Aliases for TRMT10A Gene
External Ids for TRMT10A Gene
Previous HGNC Symbols for TRMT10A Gene
Previous GeneCards Identifiers for TRMT10A Gene
This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
GeneCards Summary for TRMT10A Gene
TRMT10A (TRNA Methyltransferase 10A) is a Protein Coding gene. Diseases associated with TRMT10A include Microcephaly, Short Stature, And Impaired Glucose Metabolism 1 and Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome. Among its related pathways are tRNA processing and Gene Expression. Gene Ontology (GO) annotations related to this gene include tRNA binding. An important paralog of this gene is TRMT10B.
UniProtKB/Swiss-Prot Summary for TRMT10A Gene
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).