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Aliases for TRMT11 Gene

Aliases for TRMT11 Gene

  • TRNA Methyltransferase 11 Homolog 2 3 5
  • TRNA Guanosine-2-O-Methyltransferase TRM11 Homolog 3 4
  • C6orf75 3 4
  • TRNA Methyltransferase 11 Homolog (S. Cerevisiae) 2
  • TRNA (Guanine(10)-N2)-Methyltransferase Homolog 3
  • Chromosome 6 Open Reading Frame 75 2
  • EC 56
  • EC 2.1.1.- 4
  • TRMT11-1 3
  • EC 2.1.1 56
  • MDS024 3
  • TRM11 3

External Ids for TRMT11 Gene

Previous HGNC Symbols for TRMT11 Gene

  • C6orf75

Previous GeneCards Identifiers for TRMT11 Gene

  • GC06P126350
  • GC06P126307
  • GC06P123883

Summaries for TRMT11 Gene

GeneCards Summary for TRMT11 Gene

TRMT11 (TRNA Methyltransferase 11 Homolog) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and N-methyltransferase activity.

UniProtKB/Swiss-Prot for TRMT11 Gene

  • Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

Additional gene information for TRMT11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMT11 Gene

Genomics for TRMT11 Gene

GeneHancer (GH) Regulatory Elements for TRMT11 Gene

Promoters and enhancers for TRMT11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I125983 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565.2 -1.1 -1064 4.7 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TRMT11 HINT3 RNA5SP216
GH06I125013 Enhancer 1.4 FANTOM5 Ensembl ENCODE 44.8 -972.2 -972230 2.4 ATF1 FEZF1 ZNF2 NCOA2 ZNF766 ZNF548 ATF7 KLF13 YY2 ZNF662 TRMT11 RNF217 RNF217-AS1 GC06P125084
GH06I125955 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.8 -29.4 -29369 3.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 HINT3 CENPW TRMT11 NCOA7 RNA5SP216
GH06I125810 Enhancer 1.4 Ensembl ENCODE dbSUPER 26.6 -174.2 -174199 2.5 PKNOX1 ARNT FEZF1 ZNF2 ZNF213 ZNF302 E2F8 FOS SP3 JUNB TRMT11 RNF217-AS1 NCOA7-AS1 NCOA7
GH06I125779 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12.6 -204.9 -204932 3.4 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NCOA7 TRE-CTC1-7 HEY2 CENPW TRMT11 RNF217-AS1 RNF217 NCOA7-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRMT11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRMT11 gene promoter:

Genomic Locations for TRMT11 Gene

Genomic Locations for TRMT11 Gene
52,847 bases
Plus strand

Genomic View for TRMT11 Gene

Genes around TRMT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMT11 Gene

Proteins for TRMT11 Gene

  • Protein details for TRMT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA (guanine(10)-N2)-methyltransferase homolog
    Protein Accession:
    Secondary Accessions:
    • E1P570
    • Q5JY11
    • Q6PGQ5
    • Q9HC13

    Protein attributes for TRMT11 Gene

    463 amino acids
    Molecular mass:
    53421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRMT11 Gene


neXtProt entry for TRMT11 Gene

Selected DME Specific Peptides for TRMT11 Gene


Post-translational modifications for TRMT11 Gene

No Post-translational modifications

Domains & Families for TRMT11 Gene

Gene Families for TRMT11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.
genes like me logo Genes that share domains with TRMT11: view

Function for TRMT11 Gene

Molecular function for TRMT11 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

Enzyme Numbers (IUBMB) for TRMT11 Gene

Phenotypes From GWAS Catalog for TRMT11 Gene

Gene Ontology (GO) - Molecular Function for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity EXP 15899842
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with TRMT11: view
genes like me logo Genes that share phenotypes with TRMT11: view

Animal Model Products

miRNA for TRMT11 Gene

miRTarBase miRNAs that target TRMT11

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMT11 Gene

Localization for TRMT11 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRMT11 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRMT11 Gene

Pathways & Interactions for TRMT11 Gene

genes like me logo Genes that share pathways with TRMT11: view

Pathways by source for TRMT11 Gene

Gene Ontology (GO) - Biological Process for TRMT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with TRMT11: view

No data available for SIGNOR curated interactions for TRMT11 Gene

Drugs & Compounds for TRMT11 Gene

(1) Additional Compounds for TRMT11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
genes like me logo Genes that share compounds with TRMT11: view

Transcripts for TRMT11 Gene

Unigene Clusters for TRMT11 Gene

TRNA methyltransferase 11 homolog (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRMT11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: -
SP2: - - -
SP4: - - - - - - - - - - - - -

Relevant External Links for TRMT11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRMT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRMT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRMT11 Gene

This gene is overexpressed in Heart (52.4) and Lung (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRMT11 Gene

Protein tissue co-expression partners for TRMT11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRMT11 Gene:


SOURCE GeneReport for Unigene cluster for TRMT11 Gene:


Evidence on tissue expression from TISSUES for TRMT11 Gene

  • Liver(4.2)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with TRMT11: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRMT11 Gene

Orthologs for TRMT11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRMT11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRMT11 33 34
  • 99.64 (n)
(Canis familiaris)
Mammalia TRMT11 33 34
  • 92.25 (n)
(Bos Taurus)
Mammalia TRMT11 33 34
  • 91.88 (n)
(Mus musculus)
Mammalia Trmt11 33 16 34
  • 89.71 (n)
(Rattus norvegicus)
Mammalia Trmt11 33
  • 88.62 (n)
(Monodelphis domestica)
Mammalia TRMT11 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia TRMT11 34
  • 82 (a)
(Gallus gallus)
Aves TRMT11 33 34
  • 75.45 (n)
(Anolis carolinensis)
Reptilia TRMT11 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trmt11 33
  • 72.33 (n)
Str.16718 33
(Danio rerio)
Actinopterygii trmt11 33 34
  • 65.44 (n)
zgc56233 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002384 33
  • 49.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1074 33 34
  • 48.1 (n)
(Caenorhabditis elegans)
Secernentea Y71F9AL.1 33 34
  • 47.88 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12903g 33
  • 49.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM11 33 34 36
  • 48.85 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL161C 33
  • 44.74 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G26410 33
  • 49.96 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes trm11 33
  • 46.95 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04407 33
  • 44.73 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.613 33
Species where no ortholog for TRMT11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRMT11 Gene

Gene Tree for TRMT11 (if available)
Gene Tree for TRMT11 (if available)

Paralogs for TRMT11 Gene Pseudogenes for TRMT11 Gene

genes like me logo Genes that share paralogs with TRMT11: view

No data available for Paralogs for TRMT11 Gene

Variants for TRMT11 Gene

Sequence variations from dbSNP and Humsavar for TRMT11 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000069262 -- 126,024,838(+) A/G intron_variant
rs1000109155 -- 126,053,021(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000153322 -- 126,046,403(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000167743 -- 125,992,543(+) A/G intron_variant
rs1000173943 -- 125,985,244(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRMT11 Gene

Variant ID Type Subtype PubMed ID
nsv830796 CNV loss 17160897
nsv527938 CNV loss 19592680
nsv1025069 CNV loss 25217958
nsv1022677 CNV gain 25217958
nsv1019490 CNV loss 25217958
esv3328863 CNV insertion 20981092
esv3307064 CNV mobile element insertion 20981092

Variation tolerance for TRMT11 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRMT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRMT11 Gene

Disorders for TRMT11 Gene

Additional Disease Information for TRMT11

No disorders were found for TRMT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMT11 Gene

Publications for TRMT11 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation features. (PMID: 22223895) Bienvenut WV … Giglione C (Molecular & cellular proteomics : MCP 2012) 4 58

Products for TRMT11 Gene

Sources for TRMT11 Gene

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