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Aliases for TRNAU1AP Gene

Aliases for TRNAU1AP Gene

  • TRNA Selenocysteine 1 Associated Protein 1 2 3 5
  • TRNA Selenocysteine-Associated Protein 1 3 4
  • TRSPAP1 3 4
  • SECP43 3 4
  • TRNA Selenocysteine Associated Protein (SECP43) 3
  • TRNA Selenocysteine 1-Associated Protein 1 3
  • TRNA Selenocysteine Associated Protein 1 2
  • PRO1902 3

External Ids for TRNAU1AP Gene

Previous HGNC Symbols for TRNAU1AP Gene

  • TRSPAP1

Previous GeneCards Identifiers for TRNAU1AP Gene

  • GC01P028753
  • GC01P028879
  • GC01P027133

Summaries for TRNAU1AP Gene

GeneCards Summary for TRNAU1AP Gene

TRNAU1AP (TRNA Selenocysteine 1 Associated Protein 1) is a Protein Coding gene. Among its related pathways are Selenium Metabolism and Selenoproteins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is C6orf52.

UniProtKB/Swiss-Prot for TRNAU1AP Gene

  • Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).

Additional gene information for TRNAU1AP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRNAU1AP Gene

Genomics for TRNAU1AP Gene

GeneHancer (GH) Regulatory Elements for TRNAU1AP Gene

Promoters and enhancers for TRNAU1AP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I028551 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 154 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZBTB7B TRNAU1AP PRDX3P2 SNORA61 SNORD99 SNORA73B SNHG3 RCC1 PHACTR4 RAB42 DNAJC8
GH01I028881 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 120.3 +332.2 332225 6.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 EPB41 LOC105376898 SRSF4 TRNAU1AP GMEB1 SNHG12 YTHDF2 PHACTR4 EYA3 TMEM200B
GH01I028647 Promoter/Enhancer 1.7 Ensembl ENCODE 98.6 +95.4 95428 2.7 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000270103 GC01P028651 GC01P028669 GC01P028670 GC01P028671 GC01P028672 RNU11 SRSF4 GMEB1 TRNAU1AP
GH01I028578 Promoter/Enhancer 1.6 Ensembl ENCODE 96.1 +28.2 28183 4.5 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SNHG12 GC01M028584 GC01M028612 GC01M028618 GC01M028623 GC01M028624 GC01M028625 GC01M028628 PIR59489 SNORA16A
GH01I029236 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 66.2 +685.7 685697 5.1 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 DEK PTPRU SRSF4 GMEB1 TRNAU1AP YTHDF2 SNHG12 PHACTR4 TMEM200B RCC1 ENSG00000237934
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRNAU1AP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRNAU1AP gene promoter:

Genomic Locations for TRNAU1AP Gene

Genomic Locations for TRNAU1AP Gene
chr1:28,553,017-28,578,545
(GRCh38/hg38)
Size:
25,529 bases
Orientation:
Plus strand
chr1:28,879,529-28,905,057
(GRCh37/hg19)

Genomic View for TRNAU1AP Gene

Genes around TRNAU1AP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRNAU1AP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRNAU1AP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRNAU1AP Gene

Proteins for TRNAU1AP Gene

  • Protein details for TRNAU1AP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX07-TSAP1_HUMAN
    Recommended name:
    tRNA selenocysteine 1-associated protein 1
    Protein Accession:
    Q9NX07
    Secondary Accessions:
    • Q86SU7

    Protein attributes for TRNAU1AP Gene

    Size:
    287 amino acids
    Molecular mass:
    32499 Da
    Quaternary structure:
    • Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Found in a complex with tRNA(Sec). Interacts with SEPSECS. Associates with mRNP and/or polysomes (By similarity). Found in a complex with EEFSEC, SECISBP2, TRNAU1AP and tRNA(Sec).

    Three dimensional structures from OCA and Proteopedia for TRNAU1AP Gene

    Alternative splice isoforms for TRNAU1AP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRNAU1AP Gene

Post-translational modifications for TRNAU1AP Gene

  • Ubiquitination at isoforms=2127, isoforms=2137, posLast=151151, and posLast=166166
  • Modification sites at PhosphoSitePlus

Other Protein References for TRNAU1AP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRNAU1AP Gene

Domains & Families for TRNAU1AP Gene

Gene Families for TRNAU1AP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRNAU1AP Gene

Suggested Antigen Peptide Sequences for TRNAU1AP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX07

UniProtKB/Swiss-Prot:

TSAP1_HUMAN :
  • Belongs to the RRM TRSPAP family.
Family:
  • Belongs to the RRM TRSPAP family.
genes like me logo Genes that share domains with TRNAU1AP: view

Function for TRNAU1AP Gene

Molecular function for TRNAU1AP Gene

UniProtKB/Swiss-Prot Function:
Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).

Phenotypes From GWAS Catalog for TRNAU1AP Gene

Gene Ontology (GO) - Molecular Function for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
genes like me logo Genes that share ontologies with TRNAU1AP: view
genes like me logo Genes that share phenotypes with TRNAU1AP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRNAU1AP Gene

Localization for TRNAU1AP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRNAU1AP Gene

Nucleus. Cytoplasm. Note=Abundant in the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRNAU1AP gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TRNAU1AP: view

Pathways & Interactions for TRNAU1AP Gene

genes like me logo Genes that share pathways with TRNAU1AP: view

Pathways by source for TRNAU1AP Gene

1 BioSystems pathway for TRNAU1AP Gene

Gene Ontology (GO) - Biological Process for TRNAU1AP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001514 selenocysteine incorporation ISS --
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with TRNAU1AP: view

No data available for SIGNOR curated interactions for TRNAU1AP Gene

Drugs & Compounds for TRNAU1AP Gene

No Compound Related Data Available

Transcripts for TRNAU1AP Gene

Unigene Clusters for TRNAU1AP Gene

TRNA selenocysteine 1 associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRNAU1AP Gene

No ASD Table

Relevant External Links for TRNAU1AP Gene

GeneLoc Exon Structure for
TRNAU1AP
ECgene alternative splicing isoforms for
TRNAU1AP

Expression for TRNAU1AP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRNAU1AP Gene

Protein differential expression in normal tissues from HIPED for TRNAU1AP Gene

This gene is overexpressed in Lymph node (25.5), Fetal ovary (11.3), Retina (9.2), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRNAU1AP Gene



Protein tissue co-expression partners for TRNAU1AP Gene

NURSA nuclear receptor signaling pathways regulating expression of TRNAU1AP Gene:

TRNAU1AP

SOURCE GeneReport for Unigene cluster for TRNAU1AP Gene:

Hs.533626

Evidence on tissue expression from TISSUES for TRNAU1AP Gene

  • Nervous system(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with TRNAU1AP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRNAU1AP Gene

Orthologs for TRNAU1AP Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRNAU1AP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRNAU1AP 33 34
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia TRNAU1AP 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRNAU1AP 33 34
  • 94.08 (n)
dog
(Canis familiaris)
Mammalia TRNAU1AP 33 34
  • 93.61 (n)
rat
(Rattus norvegicus)
Mammalia Trnau1ap 33
  • 93.38 (n)
mouse
(Mus musculus)
Mammalia Trnau1ap 33 16 34
  • 92.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRNAU1AP 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRNAU1AP 33 34
  • 80.26 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 40 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11585 33
African clawed frog
(Xenopus laevis)
Amphibia secp43-prov 33
zebrafish
(Danio rerio)
Actinopterygii trnau1apb 33
  • 62.06 (n)
C19H6orf52 34
  • 47 (a)
OneToMany
wufa56b07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3491 33
fruit fly
(Drosophila melanogaster)
Insecta CG15440 33 34
  • 54.65 (n)
worm
(Caenorhabditis elegans)
Secernentea T07F10.3 34
  • 15 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAM8 34 36
  • 12 (a)
ManyToMany
NGR1 34
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
OneToMany
Species where no ortholog for TRNAU1AP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRNAU1AP Gene

ENSEMBL:
Gene Tree for TRNAU1AP (if available)
TreeFam:
Gene Tree for TRNAU1AP (if available)

Paralogs for TRNAU1AP Gene

Paralogs for TRNAU1AP Gene

genes like me logo Genes that share paralogs with TRNAU1AP: view

Variants for TRNAU1AP Gene

Sequence variations from dbSNP and Humsavar for TRNAU1AP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000011644 -- 28,563,041(+) A/C intron_variant
rs1000106582 -- 28,574,299(+) G/C intron_variant
rs1000177798 -- 28,555,160(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000295474 -- 28,571,397(+) T/G intron_variant
rs1000337433 -- 28,561,430(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRNAU1AP Gene

Variant ID Type Subtype PubMed ID
dgv34e199 CNV deletion 23128226
esv3585588 CNV loss 21293372
nsv478111 CNV novel sequence insertion 20440878
nsv545916 CNV gain 21841781

Variation tolerance for TRNAU1AP Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRNAU1AP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRNAU1AP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRNAU1AP Gene

Disorders for TRNAU1AP Gene

Additional Disease Information for TRNAU1AP

No disorders were found for TRNAU1AP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRNAU1AP Gene

Publications for TRNAU1AP Gene

  1. Supramolecular complexes mediate selenocysteine incorporation in vivo. (PMID: 16508009) Small-Howard A … Berry MJ (Molecular and cellular biology 2006) 3 4 58
  2. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. (PMID: 16230358) Xu XM … Hatfield DL (The Journal of biological chemistry 2005) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Identification of a protein component of a mammalian tRNA(Sec) complex implicated in the decoding of UGA as selenocysteine. (PMID: 10606267) Ding F … Grabowski PJ (RNA (New York, N.Y.) 1999) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TRNAU1AP Gene

Sources for TRNAU1AP Gene

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