Aliases for TRIP13 Gene
External Ids for TRIP13 Gene
Previous GeneCards Identifiers for TRIP13 Gene
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
GeneCards Summary for TRIP13 Gene
TRIP13 (Thyroid Hormone Receptor Interactor 13) is a Protein Coding gene. Diseases associated with TRIP13 include Mosaic Variegated Aneuploidy Syndrome 3 and Mosaic Variegated Aneuploidy Syndrome. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription cofactor activity.
UniProtKB/Swiss-Prot for TRIP13 Gene
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959).