Aliases for TRMT112 Gene
External Ids for TRMT112 Gene
Previous GeneCards Identifiers for TRMT112 Gene
GeneCards Summary for TRMT112 Gene
TRMT112 (TRNA Methyltransferase Subunit 11-2) is a Protein Coding gene. Among its related pathways are tRNA processing and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include protein methyltransferase activity.
UniProtKB/Swiss-Prot Summary for TRMT112 Gene
Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:25851604). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604).