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Aliases for TROAP Gene

Aliases for TROAP Gene

  • Trophinin Associated Protein 2 3 5
  • Tastin 2 3
  • Trophinin-Assisting Protein (Tastin) 3
  • Trophinin-Associated Protein 4
  • Trophinin Assisting Protein 3
  • Trophinin-Assisting Protein 4

External Ids for TROAP Gene

Previous GeneCards Identifiers for TROAP Gene

  • GC12P049599
  • GC12P049748
  • GC12P049434
  • GC12P048003
  • GC12P047964
  • GC12P049716
  • GC12P046747

Summaries for TROAP Gene

GeneCards Summary for TROAP Gene

TROAP (Trophinin Associated Protein) is a Protein Coding gene. Diseases associated with TROAP include Ectopic Pregnancy.

UniProtKB/Swiss-Prot for TROAP Gene

  • Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.

Gene Wiki entry for TROAP Gene

Additional gene information for TROAP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TROAP Gene

Genomics for TROAP Gene

GeneHancer (GH) Regulatory Elements for TROAP Gene

Promoters and enhancers for TROAP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I049321 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.9 922 2.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B LOC101927267 TROAP CCNT1 KANSL2 DDX23 KMT2D LMBR1L LOC390314 C1QL4 FAM186B
GH12I049293 Promoter/Enhancer 1.3 EPDnew ENCODE 4.7 -27.4 -27419 1.4 CTCF KLF1 ZSCAN4 KLF17 FEZF1 ZNF2 ZNF48 ZNF121 GLIS2 POLR2A PRPH KMT2D DDX23 KANSL2 CCNT1 SMARCD1 LMBR1L BCDIN3D LOC390314 LOC101927267
GH12I049296 Enhancer 1.2 Ensembl ENCODE 4.8 -25.0 -24999 2.2 PKNOX1 ATF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF213 ZNF302 ZNF143 KLF7 LIMA1 LOC100422296 BCDIN3D ENSG00000257298 OR5BK1P CCNT1 DDX23 KANSL2 LOC390314 KMT2D
GH12I049271 Enhancer 0.5 ENCODE 11.1 -50.5 -50484 0.7 ZSCAN21 SMAD5 POLR2A ZNF10 CEBPB CHD7 ENSG00000258232 TROAP C1QL4 ENSG00000258101 TUBA1C
GH12I049331 Enhancer 0.8 ENCODE 0.4 +9.7 9655 0.2 HDAC1 PKNOX1 SIN3A RAD21 ZBTB40 GLIS2 ZNF143 RCOR1 EGR2 ZNF654 C1QL4 TROAP GC12P049325 GC12P049321
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TROAP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TROAP gene promoter:

Genomic Locations for TROAP Gene

Genomic Locations for TROAP Gene
chr12:49,322,138-49,331,733
(GRCh38/hg38)
Size:
9,596 bases
Orientation:
Plus strand
chr12:49,716,971-49,725,514
(GRCh37/hg19)

Genomic View for TROAP Gene

Genes around TROAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TROAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TROAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TROAP Gene

Proteins for TROAP Gene

  • Protein details for TROAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12815-TROAP_HUMAN
    Recommended name:
    Tastin
    Protein Accession:
    Q12815
    Secondary Accessions:
    • F8VSF9
    • Q6PJU7
    • Q8N5B2

    Protein attributes for TROAP Gene

    Size:
    778 amino acids
    Molecular mass:
    83857 Da
    Quaternary structure:
    • Directly binds bystin, and indirectly trophinin.

    Alternative splice isoforms for TROAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TROAP Gene

Post-translational modifications for TROAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TROAP Gene

Domains & Families for TROAP Gene

Gene Families for TROAP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TROAP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TROAP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TROAP: view

No data available for UniProtKB/Swiss-Prot for TROAP Gene

Function for TROAP Gene

Molecular function for TROAP Gene

UniProtKB/Swiss-Prot Function:
Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation.

Gene Ontology (GO) - Molecular Function for TROAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9560222
genes like me logo Genes that share ontologies with TROAP: view
genes like me logo Genes that share phenotypes with TROAP: view

miRNA for TROAP Gene

Clone Products

  • Addgene plasmids for TROAP

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TROAP Gene

Localization for TROAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TROAP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TROAP gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TROAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS,IEA --
genes like me logo Genes that share ontologies with TROAP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TROAP Gene

Pathways & Interactions for TROAP Gene

SuperPathways for TROAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for TROAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA,TAS --
genes like me logo Genes that share ontologies with TROAP: view

No data available for Pathways by source and SIGNOR curated interactions for TROAP Gene

Drugs & Compounds for TROAP Gene

No Compound Related Data Available

Transcripts for TROAP Gene

Unigene Clusters for TROAP Gene

Trophinin associated protein:
Representative Sequences:

Clone Products

  • Addgene plasmids for TROAP

Alternative Splicing Database (ASD) splice patterns (SP) for TROAP Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a ·
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5: -
SP6:
SP7:
SP8:
SP9:

ExUns: 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for TROAP Gene

GeneLoc Exon Structure for
TROAP
ECgene alternative splicing isoforms for
TROAP

Expression for TROAP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TROAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TROAP Gene

This gene is overexpressed in Testis (x9.4) and Esophagus - Mucosa (x4.5).

Protein differential expression in normal tissues from HIPED for TROAP Gene

This gene is overexpressed in Heart (61.1) and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TROAP Gene



Protein tissue co-expression partners for TROAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TROAP Gene:

TROAP

SOURCE GeneReport for Unigene cluster for TROAP Gene:

Hs.524399

mRNA Expression by UniProt/SwissProt for TROAP Gene:

Q12815-TROAP_HUMAN
Tissue specificity: Strong expression at implantation sites. Was exclusively localized to the apical side of the syncytiotrophoblast. Also found in macrophages.
genes like me logo Genes that share expression patterns with TROAP: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TROAP Gene

Orthologs for TROAP Gene

This gene was present in the common ancestor of mammals.

Orthologs for TROAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TROAP 33 34
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia TROAP 33 34
  • 84.5 (n)
dog
(Canis familiaris)
Mammalia TROAP 33 34
  • 82.41 (n)
mouse
(Mus musculus)
Mammalia Troap 33 16 34
  • 75.17 (n)
rat
(Rattus norvegicus)
Mammalia Troap 33
  • 74.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TROAP 34
  • 35 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TROAP 34
  • 34 (a)
OneToOne
Species where no ortholog for TROAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TROAP Gene

ENSEMBL:
Gene Tree for TROAP (if available)
TreeFam:
Gene Tree for TROAP (if available)

Paralogs for TROAP Gene

No data available for Paralogs for TROAP Gene

Variants for TROAP Gene

Sequence variations from dbSNP and Humsavar for TROAP Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000031222 -- 49,322,567(+) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000532449 -- 49,325,941(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000857762 -- 49,330,912(+) C/G coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, synonymous_variant
rs1001064652 -- 49,324,236(+) A/G coding_sequence_variant, intron_variant, missense_variant
rs1001095693 -- 49,331,188(+) C/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TROAP Gene

Variant ID Type Subtype PubMed ID
dgv1497n100 CNV gain 25217958
nsv832405 CNV gain 17160897
nsv952175 CNV deletion 24416366

Variation tolerance for TROAP Gene

Residual Variation Intolerance Score: 80.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TROAP Gene

Human Gene Mutation Database (HGMD)
TROAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TROAP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TROAP Gene

Disorders for TROAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for TROAP Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
- elite association - COSMIC cancer census association via MalaCards
Search TROAP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TROAP

genes like me logo Genes that share disorders with TROAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TROAP Gene

Publications for TROAP Gene

  1. Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. (PMID: 7758945) Fukuda MN … Nozawa S (Genes & development 1995) 2 3 4 22 58
  2. Tastin is required for bipolar spindle assembly and centrosome integrity during mitosis. (PMID: 18218922) Yang S … Zhou J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008) 3 22 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta. (PMID: 10026108) Suzuki N … Fukuda MN (Biology of reproduction 1999) 3 22 58
  5. A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells. (PMID: 9560222) Suzuki N … Fukuda MN (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 22 58

Products for TROAP Gene

  • Addgene plasmids for TROAP

Sources for TROAP Gene

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