This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this... See more...

Aliases for TRMT1L Gene

Aliases for TRMT1L Gene

  • TRNA Methyltransferase 1 Like 2 3 5
  • TRM1 TRNA Methyltransferase 1-Like 2 3
  • TRMT1-Like Protein 3 4
  • C1orf25 3 4
  • TRM1L 3 4
  • TRNA Methyltransferase 1 Homolog (S. Cerevisiae)-Like 2
  • TRNA Methyltransferase 1 Homolog-Like 3
  • Chromosome 1 Open Reading Frame 25 2
  • TRNA Methyltransferase 1-Like 2
  • TRM1-Like Protein 3
  • BG120K12.3 3
  • EC 2.1.1.- 4
  • TRM1-Like 2
  • MSTP070 3
  • MST070 3
  • TRMT1L 5

External Ids for TRMT1L Gene

Previous HGNC Symbols for TRMT1L Gene

  • C1orf25

Previous GeneCards Identifiers for TRMT1L Gene

  • GC01M185088

Summaries for TRMT1L Gene

Entrez Gene Summary for TRMT1L Gene

  • This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for TRMT1L Gene

TRMT1L (TRNA Methyltransferase 1 Like) is a Protein Coding gene. Diseases associated with TRMT1L include Desmoid Disease, Hereditary. Gene Ontology (GO) annotations related to this gene include tRNA binding. An important paralog of this gene is TRMT1.

UniProtKB/Swiss-Prot Summary for TRMT1L Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRMT1L Gene

Genomics for TRMT1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRMT1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J185154 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 256.6 +0.4 445 3.9 SP1 ZNF207 MYC ZNF600 SIX5 KLF9 POLR2A CEBPA NFIC ZIC2 TRMT1L SWT1 lnc-TRMT1L-1 ENSG00000238061 RNF2 HSALNG0009041
GH01J185015 Enhancer 1.1 FANTOM5 Ensembl ENCODE 15.9 +140.8 140797 4.2 JUND ZNF592 REST CEBPB EP300 ZNF316 NFE2 EHMT2 MAFK FOXK2 RF00001-021 RNA5SP72 SWT1 RNF2 TRMT1L NIBAN1 ENSG00000271387 IVNS1ABP EDEM3 piR-48369-010
GH01J184805 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.3 +350.6 350597 2.2 BCLAF1 IKZF1 ZNF654 NCOR1 CEBPA ZNF10 CTCF REST CEBPB TRIM22 HSALNG0009027 NIBAN1 SWT1 TRMT1L EDEM3 LOC107985238
GH01J185043 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 5.8 +111.4 111381 4.2 MYC ZNF600 ZNF592 ZNF10 POLR2A CHD4 ZBTB10 YY1 MXD4 NONO RNF2 SWT1 NIBAN1 TRMT1L FTH1P25 lnc-TRMT1L-3
GH01J184982 Enhancer 1 Ensembl ENCODE 10.7 +174.9 174896 0.8 BCLAF1 ZNF654 MYC ZIC2 CTCF REST TRIM22 ARNT HCFC1 NBN SWT1 TRMT1L NIBAN1 ENSG00000233583 LINC01633 RNF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRMT1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRMT1L

Genomic Locations for TRMT1L Gene

Latest Assembly
chr1:185,118,101-185,157,098
(GRCh38/hg38)
Size:
38,998 bases
Orientation:
Minus strand

Previous Assembly
chr1:185,087,233-185,126,230
(GRCh37/hg19 by Entrez Gene)
Size:
38,998 bases
Orientation:
Minus strand

chr1:185,087,220-185,126,204
(GRCh37/hg19 by Ensembl)
Size:
38,985 bases
Orientation:
Minus strand

Genomic View for TRMT1L Gene

Genes around TRMT1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT1L Gene

Proteins for TRMT1L Gene

  • Protein details for TRMT1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2T5-TRM1L_HUMAN
    Recommended name:
    TRMT1-like protein
    Protein Accession:
    Q7Z2T5
    Secondary Accessions:
    • Q5TEN0
    • Q6ZMX0
    • Q8IWH5
    • Q8NC68
    • Q9BZQ1

    Protein attributes for TRMT1L Gene

    Size:
    733 amino acids
    Molecular mass:
    81747 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39738.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAQ13590.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRMT1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRMT1L Gene

Post-translational modifications for TRMT1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMT1L Gene

Antibodies for research

  • Santa Cruz Biotechnology (SCBT) Antibodies for TRMT1L

No data available for DME Specific Peptides for TRMT1L Gene

Domains & Families for TRMT1L Gene

Gene Families for TRMT1L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRMT1L Gene

Suggested Antigen Peptide Sequences for TRMT1L Gene

GenScript: Design optimal peptide antigens:
  • TRMT1-like protein (TRM1L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z2T5

UniProtKB/Swiss-Prot:

TRM1L_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
genes like me logo Genes that share domains with TRMT1L: view

Function for TRMT1L Gene

Molecular function for TRMT1L Gene

UniProtKB/Swiss-Prot Function:
May play a role in motor coordination and exploratory behavior.

Enzyme Numbers (IUBMB) for TRMT1L Gene

Phenotypes From GWAS Catalog for TRMT1L Gene

Gene Ontology (GO) - Molecular Function for TRMT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 32814053
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with TRMT1L: view
genes like me logo Genes that share phenotypes with TRMT1L: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRMT1L

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRMT1L Gene

Localization for TRMT1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT1L gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRMT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with TRMT1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRMT1L Gene

Pathways & Interactions for TRMT1L Gene

PathCards logo

SuperPathways for TRMT1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRMT1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002940 tRNA N2-guanine methylation IBA 21873635
GO:0007610 behavior IEA --
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT1L: view

No data available for Pathways by source and SIGNOR curated interactions for TRMT1L Gene

Drugs & Compounds for TRMT1L Gene

No Compound Related Data Available

Transcripts for TRMT1L Gene

mRNA/cDNA for TRMT1L Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRMT1L

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT1L Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c
SP1: - - - - -
SP2: - -
SP3: -
SP4: -
SP5:

Relevant External Links for TRMT1L Gene

GeneLoc Exon Structure for
TRMT1L

Expression for TRMT1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRMT1L Gene

Protein differential expression in normal tissues from HIPED for TRMT1L Gene

This gene is overexpressed in Lung (36.4) and Colon muscle (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRMT1L Gene



Protein tissue co-expression partners for TRMT1L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRMT1L

SOURCE GeneReport for Unigene cluster for TRMT1L Gene:

Hs.107149

mRNA Expression by UniProt/SwissProt for TRMT1L Gene:

Q7Z2T5-TRM1L_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TRMT1L Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with TRMT1L: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT1L Gene

Orthologs for TRMT1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRMT1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TRMT1L 29 30
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TRMT1L 29 30
  • 94.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TRMT1L 29 30
  • 92.87 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Trmt1l 29 16 30
  • 86.72 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Trmt1l 29
  • 86.68 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia TRMT1L 30
  • 75 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TRMT1L 30
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TRMT1L 29 30
  • 75.03 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TRMT1L 30
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia trmt1l 29
  • 64.88 (n)
Str.15557 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.33986 29
Zebrafish
(Danio rerio)
Actinopterygii trmt1l 29 30
  • 62.9 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6388 30
  • 18 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea trm-1 30
  • 17 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM1 30
  • 16 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6910 30
  • 18 (a)
OneToMany
Species where no ortholog for TRMT1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TRMT1L Gene

ENSEMBL:
Gene Tree for TRMT1L (if available)
TreeFam:
Gene Tree for TRMT1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRMT1L: view image
Alliance of Genome Resources:
Additional Orthologs for TRMT1L

Paralogs for TRMT1L Gene

Paralogs for TRMT1L Gene

genes like me logo Genes that share paralogs with TRMT1L: view

Variants for TRMT1L Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TRMT1L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TRMT1L Gene

Variant ID Type Subtype PubMed ID
esv3575349 CNV gain 25503493
nsv521613 CNV loss 19592680
nsv548396 CNV loss 21841781
nsv548397 CNV gain 21841781

Variation tolerance for TRMT1L Gene

Residual Variation Intolerance Score: 12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRMT1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRMT1L
Leiden Open Variation Database (LOVD)
TRMT1L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRMT1L Gene

Disorders for TRMT1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRMT1L Gene - From: COP

Disorder Aliases PubMed IDs
desmoid disease, hereditary
  • desmd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRMT1L

genes like me logo Genes that share disorders with TRMT1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRMT1L Gene

Publications for TRMT1L Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R … Carpten JD (Genomics 2001) 2 3 4
  2. The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. (PMID: 17198746) Vauti F … Arnold HH (Gene 2007) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis. (PMID: 32838362) Li J … Liang Q (Med (New York, N.Y.) 2021) 3
  5. Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. (PMID: 32457219) Tran DT … Itkin-Ansari P (Diabetes 2020) 3

Products for TRMT1L Gene

Sources for TRMT1L Gene