Aliases for TRIR Gene

Aliases for TRIR Gene

  • Telomerase RNA Component Interacting RNase 2 3 4 5
  • Exoribonuclease TRIR 3 4
  • C19orf43 3 4
  • TERCIR 2 3
  • FSAP18 2 3
  • Functional Spliceosome-Associated Protein 18 2
  • Chromosome 19 Open Reading Frame 43 2
  • Uncharacterized Protein C19orf43 3
  • My029 Protein 3
  • EC 3.1.13.- 4
  • MGC2803 2
  • TRIR 5

External Ids for TRIR Gene

Previous HGNC Symbols for TRIR Gene

  • C19orf43

Previous GeneCards Identifiers for TRIR Gene

  • GC19M012794
  • GC19M012803
  • GC19M012790
  • GC19M012865
  • GC19M012732
  • GC19M012741
  • GC19M012750
  • GC19M012777

Summaries for TRIR Gene

GeneCards Summary for TRIR Gene

TRIR (Telomerase RNA Component Interacting RNase) is a Protein Coding gene. Diseases associated with TRIR include Retinitis Pigmentosa 47 and Tinea Unguium.

UniProtKB/Swiss-Prot Summary for TRIR Gene

  • Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335).

Additional gene information for TRIR Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIR Gene

Genomics for TRIR Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TRIR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIR on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIR

Genomic Locations for TRIR Gene

Genomic Locations for TRIR Gene
4,045 bases
Minus strand
4,136 bases
Minus strand

Genomic View for TRIR Gene

Genes around TRIR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIR Gene

Proteins for TRIR Gene

  • Protein details for TRIR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Telomerase RNA component interacting RNase
    Protein Accession:

    Protein attributes for TRIR Gene

    176 amino acids
    Molecular mass:
    18419 Da
    Quaternary structure:
    • Part of the telomerase RNA 3' end complex which contains about 488 proteins (PubMed:28322335).

neXtProt entry for TRIR Gene

Post-translational modifications for TRIR Gene

  • Ubiquitination at Lys146 and Lys152
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIR Gene

No data available for DME Specific Peptides for TRIR Gene

Domains & Families for TRIR Gene

Gene Families for TRIR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRIR Gene


Graphical View of Domain Structure for InterPro Entry



  • The C-terminus contains a key domain which is responsible for the RNA digestion activity (PubMed:28322335).
  • The C-terminus contains a key domain which is responsible for the RNA digestion activity (PubMed:28322335).
genes like me logo Genes that share domains with TRIR: view

No data available for Suggested Antigen Peptide Sequences for TRIR Gene

Function for TRIR Gene

Molecular function for TRIR Gene

UniProtKB/Swiss-Prot Function:
Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.5-12. {ECO:0000269|PubMed:28322335}; Temperature dependence: Optimum temperature is 37-75 degrees Celsius. {ECO:0000269|PubMed:28322335};
UniProtKB/Swiss-Prot EnzymeRegulation:
Zn(2+) inhibits the RNase activity while Mg(2+), Ca(2+), Mn(2+), K(+), Na(+), EDTA and EGTA show little effect on the exoribonuclease activity (PubMed:28322335).

Enzyme Numbers (IUBMB) for TRIR Gene

Phenotypes From GWAS Catalog for TRIR Gene

Gene Ontology (GO) - Molecular Function for TRIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0008408 3'-5' exonuclease activity IEA,IDA 28322335
genes like me logo Genes that share ontologies with TRIR: view
genes like me logo Genes that share phenotypes with TRIR: view

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIR Gene

Localization for TRIR Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIR gene
Compartment Confidence
nucleus 3
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIR Gene

Pathways & Interactions for TRIR Gene

PathCards logo

SuperPathways for TRIR Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016075 rRNA catabolic process IDA 28322335
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA,IDA 28322335
genes like me logo Genes that share ontologies with TRIR: view

No data available for Pathways by source and SIGNOR curated interactions for TRIR Gene

Drugs & Compounds for TRIR Gene

No Compound Related Data Available

Transcripts for TRIR Gene

mRNA/cDNA for TRIR Gene

11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRIR Gene

No ASD Table

Relevant External Links for TRIR Gene

GeneLoc Exon Structure for

Expression for TRIR Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIR

Evidence on tissue expression from TISSUES for TRIR Gene

  • Nervous system(4.7)
  • Muscle(4.6)
  • Liver(3)
  • Heart(2.9)
  • Kidney(2.9)
  • Skin(2.9)
  • Blood(2.8)
  • Intestine(2.8)
  • Spleen(2.7)
  • Lung(2.6)
  • Eye(2.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIR Gene

Orthologs for TRIR Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C19H19orf43 30
  • 100 (n)
C19orf43 31
  • 100 (a)
(Bos Taurus)
Mammalia C7H19orf43 30 31
  • 93.56 (n)
(Canis familiaris)
Mammalia C20H19orf43 30
  • 93.18 (n)
C19orf43 31
  • 67 (a)
(Mus musculus)
Mammalia 2310036O22Rik 30 31
  • 92.05 (n)
Trir 17
(Rattus norvegicus)
Mammalia RGD1564093 30
  • 91.28 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 71 (a)
-- 31
  • 70 (a)
(Anolis carolinensis)
Reptilia C19orf43 31
  • 65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6514 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.528 30
(Danio rerio)
Actinopterygii LOC560758 30
  • 56.77 (n)
C3H19orf43 31
  • 46 (a)
Dr.15916 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG18809 31
  • 18 (a)
Species where no ortholog for TRIR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TRIR Gene

Gene Tree for TRIR (if available)
Gene Tree for TRIR (if available)

Paralogs for TRIR Gene

No data available for Paralogs for TRIR Gene

Variants for TRIR Gene

Additional dbSNP identifiers (rs#s) for TRIR Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIR Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for TRIR Gene

Gene Damage Index Score: 0.11; 2.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIR Gene

Disorders for TRIR Gene

MalaCards: The human disease database

(6) MalaCards diseases for TRIR Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search TRIR in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TRIR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIR Gene

Publications for TRIR Gene

  1. Identification of an RNase that preferentially cleaves A/G nucleotides. (PMID: 28322335) Xie J … Guan W (Scientific reports 2017) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells. (PMID: 30585729) Abbasi S … Schild-Poulter C (Journal of proteome research 2019) 3
  5. Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. (PMID: 28515276) Malinová A … Verheggen C (The Journal of cell biology 2017) 3

Products for TRIR Gene

Sources for TRIR Gene