Aliases for TRMT2B Gene
External Ids for TRMT2B Gene
Previous HGNC Symbols for TRMT2B Gene
Previous GeneCards Identifiers for TRMT2B Gene
This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]
GeneCards Summary for TRMT2B Gene
TRMT2B (TRNA Methyltransferase 2 Homolog B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity. An important paralog of this gene is TRMT2A.
UniProtKB/Swiss-Prot for TRMT2B Gene
Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity).