Aliases for TRIOBP Gene
External Ids for TRIOBP Gene
Previous HGNC Symbols for TRIOBP Gene
Previous GeneCards Identifiers for TRIOBP Gene
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
GeneCards Summary for TRIOBP Gene
TRIOBP (TRIO And F-Actin Binding Protein) is a Protein Coding gene. Diseases associated with TRIOBP include Deafness, Autosomal Recessive 28 and Nonsyndromic Deafness. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and GTP-Rho binding. An important paralog of this gene is MPRIP.
UniProtKB/Swiss-Prot Summary for TRIOBP Gene
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.