOXA2 MN298508 MN298509 TRPA1 lnc-KCNB2-5 MSC-AS1 KCNB2
GH08J072067 Enhancer 0.6 Ensembl ENCODE 0.3 +27.4 27382 1 MEIS2 ZNF24 PKNOX1 ENSG00000200191 lnc-MSC-4 TRPA1 lnc-KCNB2-5 MSC MSC-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRPA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRPA1

Top Transcription factor binding sites by QIAGEN in the TRPA1 gene promoter:
  • ER-alpha
  • FOXI1
  • HFH-3
  • ITF-2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Tal-1beta

Genomic Locations for TRPA1 Gene

Latest Assembly
chr8:72,019,917-72,094,885
(GRCh38/hg38)
Size:
74,969 bases
Orientation:
Minus strand

Previous Assembly
chr8:72,933,485-72,987,819
(GRCh37/hg19 by Entrez Gene)
Size:
54,335 bases
Orientation:
Minus strand

chr8:72,932,152-72,987,852
(GRCh37/hg19 by Ensembl)
Size:
55,701 bases
Orientation:
Minus strand

Genomic View for TRPA1 Gene

Genes around TRPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPA1 Gene

Proteins for TRPA1 Gene

  • Protein details for TRPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75762-TRPA1_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily A member 1
    Protein Accession:
    O75762
    Secondary Accessions:
    • A6NIN6

    Protein attributes for TRPA1 Gene

    Size:
    1119 amino acids
    Molecular mass:
    127501 Da
    Quaternary structure:
    • Homotetramer (PubMed:25389312, PubMed:25855297). Interacts with TMEM100 (By similarity). Interacts with EGLN1 (By similarity). Interacts with the scorpion wasabi receptor toxin at the same site that electrophiles but in a non-covalent manner (PubMed:31447178).

    Three dimensional structures from OCA and Proteopedia for TRPA1 Gene

neXtProt entry for TRPA1 Gene

Post-translational modifications for TRPA1 Gene

  • TRPA1 activation by electrophiles occurs though covalent modification of specific cysteine residues in the N-terminal cytoplasmic domain (PubMed:25389312).
  • Hydroxylation is required for TRPA1 activity inhibition in normoxia. In hypoxia, the decrease in oxygene concentration diminishes the activity of the hydroxylase EGLN1, thus relieving TRPA1 from inhibition and ultimately leading to channel activation.
  • Oxidation of Cys-633 and Cys-856 in hyperoxia may override the hydroxylase EGLN1-mediated inhibition, causing TRPA1 activation.
  • Glycosylation at Asn747 and Asn753
  • Modification sites at PhosphoSitePlus

Other Protein References for TRPA1 Gene

No data available for DME Specific Peptides for TRPA1 Gene

Domains & Families for TRPA1 Gene

Gene Families for TRPA1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • Predicted membrane proteins
  • Transporters
  • Voltage-gated ion channels

Protein Domains for TRPA1 Gene

InterPro:
Blocks:
  • Ankyrin repeat signature

Suggested Antigen Peptide Sequences for TRPA1 Gene

GenScript: Design optimal peptide antigens:
  • Transformation-sensitive protein p120 (TRPA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75762

UniProtKB/Swiss-Prot:

TRPA1_HUMAN :
  • C-terminal helices from the four subunits associate to form atypical coiled coil structure; this region is probably involved in binding the inositol polyphosphates that are required for optimal channel activity (in vitro).
  • Belongs to the transient receptor (TC 1.A.4) family.
Domain:
  • C-terminal helices from the four subunits associate to form atypical coiled coil structure; this region is probably involved in binding the inositol polyphosphates that are required for optimal channel activity (in vitro).
  • The ANK repeat domain consists of a convex stem structure formed by five ANK repeats and 11 additional ANK repeats that form a crescent-shaped structure that surrounds the protein core.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family.
genes like me logo Genes that share domains with TRPA1: view

Function for TRPA1 Gene

Molecular function for TRPA1 Gene

UniProtKB/Swiss-Prot Function:
Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function (PubMed:21873995, PubMed:23199233, PubMed:25389312, PubMed:25855297). Shows 8-fold preference for divalent over monovalent cations (PubMed:31447178). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:27241698, PubMed:30878828, PubMed:20547126). Acts also as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). Is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
A cytosolic factor (probably pyrophosphate, polytriphosphate, polyP4, polyP25, polyP45, and/or polyP65) is necessary for TRPA1 activation by irritants (PubMed:17567811). Such factor acts by keeping TRPA1 in a agonist-sensitive state (PubMed:17567811). Inhibited by the potent blocker of TRPV channels ruthenium red, A-967079, AP-18, HC-030031, and aryl sulfonamide derivative (S)-N-(4-chlorobenzyl)-1-((4-fluorophenyl)sulfonyl)pyrrolidine-2-carboxamide (ASD) (PubMed:17567811, PubMed:21873995, PubMed:21402443, PubMed:30878828, PubMed:20547126). Non-covalently activated by the scorpion wasabi receptor toxin (PubMed:31447178). Activated by benzyl isothiocyanate (BITC), iodoacetamide, sulfhydryl reactive agent MTSEA, N-methyl maleimide (NMM), N-ethylmaleimide (NEM), and 2-aminoethyldiphenylborinate (2-APB) (PubMed:17164327, PubMed:17567811, PubMed:21873995, PubMed:27241698). Also activated by hyperoxia (PubMed:21873995).

Phenotypes From GWAS Catalog for TRPA1 Gene

Gene Ontology (GO) - Molecular Function for TRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005262 calcium channel activity IEA --
GO:0005515 protein binding IEA --
GO:0015267 channel activity IEA,TAS 10066796
GO:0015278 calcium-release channel activity IMP 25855297
genes like me logo Genes that share ontologies with TRPA1: view
genes like me logo Genes that share phenotypes with TRPA1: view

Human Phenotype Ontology for TRPA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRPA1 Gene

MGI Knock Outs for TRPA1:

Animal Models for research

  • Taconic Biosciences Mouse Models for TRPA1

miRNA for TRPA1 Gene

miRTarBase miRNAs that target TRPA1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPA1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TRPA1 Gene

Localization for TRPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPA1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPA1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IMP 20547126
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032421 stereocilium bundle IEA --
genes like me logo Genes that share ontologies with TRPA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRPA1 Gene

Pathways & Interactions for TRPA1 Gene

genes like me logo Genes that share pathways with TRPA1: view

Pathways by source for TRPA1 Gene

Gene Ontology (GO) - Biological Process for TRPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS 10066796
GO:0006816 calcium ion transport IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0009409 response to cold IEA --
GO:0010033 response to organic substance IMP 20547126
genes like me logo Genes that share ontologies with TRPA1: view

No data available for SIGNOR curated interactions for TRPA1 Gene

Drugs & Compounds for TRPA1 Gene

(92) Drugs for TRPA1 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Menthol Approved Pharma Activator, Activation, Partial agonist, Target, inducer 165
Apomorphine Approved, Investigational Pharma Activator, Activation, agonist 49
Auranofin Approved, Investigational Pharma Activator, Activation, inhibitor Thioredoxin reductase inhibitor; induces MPT 12
Nicotine Approved Pharma Activator, Activation, antagonist 1617
Thymol Approved Pharma Activator, Activation 12

(5) Additional Compounds for TRPA1 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-pentenal
  • FEMA 3218
Activator, Agonist 764-39-6
chembridge-5861528
Gating inhibitor, Inhibition
formalin
Activator, Activation
ASP 7663
1190217-35-6

(4) Tocris Compounds for TRPA1 Gene

Compound Action Cas Number
ASP 7663 Selective TRPA1 activator 1190217-35-6
Icilin Activates a novel cold receptor. Cooling agent 36945-98-9
Optovin Reversible photoactive TRPA1 activator 348575-88-2
Polygodial TRPA1 channel activator; analgesic and antifungal 6754-20-7

(33) ApexBio Compounds for TRPA1 Gene

Compound Action Cas Number
5'-Iodoresiniferatoxin 535974-91-5
6'-Iodoresiniferatoxin 335151-55-8
9-Phenanthrol 484-17-3
A 967079 Selective TRPA1 channel blocker 1170613-55-4
AMTB hydrochloride 926023-82-7
AP 18 Reversible TRPA1 channel blocker 55224-94-7
BCTC 393514-24-4
EIPA 1154-25-2
GSK 2193874 1336960-13-4
GsMTx4
HC 067047 883031-03-6
HC-030031 TRPA1 channel blocker,potent and selective 349085-38-7
JNJ 17203212 821768-06-3
L-R4W2 206350-79-0
ML 204 5465-86-1
ML SA1 332382-54-4
OLDA 105955-11-1
Olvanil 58493-49-5
Ononetin 487-49-0
Optovin 348575-88-2
PALDA 136181-87-8
Phenamil 1161-94-0
Polygodial 6754-20-7
PPAHV 175796-50-6
Pyr3 1160514-60-2
RN 1734 946387-07-1
SB 366791 472981-92-3
SB 452533 459429-39-1
STEARDA 105955-10-0
TC-I 2000 1159996-20-9
TCS 5861528 332117-28-9
TRPC6 inhibitor 1333207-63-8
WS 12 68489-09-8
genes like me logo Genes that share compounds with TRPA1: view

Drug products for research

Transcripts for TRPA1 Gene

mRNA/cDNA for TRPA1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRPA1

Alternative Splicing Database (ASD) splice patterns (SP) for TRPA1 Gene

No ASD Table

Relevant External Links for TRPA1 Gene

GeneLoc Exon Structure for
TRPA1

Expression for TRPA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRPA1 Gene

mRNA differential expression in normal tissues according to GTEx for TRPA1 Gene

This gene is overexpressed in Bladder (x15.7), Colon - Transverse (x8.8), Small Intestine - Terminal Ileum (x7.4), and Stomach (x5.3).

Protein differential expression in normal tissues from HIPED for TRPA1 Gene

This gene is overexpressed in Urine (50.9) and Platelet (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRPA1 Gene



Protein tissue co-expression partners for TRPA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRPA1

SOURCE GeneReport for Unigene cluster for TRPA1 Gene:

Hs.716816

mRNA Expression by UniProt/SwissProt for TRPA1 Gene:

O75762-TRPA1_HUMAN
Tissue specificity: Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells (PubMed:10066796).

Evidence on tissue expression from TISSUES for TRPA1 Gene

  • Lung(4.5)
  • Nervous system(2.9)
  • Skin(2.8)
  • Stomach(2.4)
  • Kidney(2.3)
  • Intestine(2.3)
  • Muscle(2.3)
  • Heart(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with TRPA1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPA1 Gene

Orthologs for TRPA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRPA1 29 30
  • 99.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRPA1 29 30
  • 85.94 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRPA1 29 30
  • 84.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trpa1 29 16 30
  • 81.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trpa1 29
  • 80.28 (n)
Oppossum
(Monodelphis domestica)
Mammalia TRPA1 30
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TRPA1 30
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRPA1 29 30
  • 67.99 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRPA1 30
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trpa1 29
  • 60.98 (n)
Zebrafish
(Danio rerio)
Actinopterygii trpa1a 29 30
  • 55.3 (n)
OneToMany
trpa1b 30
  • 46 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004863 29
  • 47.85 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta TrpA1 29 30
  • 47.01 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea trpa-1 29 30
  • 43.78 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 22 (a)
OneToMany
-- 30
  • 21 (a)
OneToMany
Species where no ortholog for TRPA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRPA1 Gene

ENSEMBL:
Gene Tree for TRPA1 (if available)
TreeFam:
Gene Tree for TRPA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRPA1: view image
Alliance of Genome Resources:
Additional Orthologs for TRPA1

Paralogs for TRPA1 Gene

(6) SIMAP similar genes for TRPA1 Gene using alignment to 2 proteins:

  • TRPA1_HUMAN
  • H0YAW0_HUMAN

Pseudogenes.org Pseudogenes for TRPA1 Gene

genes like me logo Genes that share paralogs with TRPA1: view

No data available for Paralogs for TRPA1 Gene

Variants for TRPA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRPA1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
1013582 Likely Benign: not provided 72,053,858(-) A/G
NM_007332.3(TRPA1):c.1539T>C (p.Asn513=)
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS
1034381 Uncertain Significance: Familial episodic pain syndrome 1 72,061,644(-) G/A
NM_007332.3(TRPA1):c.925C>T (p.His309Tyr)
MISSENSE
872425 Uncertain Significance: not provided 72,036,354(-) A/G
NM_007332.3(TRPA1):c.2489T>C (p.Leu830Pro)
MISSENSE
930526 Uncertain Significance: Familial episodic pain syndrome 1 72,038,002(-) G/A
NM_007332.3(TRPA1):c.2366C>T (p.Ala789Val)
MISSENSE
rs143973551 Likely Benign: not provided 72,047,148(-) A/G
NM_007332.3(TRPA1):c.1965T>C (p.Tyr655=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRPA1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRPA1 Gene

Variant ID Type Subtype PubMed ID
esv1942504 CNV deletion 18987734
esv2737154 CNV deletion 23290073
esv2737155 CNV deletion 23290073
esv2737156 CNV deletion 23290073
esv6851 CNV gain 19470904
nsv611530 CNV loss 21841781
nsv831353 CNV loss 17160897

Variation tolerance for TRPA1 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.53; 91.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRPA1 Gene

Human Gene Mutation Database (HGMD)
TRPA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPA1
Leiden Open Variation Database (LOVD)
TRPA1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPA1 Gene

Disorders for TRPA1 Gene

MalaCards: The human disease database

(27) MalaCards diseases for TRPA1 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
episodic pain syndrome, familial, 1
  • feps1
familial episodic pain syndrome
  • feps
somatoform disorder
  • physiological malfunction arising from mental factor
dentin sensitivity
  • sensitive dentin
cramp-fasciculation syndrome
  • foley-denny-brown syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TRPA1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRPA1_HUMAN
  • Episodic pain syndrome, familial, 1 (FEPS1) [MIM:615040]: An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress. The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall. Affected individuals do not manifest altered pain sensitivity outside the episodes. {ECO:0000269 PubMed:20547126}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for TRPA1

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Publications for TRPA1 Gene

  1. A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. (PMID: 20547126) Kremeyer B … Ruiz-Linares A (Neuron 2010) 3 4 72
  2. Structure of the TRPA1 ion channel suggests regulatory mechanisms. (PMID: 25855297) Paulsen CE … Julius D (Nature 2015) 3 4
  3. QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells. (PMID: 19507004) Doihara H … Ito H (Molecular and cellular biochemistry 2009) 3 22
  4. Differentiation dependent expression of TRPA1 and TRPM8 channels in IMR-32 human neuroblastoma cells. (PMID: 19507192) Louhivuori LM … Akerman KE (Journal of cellular physiology 2009) 3 22
  5. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. (PMID: 19074743) Bessac BF … Jordt SE (Physiology (Bethesda, Md.) 2008) 3 22

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