This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode diff... See more...

Aliases for TRIP6 Gene

Aliases for TRIP6 Gene

  • Thyroid Hormone Receptor Interactor 6 2 3 5
  • Thyroid Receptor-Interacting Protein 6 3 4
  • TR-Interacting Protein 6 3 4
  • TRIP-6 3 4
  • OIP-1 3 4
  • ZRP-1 3 4
  • OIP1 3 4
  • Thyroid Hormone Receptor Interacting Protein 6 3
  • OPA-Interacting Protein 1 3
  • Opa-Interacting Protein 1 4
  • Zyxin Related Protein 1 3
  • Zyxin-Related Protein 1 4
  • TRIP6i2 3

External Ids for TRIP6 Gene

Previous GeneCards Identifiers for TRIP6 Gene

  • GC07U990119
  • GC07P098999
  • GC07P100062
  • GC07P100076
  • GC07P100109
  • GC07P100302
  • GC07P100464
  • GC07P095095

Summaries for TRIP6 Gene

Entrez Gene Summary for TRIP6 Gene

  • This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIP6 Gene

TRIP6 (Thyroid Hormone Receptor Interactor 6) is a Protein Coding gene. Diseases associated with TRIP6 include Lipomatosis, Multiple and Spinal Cord Astrocytoma. Among its related pathways are NOD-like receptor signaling pathway and LPA receptor mediated events. Gene Ontology (GO) annotations related to this gene include thyroid hormone receptor binding. An important paralog of this gene is ZYX.

UniProtKB/Swiss-Prot Summary for TRIP6 Gene

  • Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.

Gene Wiki entry for TRIP6 Gene

Additional gene information for TRIP6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIP6 Gene

Genomics for TRIP6 Gene

GeneHancer (GH) Regulatory Elements for TRIP6 Gene

Promoters and enhancers for TRIP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100865 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 523.2 +1.1 1099 4.3 ZNF217 TCF12 MYC USF1 GTF2E2 PHF8 JUND TEAD4 FOS ZFX TRIP6 MIR6875 TRIM4 ZNF3 SRRT GIGYF1 STAG3L5P ACHE PPP1R35 PILRB
GH07J100894 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 21.8 +30.0 30016 4.9 HNRNPK CTCF NRF1 USF1 RBAK PHB2 ZNF639 ZNF10 ZIC2 ZBTB10 ACHE SRRT PPP1R35 MOSPD3 GIGYF1 TRIM4 MEPCE ZNF3 ENSG00000242798 AP4M1
GH07J101813 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 15.6 +950.4 950380 6 CTCF ZSCAN5C SIN3A NRF1 POLR2G USF1 SP1 PHF8 ZFX ZNF639 CUX1 HSALNG0060135 TRIP6 SRRT EPHB4 ENSG00000259294
GH07J100873 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 13.8 +9.4 9380 4 RXRA ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G SP1 SRRT lnc-UFSP1-2 piR-47652 GIGYF1 STAG3L5P AP4M1 PILRB TRIM4 PPP1R35 ZNF3
GH07J101169 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 15.6 +303.8 303780 0.8 CTCF NRF1 ZNF639 REST ZBTB10 ZBTB26 TARDBP RAD21 CTBP1 MYC VGF PILRB SRRT TRIP6 MEPCE FBXO24 GIGYF1 STAG3L5P PPP1R35 ZCWPW1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIP6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIP6

Top Transcription factor binding sites by QIAGEN in the TRIP6 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • STAT1

Genomic Locations for TRIP6 Gene

Genomic Locations for TRIP6 Gene
chr7:100,866,221-100,873,455
(GRCh38/hg38)
Size:
7,235 bases
Orientation:
Plus strand
chr7:100,464,760-100,471,076
(GRCh37/hg19)
Size:
6,317 bases
Orientation:
Plus strand

Genomic View for TRIP6 Gene

Genes around TRIP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP6 Gene

Proteins for TRIP6 Gene

  • Protein details for TRIP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15654-TRIP6_HUMAN
    Recommended name:
    Thyroid receptor-interacting protein 6
    Protein Accession:
    Q15654
    Secondary Accessions:
    • A4D2E7
    • F2ZC07
    • F2ZC08
    • O15170
    • O15275
    • Q9BTB2
    • Q9BUE5
    • Q9BXP3
    • Q9UNT4

    Protein attributes for TRIP6 Gene

    Size:
    476 amino acids
    Molecular mass:
    50288 Da
    Quaternary structure:
    • Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone (PubMed:14688263). Interacts (via the third LIM domain and C-terminus) with PTPN13 (via the second PDZ domain) (PubMed:10400701, PubMed:17591779, PubMed:19017743, PubMed:10826496). Interacts (via the second LIM domain or via the third LIM domain plus C-terminus) with PDLIM4 (via PDZ domain) (PubMed:10826496). Found in a complex with PTPN13 and PDLIM4 (By similarity). Interacts with SVIL isoform 2 (PubMed:16880273). Interacts with LPAR2 but not other LPA receptors (PubMed:14688263). Interacts with PRKAA2 (PubMed:16624523). Interacts with MAGI1 (PubMed:19017743). Interacts with SCRIB (PubMed:16137684). In case of infection, interacts with S.typhimurium protein sseI (PubMed:17095609).
    SequenceCaution:
    • Sequence=AAC41740.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIP6 Gene

    Alternative splice isoforms for TRIP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIP6 Gene

Post-translational modifications for TRIP6 Gene

  • Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIP6 Gene

No data available for DME Specific Peptides for TRIP6 Gene

Domains & Families for TRIP6 Gene

Gene Families for TRIP6 Gene

Protein Domains for TRIP6 Gene

Blocks:
  • Zn-binding protein, LIM
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIP6 Gene

GenScript: Design optimal peptide antigens:
  • Zyxin-related protein 1 (TRIP6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15654

UniProtKB/Swiss-Prot:

TRIP6_HUMAN :
  • The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.
  • Belongs to the zyxin/ajuba family.
Domain:
  • The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI.
Family:
  • Belongs to the zyxin/ajuba family.
genes like me logo Genes that share domains with TRIP6: view

Function for TRIP6 Gene

Molecular function for TRIP6 Gene

UniProtKB/Swiss-Prot Function:
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
GENATLAS Biochemistry:
thyroid receptor interacting protein 6,homolog to LPP and ZYX (see symbols)

Phenotypes From GWAS Catalog for TRIP6 Gene

Gene Ontology (GO) - Molecular Function for TRIP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005149 interleukin-1 receptor binding IDA 15657077
GO:0005515 protein binding IPI 10826496
GO:0019900 kinase binding IPI 15657077
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIP6: view
genes like me logo Genes that share phenotypes with TRIP6: view

Animal Models for TRIP6 Gene

MGI Knock Outs for TRIP6:
  • Trip6 Trip6<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for TRIP6 Gene

miRTarBase miRNAs that target TRIP6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIP6

Clone Products

  • Addgene plasmids for TRIP6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIP6 Gene

Localization for TRIP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP6 Gene

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm (PubMed:16624523). Colocalizes with actin (PubMed:10826496). {ECO:0000269 PubMed:10826496, ECO:0000269 PubMed:16624523}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIP6 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 4
nucleus 4
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Focal adhesion sites (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IBA 21873635
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TRIP6: view

Pathways & Interactions for TRIP6 Gene

genes like me logo Genes that share pathways with TRIP6: view

Pathways by source for TRIP6 Gene

1 BioSystems pathway for TRIP6 Gene
1 KEGG pathway for TRIP6 Gene

SIGNOR curated interactions for TRIP6 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TRIP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction IBA 21873635
GO:0030335 positive regulation of cell migration IMP 14688263
GO:0048041 focal adhesion assembly NAS 14688263
GO:1901224 positive regulation of NIK/NF-kappaB signaling IBA,IDA 15657077
genes like me logo Genes that share ontologies with TRIP6: view

Drugs & Compounds for TRIP6 Gene

(1) Drugs for TRIP6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TRIP6: view

Transcripts for TRIP6 Gene

mRNA/cDNA for TRIP6 Gene

1 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIP6

Clone Products

  • Addgene plasmids for TRIP6

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5: - - -
SP6:

Relevant External Links for TRIP6 Gene

GeneLoc Exon Structure for
TRIP6

Expression for TRIP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIP6 Gene

Protein differential expression in normal tissues from HIPED for TRIP6 Gene

This gene is overexpressed in Bone marrow stromal cell (26.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIP6 Gene



Protein tissue co-expression partners for TRIP6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIP6

SOURCE GeneReport for Unigene cluster for TRIP6 Gene:

Hs.534360

mRNA Expression by UniProt/SwissProt for TRIP6 Gene:

Q15654-TRIP6_HUMAN
Tissue specificity: Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas. Expressed in colonic epithelial cells. Up-regulated in colonic tumors.

Evidence on tissue expression from TISSUES for TRIP6 Gene

  • Kidney(4.3)
  • Liver(4.3)
  • Pancreas(4.3)
  • Nervous system(3.5)
  • Lung(3)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with TRIP6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIP6 Gene

Orthologs for TRIP6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIP6 31 30
  • 99.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRIP6 31 30
  • 87.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRIP6 31 30
  • 87.16 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trip6 30
  • 84.38 (n)
mouse
(Mus musculus)
Mammalia Trip6 17 31 30
  • 83.61 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIP6 31
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIP6 31
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC792697 30
  • 65.25 (n)
BX322601.2 31
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Zyx 31
  • 26 (a)
OneToMany
Species where no ortholog for TRIP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIP6 Gene

ENSEMBL:
Gene Tree for TRIP6 (if available)
TreeFam:
Gene Tree for TRIP6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIP6: view image

Paralogs for TRIP6 Gene

Paralogs for TRIP6 Gene

(9) SIMAP similar genes for TRIP6 Gene using alignment to 2 proteins:

  • TRIP6_HUMAN
  • H7BZE2_HUMAN
genes like me logo Genes that share paralogs with TRIP6: view

Variants for TRIP6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIP6 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
781044 Benign: not provided 100,868,220(+) G/A MISSENSE_VARIANT
rs17855370 - p.Leu296Phe
rs2075756 - p.Val230Ile
rs2437100 - p.Arg111Gln

Additional dbSNP identifiers (rs#s) for TRIP6 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIP6 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
esv2759547 CNV gain+loss 17122850
nsv1020837 CNV loss 25217958
nsv5870 CNV insertion 18451855
nsv607965 CNV loss 21841781
nsv607966 CNV loss 21841781
nsv831073 CNV loss 17160897

Variation tolerance for TRIP6 Gene

Residual Variation Intolerance Score: 71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.67; 86.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIP6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP6 Gene

Disorders for TRIP6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIP6 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
lipomatosis, multiple
  • lipomatosis, familial multiple; fml
spinal cord astrocytoma
  • astrocytoma of spinal cord
- elite association - COSMIC cancer census association via MalaCards
Search TRIP6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRIP6

genes like me logo Genes that share disorders with TRIP6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIP6 Gene

Publications for TRIP6 Gene

  1. The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. (PMID: 9598321) Yi J … Beckerle MC (Genomics 1998) 2 3 4 23 54
  2. Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. (PMID: 16880273) Takizawa N … Luna EJ (The Journal of cell biology 2006) 3 4 23 54
  3. The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. (PMID: 16137684) Petit MM … Van de Ven WJ (FEBS letters 2005) 3 4 23 54
  4. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. (PMID: 14688263) Xu J … Lin FT (The Journal of biological chemistry 2004) 3 4 23 54
  5. ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E. (PMID: 10400701) Murthy KK … Banville D (The Journal of biological chemistry 1999) 3 4 23 54

Products for TRIP6 Gene

  • Signalway ELISA kits for TRIP6
  • Signalway Proteins for TRIP6

Sources for TRIP6 Gene