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Aliases for TRIOBP Gene

Aliases for TRIOBP Gene

  • TRIO And F-Actin Binding Protein 2 3 5
  • Trio-Associated Repeat On Actin 3 4
  • Protein Tara 3 4
  • TARA 3 4
  • TRIO And F-Actin-Binding Protein 3
  • Tara-Like Protein 3
  • HRIHFB2122 3
  • DJ37E16.4 3
  • KIAA1662 4
  • DFNB28 3
  • TAP68 3

External Ids for TRIOBP Gene

Previous HGNC Symbols for TRIOBP Gene

  • DFNB28

Previous GeneCards Identifiers for TRIOBP Gene

  • GC22P036447
  • GC22P038092
  • GC22P021064

Summaries for TRIOBP Gene

Entrez Gene Summary for TRIOBP Gene

  • This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]

GeneCards Summary for TRIOBP Gene

TRIOBP (TRIO And F-Actin Binding Protein) is a Protein Coding gene. Diseases associated with TRIOBP include Deafness, Autosomal Recessive 28 and Nonsyndromic Deafness. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and GTP-Rho binding. An important paralog of this gene is MPRIP.

UniProtKB/Swiss-Prot for TRIOBP Gene

  • May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.

Gene Wiki entry for TRIOBP Gene

Additional gene information for TRIOBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIOBP Gene

Genomics for TRIOBP Gene

GeneHancer (GH) Regulatory Elements for TRIOBP Gene

Promoters and enhancers for TRIOBP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J037745 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672.5 +53.7 53727 10.9 HDGF PKNOX1 FOXA2 SIN3A FEZF1 YY1 GLIS2 ZNF207 FOS RUNX3 TRIOBP H1F0 GCAT GGA1 LGALS2 PICK1 LGALS1 ANKRD54 POLR2F CDC42EP1
GH22J037695 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 660.8 -0.2 -185 2.1 HDGF SIN3A ZNF121 GLIS2 ZNF143 KLF7 FOS SP3 SMARCB1 GLIS1 TRIOBP EIF3L GC22P037690 ENSG00000100101
GH22J038174 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.5 +481.8 481821 8.7 MLX DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 MCM3 SP3 PLA2G6 DDX17 MAFF ENSG00000228274 PRDX3P1 CSNK1E ANKRD54 CBY1 ENSG00000230912 TRIOBP
GH22J037738 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 42.2 +44.7 44651 6.2 MLX ZNF133 ZNF143 FOS RXRA NFIL3 GLIS1 RCOR2 HMBOX1 HNF4A TRIOBP H1F0 GCAT GGA1 ANKRD54 LOC102724378
GH22J037683 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.3 -11.2 -11228 3.7 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 NOL12 ENSG00000100101 ENSG00000230912 CSNK1E CBY1 TRIOBP ANKRD54 ENSG00000228274 DDX17 LL22NC01-81G9.3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIOBP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIOBP gene promoter:

Genomic Locations for TRIOBP Gene

Genomic Locations for TRIOBP Gene
79,569 bases
Plus strand

Genomic View for TRIOBP Gene

Genes around TRIOBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIOBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIOBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIOBP Gene

Proteins for TRIOBP Gene

  • Protein details for TRIOBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRIO and F-actin-binding protein
    Protein Accession:
    Secondary Accessions:
    • B1AHD4
    • B1AHD7
    • F2Z2W0
    • F8W6V6
    • O94797
    • Q2PZW8
    • Q2Q3Z9
    • Q2Q400
    • Q5R3M6
    • Q96DW1
    • Q9BT77
    • Q9BTL7
    • Q9BY98
    • Q9Y3L4

    Protein attributes for TRIOBP Gene

    2365 amino acids
    Molecular mass:
    261376 Da
    Quaternary structure:
    • Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3.
    • Has been identified in PubMed:9853615 by a selection system for genes encoding nuclear-targeted protein.
    • Sequence=BAA34800.1; Type=Frameshift; Positions=478; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIOBP Gene

neXtProt entry for TRIOBP Gene

Post-translational modifications for TRIOBP Gene

  • Ubiquitinated by HECTD3, leading to its degradation by the proteasome.
  • Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIOBP Gene

Domains & Families for TRIOBP Gene

Gene Families for TRIOBP Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TRIOBP Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains at least 2 actin-binding sites per coiled-coil dimer.
  • Contains at least 2 actin-binding sites per coiled-coil dimer.
genes like me logo Genes that share domains with TRIOBP: view

Function for TRIOBP Gene

Molecular function for TRIOBP Gene

UniProtKB/Swiss-Prot Function:
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.

Phenotypes From GWAS Catalog for TRIOBP Gene

Gene Ontology (GO) - Molecular Function for TRIOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017049 GTP-Rho binding NAS 11148140
GO:0031625 ubiquitin protein ligase binding IPI 18194665
GO:0045159 myosin II binding NAS 11148140
GO:0051015 actin filament binding IEA,IDA 11148140
genes like me logo Genes that share ontologies with TRIOBP: view
genes like me logo Genes that share phenotypes with TRIOBP: view

Human Phenotype Ontology for TRIOBP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRIOBP Gene

MGI Knock Outs for TRIOBP:

Animal Model Products

miRNA for TRIOBP Gene

miRTarBase miRNAs that target TRIOBP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TRIOBP Gene

Localization for TRIOBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIOBP Gene

Nucleus. Cytoplasm, cytoskeleton. Note=Localized to F-actin in a periodic pattern.
Isoform 1: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIOBP gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with TRIOBP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIOBP Gene

Pathways & Interactions for TRIOBP Gene

SuperPathways for TRIOBP Gene

No Data Available

SIGNOR curated interactions for TRIOBP Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRIOBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007605 sensory perception of sound IEA --
GO:0030047 actin modification NAS 11148140
GO:0032956 regulation of actin cytoskeleton organization IEA --
GO:0051016 barbed-end actin filament capping NAS 11148140
genes like me logo Genes that share ontologies with TRIOBP: view

No data available for Pathways by source for TRIOBP Gene

Drugs & Compounds for TRIOBP Gene

No Compound Related Data Available

Transcripts for TRIOBP Gene


Unigene Clusters for TRIOBP Gene

TRIO and F-actin binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIOBP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - - - -
SP2: - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP10: - -
SP11: - - -
SP12: - - - - - -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d ^ 22a · 22b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP11: - - - - - - - -
SP13: -

Relevant External Links for TRIOBP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIOBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIOBP Gene

Protein differential expression in normal tissues from HIPED for TRIOBP Gene

This gene is overexpressed in Urinary Bladder (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIOBP Gene

Protein tissue co-expression partners for TRIOBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIOBP Gene:


SOURCE GeneReport for Unigene cluster for TRIOBP Gene:


mRNA Expression by UniProt/SwissProt for TRIOBP Gene:

Tissue specificity: Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.

Evidence on tissue expression from TISSUES for TRIOBP Gene

  • Nervous system(4.7)
  • Pancreas(4.4)
  • Intestine(4.2)
  • Liver(4.2)
  • Eye(3)
  • Skin(3)
  • Lung(2.9)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIOBP Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • nervous
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • head
  • inner ear
  • middle ear
  • outer ear
  • skull
  • peripheral nerve
  • peripheral nervous system
genes like me logo Genes that share expression patterns with TRIOBP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRIOBP Gene

Orthologs for TRIOBP Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIOBP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIOBP 34 33
  • 89.56 (n)
(Pan troglodytes)
Mammalia TRIOBP 34
  • 87 (a)
(Canis familiaris)
Mammalia TRIOBP 34 33
  • 84.79 (n)
(Rattus norvegicus)
Mammalia Triobp 33
  • 79.98 (n)
(Mus musculus)
Mammalia Triobp 16 34 33
  • 79.69 (n)
(Ornithorhynchus anatinus)
Mammalia TRIOBP 34
  • 65 (a)
(Monodelphis domestica)
Mammalia TRIOBP 34
  • 45 (a)
(Gallus gallus)
Aves LOC100859397 33
  • 74.98 (n)
-- 34
  • 56 (a)
-- 34
  • 48 (a)
(Anolis carolinensis)
Reptilia TRIOBP 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia triobp 33
  • 62.99 (n)
Str.1356 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.12480 33
(Danio rerio)
Actinopterygii triobp 34
  • 39 (a)
TRIOBP (2 of 2) 34
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta osp 34
  • 12 (a)
(Caenorhabditis elegans)
Secernentea F10G8.8 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
Species where no ortholog for TRIOBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIOBP Gene

Gene Tree for TRIOBP (if available)
Gene Tree for TRIOBP (if available)
Evolutionary constrained regions (ECRs) for TRIOBP: view image

Paralogs for TRIOBP Gene

Paralogs for TRIOBP Gene

(3) SIMAP similar genes for TRIOBP Gene using alignment to 8 proteins:

  • F6TR96_HUMAN
  • F8W6V6_HUMAN
  • H0Y5J9_HUMAN
  • H0Y5T8_HUMAN
  • H7BXW4_HUMAN Pseudogenes for TRIOBP Gene

genes like me logo Genes that share paralogs with TRIOBP: view

Variants for TRIOBP Gene

Sequence variations from dbSNP and Humsavar for TRIOBP Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1060499809 pathogenic, Deafness, autosomal recessive 28 37,724,003(+) C/T coding_sequence_variant, genic_upstream_transcript_variant, stop_gained
rs118204026 pathogenic, Deafness, autosomal recessive 28 37,723,595(+) C/G/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, stop_gained
rs118204027 pathogenic, Deafness, autosomal recessive 28 37,724,297(+) C/T coding_sequence_variant, genic_upstream_transcript_variant, stop_gained
rs118204028 pathogenic, Deafness, autosomal recessive 28 37,723,445(+) C/T coding_sequence_variant, genic_upstream_transcript_variant, stop_gained
rs118204029 pathogenic, Deafness, autosomal recessive 28 37,724,918(+) C/T coding_sequence_variant, genic_upstream_transcript_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for TRIOBP Gene

Variant ID Type Subtype PubMed ID
esv1471410 CNV deletion 17803354
esv2658988 CNV deletion 23128226
esv2660524 CNV deletion 23128226
esv2724218 CNV deletion 23290073
esv2724219 CNV deletion 23290073
esv2758838 CNV loss 17122850
esv3575478 CNV gain 25503493
esv3647716 CNV loss 21293372
esv3647717 CNV loss 21293372
esv3647718 CNV loss 21293372
nsv1057617 CNV gain 25217958
nsv1122054 CNV deletion 24896259
nsv1123592 CNV deletion 24896259
nsv471197 CNV loss 18288195
nsv829203 CNV loss 20364138
nsv834191 CNV loss 17160897
nsv9903 CNV loss 18304495
nsv9904 CNV gain+loss 18304495

Variation tolerance for TRIOBP Gene

Residual Variation Intolerance Score: 99.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 23.05; 99.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIOBP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIOBP Gene

Disorders for TRIOBP Gene

MalaCards: The human disease database

(6) MalaCards diseases for TRIOBP Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 28
  • dfnb28
nonsyndromic deafness
  • nonsyndromic hearing loss
non-syndromic genetic deafness
  • isolated genetic deafness
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
autosomal recessive nonsyndromic deafness
  • deafness, autosomal recessive, nonsyndromic )
- elite association - COSMIC cancer census association via MalaCards


  • Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:16385457, ECO:0000269 PubMed:16385458}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TRIOBP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIOBP: view

No data available for Genatlas for TRIOBP Gene

Publications for TRIOBP Gene

  1. Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. (PMID: 16385457) Riazuddin S … Friedman TB (American journal of human genetics 2006) 2 3 4 22 58
  2. Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. (PMID: 16385458) Shahin H … Kanaan M (American journal of human genetics 2006) 2 3 4 58
  3. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. (PMID: 11148140) Seipel K … Streuli M (Journal of cell science 2001) 2 3 4 58
  4. Phosphorylation of Tara by Plk1 is essential for faithful chromosome segregation in mitosis. (PMID: 22820163) Zhu Y … Huang H (Experimental cell research 2012) 3 4 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for TRIOBP Gene

Sources for TRIOBP Gene

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