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Aliases for TRMT61B Gene

Aliases for TRMT61B Gene

  • TRNA Methyltransferase 61B 2 3 5
  • TRNA Methyltransferase 61 Homolog B (S. Cerevisiae) 2
  • MRNA Methyladenosine-N(1)-Methyltransferase 4
  • EC 2.1.1.220 4
  • EC 2.1.1.- 4

External Ids for TRMT61B Gene

Previous GeneCards Identifiers for TRMT61B Gene

  • GC02M028926
  • GC02M029072

Summaries for TRMT61B Gene

GeneCards Summary for TRMT61B Gene

TRMT61B (TRNA Methyltransferase 61B) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include protein-L-isoaspartate (D-aspartate) O-methyltransferase activity and tRNA (adenine-N1-)-methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT61B Gene

  • Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537).

Additional gene information for TRMT61B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT61B Gene

Genomics for TRMT61B Gene

GeneHancer (GH) Regulatory Elements for TRMT61B Gene

Promoters and enhancers for TRMT61B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I028868 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 594.2 +0.2 209 2.2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 TRMT61B TOGARAM2 WDR43 FOSL2 FLJ31356 ENSG00000273233
GH02I028747 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42.6 +118.2 118164 9.3 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 PPP1CB LOC100505774 TRMT61B TOGARAM2 SPDYA ENSG00000230730 WDR43 FOSL2
GH02I028821 Enhancer 1 Ensembl ENCODE 47 +48.8 48796 0.2 BCOR ELF3 CTCF RB1 ARID4B ZNF2 RAD21 CC2D1A ARID2 SCRT2 TRMT61B TOGARAM2 SPDYA WDR43 ENSG00000230730 ENSG00000273233
GH02I028802 Enhancer 0.8 FANTOM5 ENCODE 50.5 +67.2 67169 1.7 FOXA2 RFX1 MAFG ZNF316 NFE2 EMSY MAFK NFE2L2 TRMT61B WDR43 PPP1CB SPDYA ENSG00000230730 FOSL2 ENSG00000273233
GH02I028713 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.5 +154.3 154318 5.4 PKNOX1 CLOCK ATF1 SIN3A FEZF1 ZNF2 BRCA1 YY1 GTF3C2 FOS TRMT61B FOSL2 PPP1CB ENSG00000230730 WDR43 RNA5SP89 LOC100505774
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRMT61B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRMT61B gene promoter:

Genomic Locations for TRMT61B Gene

Genomic Locations for TRMT61B Gene
chr2:28,849,821-28,870,309
(GRCh38/hg38)
Size:
20,489 bases
Orientation:
Minus strand
chr2:29,072,687-29,093,175
(GRCh37/hg19)

Genomic View for TRMT61B Gene

Genes around TRMT61B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT61B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT61B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT61B Gene

Proteins for TRMT61B Gene

  • Protein details for TRMT61B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVS5-TR61B_HUMAN
    Recommended name:
    tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
    Protein Accession:
    Q9BVS5
    Secondary Accessions:
    • Q9H0Q9
    • Q9NWS7

    Protein attributes for TRMT61B Gene

    Size:
    477 amino acids
    Molecular mass:
    52965 Da
    Quaternary structure:
    • Homooligomer; in contrast to TRMT61A, does not form a heterotetramer.

    Three dimensional structures from OCA and Proteopedia for TRMT61B Gene

neXtProt entry for TRMT61B Gene

Post-translational modifications for TRMT61B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT61B Gene

No data available for DME Specific Peptides for TRMT61B Gene

Domains & Families for TRMT61B Gene

Gene Families for TRMT61B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for TRMT61B Gene

Suggested Antigen Peptide Sequences for TRMT61B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVS5

UniProtKB/Swiss-Prot:

TR61B_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
genes like me logo Genes that share domains with TRMT61B: view

Function for TRMT61B Gene

Molecular function for TRMT61B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA.
UniProtKB/Swiss-Prot Function:
Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537).

Enzyme Numbers (IUBMB) for TRMT61B Gene

Phenotypes From GWAS Catalog for TRMT61B Gene

Gene Ontology (GO) - Molecular Function for TRMT61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21903422
GO:0008168 methyltransferase activity IEA --
GO:0016429 tRNA (adenine-N1-)-methyltransferase activity IEA,IDA 23097428
GO:0016433 rRNA (adenine) methyltransferase activity IMP 27631568
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRMT61B: view
genes like me logo Genes that share phenotypes with TRMT61B: view

miRNA for TRMT61B Gene

miRTarBase miRNAs that target TRMT61B

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT61B Gene

Localization for TRMT61B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRMT61B Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT61B gene
Compartment Confidence
mitochondrion 5
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRMT61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 23097428
GO:0005759 mitochondrial matrix TAS --
GO:0031515 tRNA (m1A) methyltransferase complex IEA,IBA --
genes like me logo Genes that share ontologies with TRMT61B: view

Pathways & Interactions for TRMT61B Gene

genes like me logo Genes that share pathways with TRMT61B: view

Pathways by source for TRMT61B Gene

Gene Ontology (GO) - Biological Process for TRMT61B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation IEA --
GO:0031167 rRNA methylation IEA --
GO:0032259 methylation IEA --
GO:0051260 protein homooligomerization IDA 23097428
genes like me logo Genes that share ontologies with TRMT61B: view

No data available for SIGNOR curated interactions for TRMT61B Gene

Drugs & Compounds for TRMT61B Gene

(1) Drugs for TRMT61B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(1) Additional Compounds for TRMT61B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0
genes like me logo Genes that share compounds with TRMT61B: view

Transcripts for TRMT61B Gene

Unigene Clusters for TRMT61B Gene

TRNA methyltransferase 61 homolog B (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT61B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for TRMT61B Gene

GeneLoc Exon Structure for
TRMT61B
ECgene alternative splicing isoforms for
TRMT61B

Expression for TRMT61B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT61B Gene

Protein differential expression in normal tissues from HIPED for TRMT61B Gene

This gene is overexpressed in Heart (48.4) and Blymphocyte (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRMT61B Gene



Protein tissue co-expression partners for TRMT61B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRMT61B Gene:

TRMT61B

SOURCE GeneReport for Unigene cluster for TRMT61B Gene:

Hs.468026

Evidence on tissue expression from TISSUES for TRMT61B Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with TRMT61B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT61B Gene

Orthologs for TRMT61B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRMT61B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRMT61B 33 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia TRMT61B 33
  • 84.96 (n)
dog
(Canis familiaris)
Mammalia TRMT61B 33 34
  • 81.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRMT61B 34
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRMT61B 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRMT61B 33 34
  • 63.32 (n)
lizard
(Anolis carolinensis)
Reptilia TRMT61B 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt61b 33
  • 60.15 (n)
Str.14744 33
zebrafish
(Danio rerio)
Actinopterygii LOC100003205 33
  • 54.71 (n)
TRMT61B 34
  • 37 (a)
OneToOne
Species where no ortholog for TRMT61B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRMT61B Gene

ENSEMBL:
Gene Tree for TRMT61B (if available)
TreeFam:
Gene Tree for TRMT61B (if available)

Paralogs for TRMT61B Gene

No data available for Paralogs for TRMT61B Gene

Variants for TRMT61B Gene

Sequence variations from dbSNP and Humsavar for TRMT61B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000176198 -- 28,853,427(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000176860 -- 28,857,453(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000199297 -- 28,862,415(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000263038 -- 28,865,939(-) C/T intron_variant
rs1000507133 -- 28,853,097(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT61B Gene

Variant ID Type Subtype PubMed ID
esv2674264 CNV deletion 23128226
esv29033 CNV loss 19812545
esv3590162 CNV loss 21293372
esv3590163 CNV loss 21293372
esv3590164 CNV loss 21293372
nsv518751 CNV gain 19592680
nsv817695 CNV gain 17921354
nsv819532 CNV loss 19587683

Variation tolerance for TRMT61B Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRMT61B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRMT61B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT61B Gene

Disorders for TRMT61B Gene

Additional Disease Information for TRMT61B

No disorders were found for TRMT61B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT61B Gene

Publications for TRMT61B Gene

  1. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. (PMID: 23097428) Chujo T … Suzuki T (RNA (New York, N.Y.) 2012) 2 3 4 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. (PMID: 29107537) Li X … Yi C (Molecular cell 2017) 3 4 58
  4. Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates. (PMID: 27631568) Bar-Yaacov D … Mishmar D (PLoS biology 2016) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TRMT61B Gene

Sources for TRMT61B Gene

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