Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRMT1L Gene

Aliases for TRMT1L Gene

  • TRNA Methyltransferase 1 Like 2 3 5
  • TRM1 TRNA Methyltransferase 1-Like 2 3
  • C1orf25 3 4
  • TRM1L 3 4
  • TRNA Methyltransferase 1 Homolog (S. Cerevisiae)-Like 2
  • TRNA Methyltransferase 1 Homolog-Like 3
  • Chromosome 1 Open Reading Frame 25 2
  • TRNA Methyltransferase 1-Like 2
  • TRMT1-Like Protein 3
  • TRM1-Like Protein 3
  • BG120K12.3 3
  • EC 2.1.1.- 4
  • TRM1-Like 2
  • MSTP070 3
  • MST070 3

External Ids for TRMT1L Gene

Previous HGNC Symbols for TRMT1L Gene

  • C1orf25

Summaries for TRMT1L Gene

Entrez Gene Summary for TRMT1L Gene

  • This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for TRMT1L Gene

TRMT1L (TRNA Methyltransferase 1 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include tRNA binding. An important paralog of this gene is TRMT1.

UniProtKB/Swiss-Prot for TRMT1L Gene

  • May play a role in motor coordination and exploratory behavior.

Additional gene information for TRMT1L Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT1L Gene

Genomics for TRMT1L Gene

GeneHancer (GH) Regulatory Elements for TRMT1L Gene

Promoters and enhancers for TRMT1L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I185154 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.7 +0.5 483 3.8 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 TRMT1L SWT1 RNF2 FTH1P25
GH01I185158 Enhancer 0.8 Ensembl dbSUPER 550.8 -1.8 -1803 0.2 SMAD1 NFIA ZNF571 NFIB ZNF491 NCOA2 NFIC LCORL ZBTB48 BCL6B TRMT1L SWT1 ENSG00000271387 GC01P185170
GH01I185015 Enhancer 1.2 FANTOM5 Ensembl ENCODE 15.9 +140.4 140388 3.2 HDAC1 MEIS2 PKNOX1 JUN CEBPG ZBTB40 FOSL1 ZNF316 FOXK2 FOSL2 GC01M185014 RNA5SP72 SWT1 RNF2 TRMT1L FAM129A IVNS1ABP EDEM3 GC01P185027
GH01I184805 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.3 +350.9 350940 1.2 PKNOX1 ATF1 SIN3A ZNF2 TCF12 GATA2 ZNF143 ATF7 RUNX3 NCOA1 FAM129A SWT1 TRMT1L GC01M184821 GC01P184758
GH01I185043 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5.8 +111.8 111781 3.4 SMAD1 SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 SP5 MXD4 REST RNF2 FAM129A TRMT1L GC01P185027
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRMT1L on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRMT1L Gene

Genomic Locations for TRMT1L Gene
39,014 bases
Minus strand

Genomic View for TRMT1L Gene

Genes around TRMT1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT1L Gene

Proteins for TRMT1L Gene

  • Protein details for TRMT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRMT1-like protein
    Protein Accession:
    Secondary Accessions:
    • Q5TEN0
    • Q6ZMX0
    • Q8IWH5
    • Q8NC68
    • Q9BZQ1

    Protein attributes for TRMT1L Gene

    733 amino acids
    Molecular mass:
    81747 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH39738.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAQ13590.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI17851.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TRMT1L Gene


neXtProt entry for TRMT1L Gene

Post-translational modifications for TRMT1L Gene

No Post-translational modifications

Other Protein References for TRMT1L Gene

No data available for DME Specific Peptides for TRMT1L Gene

Domains & Families for TRMT1L Gene

Gene Families for TRMT1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRMT1L Gene

Suggested Antigen Peptide Sequences for TRMT1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
genes like me logo Genes that share domains with TRMT1L: view

Function for TRMT1L Gene

Molecular function for TRMT1L Gene

UniProtKB/Swiss-Prot Function:
May play a role in motor coordination and exploratory behavior.

Enzyme Numbers (IUBMB) for TRMT1L Gene

Phenotypes From GWAS Catalog for TRMT1L Gene

Gene Ontology (GO) - Molecular Function for TRMT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity IEA --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with TRMT1L: view
genes like me logo Genes that share phenotypes with TRMT1L: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRMT1L Gene

Localization for TRMT1L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT1L gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRMT1L Gene

Pathways & Interactions for TRMT1L Gene

SuperPathways for TRMT1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007610 behavior IEA --
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT1L: view

No data available for Pathways by source and SIGNOR curated interactions for TRMT1L Gene

Drugs & Compounds for TRMT1L Gene

No Compound Related Data Available

Transcripts for TRMT1L Gene

Unigene Clusters for TRMT1L Gene

TRNA methyltransferase 1 homolog (S. cerevisiae)-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT1L Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for TRMT1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT1L Gene

Protein differential expression in normal tissues from HIPED for TRMT1L Gene

This gene is overexpressed in Lung (36.4) and Colon muscle (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRMT1L Gene

Protein tissue co-expression partners for TRMT1L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRMT1L Gene:


SOURCE GeneReport for Unigene cluster for TRMT1L Gene:


mRNA Expression by UniProt/SwissProt for TRMT1L Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TRMT1L Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with TRMT1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT1L Gene

Orthologs for TRMT1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRMT1L 33 34
  • 99.68 (n)
(Canis familiaris)
Mammalia TRMT1L 33 34
  • 94.36 (n)
(Bos Taurus)
Mammalia TRMT1L 33 34
  • 92.87 (n)
(Mus musculus)
Mammalia Trmt1l 33 16 34
  • 86.72 (n)
(Rattus norvegicus)
Mammalia Trmt1l 33
  • 86.68 (n)
(Ornithorhynchus anatinus)
Mammalia TRMT1L 34
  • 75 (a)
(Monodelphis domestica)
Mammalia TRMT1L 34
  • 63 (a)
(Gallus gallus)
Aves TRMT1L 33 34
  • 75.03 (n)
(Anolis carolinensis)
Reptilia TRMT1L 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt1l 33
  • 64.88 (n)
Str.15557 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33986 33
(Danio rerio)
Actinopterygii trmt1l 33 34
  • 62.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6388 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea trm-1 34
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM1 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6910 34
  • 18 (a)
Species where no ortholog for TRMT1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT1L Gene

Gene Tree for TRMT1L (if available)
Gene Tree for TRMT1L (if available)

Paralogs for TRMT1L Gene

Paralogs for TRMT1L Gene

genes like me logo Genes that share paralogs with TRMT1L: view

Variants for TRMT1L Gene

Sequence variations from dbSNP and Humsavar for TRMT1L Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000010247 -- 185,131,643(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000038501 -- 185,157,720(-) T/C upstream_transcript_variant
rs1000112858 -- 185,158,068(-) A/G upstream_transcript_variant
rs1000138030 -- 185,157,436(-) C/T upstream_transcript_variant
rs1000291428 -- 185,119,045(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT1L Gene

Variant ID Type Subtype PubMed ID
nsv548397 CNV gain 21841781
nsv548396 CNV loss 21841781
nsv521613 CNV loss 19592680
esv3575349 CNV gain 25503493

Variation tolerance for TRMT1L Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRMT1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT1L Gene

Disorders for TRMT1L Gene

Additional Disease Information for TRMT1L

No disorders were found for TRMT1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT1L Gene

Publications for TRMT1L Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R … Carpten JD (Genomics 2001) 2 3 4 58
  2. The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. (PMID: 17198746) Vauti F … Arnold HH (Gene 2007) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for TRMT1L Gene

Sources for TRMT1L Gene

Loading form....