This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with ... See more...

Aliases for TRIP4 Gene

Aliases for TRIP4 Gene

  • Thyroid Hormone Receptor Interactor 4 2 3 5
  • Thyroid Receptor-Interacting Protein 4 3 4
  • Activating Signal Cointegrator 1 3 4
  • TR-Interacting Protein 4 3 4
  • Zinc Finger, C2HC5-Type 2 3
  • TRIP-4 3 4
  • ASC-1 3 4
  • Activating Signal Cointegrator-1 2
  • HsT17391 3
  • SMABF1 3
  • ZC2HC5 3
  • MDCDC 3
  • ASC1 3

External Ids for TRIP4 Gene

Previous GeneCards Identifiers for TRIP4 Gene

  • GC15P060490
  • GC15P057839
  • GC15P062258
  • GC15P062395
  • GC15P062467
  • GC15P064683
  • GC15P041503
  • GC15P064768
  • GC15P064876
  • GC15P065758
  • GC15P064425
  • GC15P065363
  • GC15P069483
  • GC15P069586
  • GC15P069643
  • GC15P065422
  • GC15P066296
  • GC15P066846
  • GC15P067372
  • GC15P067897
  • GC15P068388
  • GC15P068894
  • GC15P069371

Summaries for TRIP4 Gene

Entrez Gene Summary for TRIP4 Gene

  • This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]

GeneCards Summary for TRIP4 Gene

TRIP4 (Thyroid Hormone Receptor Interactor 4) is a Protein Coding gene. Diseases associated with TRIP4 include Muscular Dystrophy, Congenital, Davignon-Chauveau Type and Spinal Muscular Atrophy With Congenital Bone Fractures 1. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and estrogen receptor binding.

UniProtKB/Swiss-Prot Summary for TRIP4 Gene

  • Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity).

Gene Wiki entry for TRIP4 Gene

Additional gene information for TRIP4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIP4 Gene

Genomics for TRIP4 Gene

GeneHancer (GH) Regulatory Elements for TRIP4 Gene

Promoters and enhancers for TRIP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIP4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIP4

Top Transcription factor binding sites by QIAGEN in the TRIP4 gene promoter:
  • c-Myb
  • Evi-1
  • FOXO1
  • FOXO1a
  • IRF-1
  • Pbx1a
  • RORalpha1

Genomic Locations for TRIP4 Gene

Genomic Locations for TRIP4 Gene
chr15:64,387,748-64,455,303
(GRCh38/hg38)
Size:
67,556 bases
Orientation:
Plus strand
chr15:64,679,947-64,747,502
(GRCh37/hg19)
Size:
67,556 bases
Orientation:
Plus strand

Genomic View for TRIP4 Gene

Genes around TRIP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP4 Gene

Proteins for TRIP4 Gene

  • Protein details for TRIP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15650-TRIP4_HUMAN
    Recommended name:
    Activating signal cointegrator 1
    Protein Accession:
    Q15650
    Secondary Accessions:
    • B2RAS0
    • Q96ED7
    • Q9UKH0

    Protein attributes for TRIP4 Gene

    Size:
    581 amino acids
    Molecular mass:
    66146 Da
    Quaternary structure:
    • Interacts with the thyroid hormone receptor/TR (via the ligand-binding domain); this interaction requires the presence of thyroid hormone (PubMed:10454579). Interacts with the androgen receptor/AR; in an androgen, testosterone and dihydrotestosterone-dependent manner (PubMed:12390891). Interacts with ESR1 (estrogen ligand-bound); competes with UFSP2 (PubMed:10454579, PubMed:25219498). Interacts with UFSP2; competes with ligand-bound ESR1 (PubMed:25219498). Interacts with DDRGK1 and UFL1; the interaction with DDRGK1 is direct (PubMed:25219498). Interacts with NCOA1 (PubMed:25219498). Interacts with EP300 (PubMed:25219498). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Interacts with NEK6 (PubMed:20873783). Interacts with CSRP1 (PubMed:26924529).
    SequenceCaution:
    • Sequence=AAC41738.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIP4 Gene

neXtProt entry for TRIP4 Gene

Post-translational modifications for TRIP4 Gene

  • Phosphorylated by NEK6.
  • Polyufmylated by the UFM1-conjugating system composed of the enzymes UBA5, UFC1 and UFL1. Deufmylated by the protease UFSP2. Ufmylation of TRIP4 is promoted by ligand-bound nuclear receptors that compete with UFSP2 for interaction with TRIP4. Nuclear receptors-induced ufmylation promotes the recruitment of additional transcriptional coactivators like EP300 and NCOA1 and therefore the assembly of a coactivator complex facilitating nuclear receptor-mediated transcription.
  • Ubiquitination at Lys245 and Lys367
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIP4 Gene

No data available for DME Specific Peptides for TRIP4 Gene

Domains & Families for TRIP4 Gene

Gene Families for TRIP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TRIP4 Gene

Blocks:
  • Putative zinc finger, C2HC5-type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIP4 Gene

GenScript: Design optimal peptide antigens:
  • Thyroid receptor-interacting protein 4 (TRIP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15650

UniProtKB/Swiss-Prot:

TRIP4_HUMAN :
  • The C4-type zinc finger mediates a competitive interaction with UFSP2 and ligand-bound nuclear receptors. It also mediates interaction with the transcriptional coactivators and the basal transcription machinery.
Domain:
  • The C4-type zinc finger mediates a competitive interaction with UFSP2 and ligand-bound nuclear receptors. It also mediates interaction with the transcriptional coactivators and the basal transcription machinery.
genes like me logo Genes that share domains with TRIP4: view

Function for TRIP4 Gene

Molecular function for TRIP4 Gene

UniProtKB/Swiss-Prot Function:
Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity).

Phenotypes From GWAS Catalog for TRIP4 Gene

Gene Ontology (GO) - Molecular Function for TRIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 25219498
GO:0003713 transcription coactivator activity IBA,IMP 25219498
GO:0005515 protein binding IPI 25219498
GO:0008270 zinc ion binding IEA --
GO:0016922 nuclear receptor binding IDA 10454579
genes like me logo Genes that share ontologies with TRIP4: view
genes like me logo Genes that share phenotypes with TRIP4: view

Human Phenotype Ontology for TRIP4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIP4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIP4 Gene

Localization for TRIP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP4 Gene

Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269 PubMed:10454579, ECO:0000269 PubMed:20873783}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIP4 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10454579
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 10454579
GO:0005813 colocalizes_with centrosome IDA 20873783
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with TRIP4: view

Pathways & Interactions for TRIP4 Gene

PathCards logo

SuperPathways for TRIP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,IMP 26924529
GO:0030520 intracellular estrogen receptor signaling pathway IDA 25219498
GO:0045661 regulation of myoblast differentiation IEA,ISS --
GO:0045893 positive regulation of transcription, DNA-templated IBA,IMP 25219498
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with TRIP4: view

No data available for Pathways by source and SIGNOR curated interactions for TRIP4 Gene

Drugs & Compounds for TRIP4 Gene

No Compound Related Data Available

Transcripts for TRIP4 Gene

mRNA/cDNA for TRIP4 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIP4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a ·
SP1: - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: - -
SP9: - - - - -
SP10:
SP11:
SP12:

ExUns: 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TRIP4 Gene

GeneLoc Exon Structure for
TRIP4

Expression for TRIP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIP4 Gene

Protein differential expression in normal tissues from HIPED for TRIP4 Gene

This gene is overexpressed in Stomach (33.7) and Lung (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIP4 Gene



Protein tissue co-expression partners for TRIP4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIP4

SOURCE GeneReport for Unigene cluster for TRIP4 Gene:

Hs.500340

Evidence on tissue expression from TISSUES for TRIP4 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with TRIP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIP4 Gene

Orthologs for TRIP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIP4 31 30
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRIP4 31 30
  • 91.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRIP4 31 30
  • 90.06 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Trip4 17 31 30
  • 88.76 (n)
rat
(Rattus norvegicus)
Mammalia Trip4 30
  • 87.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIP4 31
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIP4 31
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIP4 31 30
  • 68.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIP4 31
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8014 30
zebrafish
(Danio rerio)
Actinopterygii trip4 31 30
  • 63.47 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11710 31 32 30
  • 49.84 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000554 30
  • 49.84 (n)
worm
(Caenorhabditis elegans)
Secernentea asc-1 31 32 30
  • 45.5 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1169 31
  • 43 (a)
OneToOne
Species where no ortholog for TRIP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIP4 Gene

ENSEMBL:
Gene Tree for TRIP4 (if available)
TreeFam:
Gene Tree for TRIP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIP4: view image

Paralogs for TRIP4 Gene

Pseudogenes.org Pseudogenes for TRIP4 Gene

genes like me logo Genes that share paralogs with TRIP4: view

No data available for Paralogs for TRIP4 Gene

Variants for TRIP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIP4 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
709482 Likely Benign: not provided 64,414,113(+) A/G MISSENSE_VARIANT
710055 Benign: not provided 64,409,766(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
710472 Benign: not provided 64,394,102(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
714598 Benign: not provided 64,395,495(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
722401 Likely Benign: not provided 64,409,739(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for TRIP4 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIP4 Gene

Variant ID Type Subtype PubMed ID
esv2749784 CNV deletion 23290073
esv3892709 CNV loss 25118596
nsv1134459 CNV deletion 24896259

Variation tolerance for TRIP4 Gene

Residual Variation Intolerance Score: 39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIP4 Gene

Human Gene Mutation Database (HGMD)
TRIP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIP4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP4 Gene

Disorders for TRIP4 Gene

MalaCards: The human disease database

(11) MalaCards diseases for TRIP4 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TRIP4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TRIP4_HUMAN
  • Spinal muscular atrophy with congenital bone fractures 1 (SMABF1) [MIM:616866]: An autosomal recessive neuromuscular disorder characterized by prenatal-onset spinal muscular atrophy, multiple congenital contractures consistent with arthrogryposis multiplex congenita, respiratory distress, and congenital bone fractures. {ECO:0000269 PubMed:26924529}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Muscular dystrophy, congenital, Davignon-Chauveau type (MDCDC) [MIM:617066]: An autosomal recessive, severe congenital muscular dystrophy characterized by neonatal onset of muscle weakness predominantly involving axial muscles, life-threatening respiratory failure, skin abnormalities and joint hyperlaxity without contractures. Muscle biopsies show multi-minicores, caps and dystrophic lesions. {ECO:0000269 PubMed:27008887}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TRIP4

genes like me logo Genes that share disorders with TRIP4: view

No data available for Genatlas for TRIP4 Gene

Publications for TRIP4 Gene

  1. Novel transcription coactivator complex containing activating signal cointegrator 1. (PMID: 12077347) Jung DJ … Lee YC (Molecular and cellular biology 2002) 2 3 4 54
  2. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee JW … Moore DD (Molecular endocrinology (Baltimore, Md.) 1995) 2 3 4 54
  3. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. (PMID: 26924529) Knierim E … Schuelke M (American journal of human genetics 2016) 3 4 54
  4. The transcription coactivator ASC-1 is a regulator of skeletal myogenesis, and its deficiency causes a novel form of congenital muscle disease. (PMID: 27008887) Davignon L … Ferreiro A (Human molecular genetics 2016) 3 4 54
  5. Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. (PMID: 25219498) Yoo HM … Chung CH (Molecular cell 2014) 3 4 54

Products for TRIP4 Gene