Aliases for TRIP6 Gene
External Ids for TRIP6 Gene
Previous GeneCards Identifiers for TRIP6 Gene
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIP6 Gene
TRIP6 (Thyroid Hormone Receptor Interactor 6) is a Protein Coding gene. Diseases associated with TRIP6 include Lipomatosis, Multiple and Spinal Cord Astrocytoma. Among its related pathways are NOD-like receptor signaling pathway and LPA receptor mediated events. Gene Ontology (GO) annotations related to this gene include thyroid hormone receptor binding. An important paralog of this gene is ZYX.
UniProtKB/Swiss-Prot Summary for TRIP6 Gene
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.