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Aliases for TRIR Gene

Aliases for TRIR Gene

  • Telomerase RNA Component Interacting RNase 2 3 4 5
  • Exoribonuclease TRIR 3 4
  • C19orf43 3 4
  • Functional Spliceosome-Associated Protein 18 2
  • Chromosome 19 Open Reading Frame 43 2
  • Uncharacterized Protein C19orf43 3
  • My029 Protein 3
  • EC 3.1.13.- 4
  • TERCIR 3
  • FSAP18 3

External Ids for TRIR Gene

Previous HGNC Symbols for TRIR Gene

  • C19orf43

Previous GeneCards Identifiers for TRIR Gene

  • GC19M012794
  • GC19M012732
  • GC19M012741
  • GC19M012750
  • GC19M012777

Summaries for TRIR Gene

GeneCards Summary for TRIR Gene

TRIR (Telomerase RNA Component Interacting RNase) is a Protein Coding gene. Diseases associated with TRIR include Tinea Unguium.

UniProtKB/Swiss-Prot for TRIR Gene

  • Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335).

Additional gene information for TRIR Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIR Gene

Genomics for TRIR Gene

GeneHancer (GH) Regulatory Elements for TRIR Gene

Promoters and enhancers for TRIR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J012733 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 611.7 -1.2 -1186 5.8 SP1 CC2D1A CTCF ZFX ELF3 SIX5 CBFA2T2 ZNF148 NKRF POLR2A TRIR GET3 ZNF136 CCDC130 ZNF442 ZNF791 ZNF44 ZNF564 ZNF763 WDR83OS
GH19J013148 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 46.9 -418.7 -418677 10.8 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 MNT SIX5 ZNF148 NKRF STX10 ENSG00000267598 IER2 CCDC130 ZNF136 TRMT1 ZNF44 ZNF564 WDR83OS RFX1
GH19J012781 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 43.6 -54.6 -54583 16 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 CTCF MNT SIX5 CBFA2T2 IER2 CCDC130 ZNF136 ZNF44 ZNF791 ZNF564 TRMT1 WDR83OS ZNF442 MRI1
GH19J011923 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 42.4 +809.1 809114 4.4 HDGF ZNF652 ZFX SP1 CTCF ZNF148 NKRF POLR2A ZNF121 CEBPG ZNF700 ENSG00000267179 ZNF627 ZNF136 ZNF44 ZNF763 ZNF20 ZNF564 ZNF442 ZNF791
GH19J012774 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26.1 -42.7 -42691 6.2 SP1 ZFX ELF3 CTCF ZKSCAN8 MNT SIX5 CBFA2T2 ZNF148 NKRF GC19P012779 HOOK2 CCDC130 WDR83OS ZNF44 ZNF564 ZNF700 ZNF136 ZNF799 TRIR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIR on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRIR Gene

Genomic Locations for TRIR Gene
chr19:12,730,640-12,734,715
(GRCh38/hg38)
Size:
4,076 bases
Orientation:
Minus strand
chr19:12,841,454-12,845,589
(GRCh37/hg19)
Size:
4,136 bases
Orientation:
Minus strand

Genomic View for TRIR Gene

Genes around TRIR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIR Gene

Proteins for TRIR Gene

  • Protein details for TRIR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ61-TRIR_HUMAN
    Recommended name:
    Telomerase RNA component interacting RNase
    Protein Accession:
    Q9BQ61

    Protein attributes for TRIR Gene

    Size:
    176 amino acids
    Molecular mass:
    18419 Da
    Quaternary structure:
    • Part of the telomerase RNA 3' end complex which contains about 488 proteins (PubMed:28322335).

neXtProt entry for TRIR Gene

Post-translational modifications for TRIR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIR Gene

No data available for DME Specific Peptides for TRIR Gene

Domains & Families for TRIR Gene

Gene Families for TRIR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRIR Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BQ61

UniProtKB/Swiss-Prot:

TRIR_HUMAN :
  • The C-terminus contains a key domain which is responsible for the RNA digestion activity (PubMed:28322335).
Domain:
  • The C-terminus contains a key domain which is responsible for the RNA digestion activity (PubMed:28322335).
genes like me logo Genes that share domains with TRIR: view

No data available for Suggested Antigen Peptide Sequences for TRIR Gene

Function for TRIR Gene

Molecular function for TRIR Gene

UniProtKB/Swiss-Prot Function:
Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335).
UniProtKB/Swiss-Prot EnzymeRegulation:
Zn(2+) inhibits the RNase activity while Mg(2+), Ca(2+), Mn(2+), K(+), Na(+), EDTA and EGTA show little effect on the exoribonuclease activity (PubMed:28322335).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.5-12. {ECO:0000269 PubMed:28322335}; Temperature dependence: Optimum temperature is 37-75 degrees Celsius. {ECO:0000269 PubMed:28322335};

Enzyme Numbers (IUBMB) for TRIR Gene

Phenotypes From GWAS Catalog for TRIR Gene

Gene Ontology (GO) - Molecular Function for TRIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0008408 3'-5' exonuclease activity IEA,IDA 28322335
genes like me logo Genes that share ontologies with TRIR: view
genes like me logo Genes that share phenotypes with TRIR: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TRIR - Now 50% OFF >
  • * TRIR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TRIR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIR Gene

Localization for TRIR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIR gene
Compartment Confidence
nucleus 3
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIR Gene

Pathways & Interactions for TRIR Gene

PathCards logo

SuperPathways for TRIR Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016075 rRNA catabolic process IDA 28322335
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IDA,IEA 28322335
genes like me logo Genes that share ontologies with TRIR: view

No data available for Pathways by source and SIGNOR curated interactions for TRIR Gene

Drugs & Compounds for TRIR Gene

No Compound Related Data Available

Transcripts for TRIR Gene

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for TRIR - Now 50% OFF >
  • * TRIR as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TRIR tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TRIR Gene

No ASD Table

Relevant External Links for TRIR Gene

GeneLoc Exon Structure for
TRIR
ECgene alternative splicing isoforms for
TRIR

Expression for TRIR Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIR Gene:

TRIR

Evidence on tissue expression from TISSUES for TRIR Gene

  • Nervous system(4.6)
  • Muscle(4.5)
  • Intestine(2.8)
  • Spleen(2.7)
  • Liver(2.6)
  • Lung(2.6)
  • Heart(2.5)
  • Kidney(2.5)
  • Blood(2.2)
  • Thyroid gland(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIR Gene

Orthologs for TRIR Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19orf43 35
  • 100 (a)
OneToOne
C19H19orf43 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia C7H19orf43 35 34
  • 93.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf43 34
  • 93.18 (n)
C19orf43 35
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310036O22Rik 35 34
  • 92.05 (n)
OneToOne
Trir 17
rat
(Rattus norvegicus)
Mammalia RGD1564093 34
  • 91.28 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia C19orf43 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.528 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6514 34
zebrafish
(Danio rerio)
Actinopterygii LOC560758 34
  • 56.77 (n)
C3H19orf43 35
  • 46 (a)
OneToOne
Dr.15916 34
fruit fly
(Drosophila melanogaster)
Insecta CG18809 35
  • 18 (a)
OneToOne
Species where no ortholog for TRIR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIR Gene

ENSEMBL:
Gene Tree for TRIR (if available)
TreeFam:
Gene Tree for TRIR (if available)

Paralogs for TRIR Gene

No data available for Paralogs for TRIR Gene

Variants for TRIR Gene

Sequence variations from dbSNP and Humsavar for TRIR Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000278000 -- 12,732,795(-) G/A intron_variant
rs1000389236 -- 12,733,966(-) G/C intron_variant
rs1000879915 -- 12,731,445(-) C/A intron_variant, non_coding_transcript_variant
rs1001663408 -- 12,735,402(-) C/T upstream_transcript_variant
rs1001706220 -- 12,732,080(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIR Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
nsv1160586 CNV duplication 26073780
nsv953977 CNV deletion 24416366

Variation tolerance for TRIR Gene

Gene Damage Index Score: 0.11; 2.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIR Gene

Disorders for TRIR Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIR Gene - From: DISEASES

Disorder Aliases PubMed IDs
tinea unguium
  • cellulitis and abscess
- elite association - COSMIC cancer census association via MalaCards
Search TRIR in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TRIR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIR Gene

Publications for TRIR Gene

  1. Identification of an RNase that preferentially cleaves A/G nucleotides. (PMID: 28322335) Xie J … Guan W (Scientific reports 2017) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. (PMID: 28515276) Malinová A … Verheggen C (The Journal of cell biology 2017) 3 58
  4. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. (PMID: 26752685) Scholz CC … Taylor CT (PLoS biology 2016) 3 58
  5. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. (PMID: 27634302) Oliviero G … Cagney G (Molecular & cellular proteomics : MCP 2016) 3 58

Products for TRIR Gene

Sources for TRIR Gene

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