Aliases for TRIT1 Gene
External Ids for TRIT1 Gene
Previous GeneCards Identifiers for TRIT1 Gene
This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]
GeneCards Summary for TRIT1 Gene
TRIT1 (TRNA Isopentenyltransferase 1) is a Protein Coding gene. Diseases associated with TRIT1 include Combined Oxidative Phosphorylation Deficiency 35 and Noonan Syndrome 5. Among its related pathways are tRNA processing and Metabolism. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and dimethylallyltranstransferase activity.
UniProtKB/Swiss-Prot Summary for TRIT1 Gene
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).