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Aliases for TRIML2 Gene

Aliases for TRIML2 Gene

  • Tripartite Motif Family Like 2 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIML2 3 4
  • Tripartite Motif Family-Like Protein 2 3 4
  • SPRY Domain-Containing Protein 6 3 4
  • SPRYD6 3 4
  • Probable E3 Ubiquitin-Protein Ligase TRIML2 3
  • SPRY Domain Containing 6 2
  • EC 4

External Ids for TRIML2 Gene

Previous GeneCards Identifiers for TRIML2 Gene

  • GC04M189250
  • GC04M189012
  • GC04M184748

Summaries for TRIML2 Gene

Entrez Gene Summary for TRIML2 Gene

  • This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for TRIML2 Gene

TRIML2 (Tripartite Motif Family Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is TRIML1.

Additional gene information for TRIML2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIML2 Gene

Genomics for TRIML2 Gene

GeneHancer (GH) Regulatory Elements for TRIML2 Gene

Promoters and enhancers for TRIML2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I188106 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 588.4 +0.2 223 6.1 STAT1 JUN MAX CEBPB EP300 GTF3C2 SP1 JUND GATA3 POLR3A TRIML2 ZFP42 LINC02434 FAUP3
GH04I188105 Promoter 0.5 EPDnew 556.8 +4.1 4090 0.1 TRIML2 FAUP3 ZFP42
GH04I188107 Promoter 0.5 EPDnew 550.8 +4.3 4312 0.1 FAUP3 TRIML2 ZFP42
GH04I188127 Enhancer 0.9 FANTOM5 ENCODE 12.3 -18.2 -18212 1.6 JUN MAX USF2 EP300 SP1 FOSL1 JUND MAFF FOS FOSL2 TRIML2 LINC02434 RNU6-173P TRIML1
GH04I188121 Enhancer 0.4 ENCODE 10.5 -12.2 -12233 0.6 MAX POU5F1 GC04M188122 RNU6-173P TRIML2 TRIML1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIML2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIML2 gene promoter:

Genomic Locations for TRIML2 Gene

Genomic Locations for TRIML2 Gene
18,349 bases
Minus strand

Genomic View for TRIML2 Gene

Genes around TRIML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIML2 Gene

Proteins for TRIML2 Gene

  • Protein details for TRIML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIML2
    Protein Accession:
    Secondary Accessions:
    • B7Z6J6

    Protein attributes for TRIML2 Gene

    387 amino acids
    Molecular mass:
    43983 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIML2 Gene


neXtProt entry for TRIML2 Gene

Post-translational modifications for TRIML2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRIML2 Gene

Domains & Families for TRIML2 Gene

Gene Families for TRIML2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIML2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIML2: view

No data available for UniProtKB/Swiss-Prot for TRIML2 Gene

Function for TRIML2 Gene

Molecular function for TRIML2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for TRIML2 Gene

Phenotypes From GWAS Catalog for TRIML2 Gene

Gene Ontology (GO) - Molecular Function for TRIML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26496610
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRIML2: view
genes like me logo Genes that share phenotypes with TRIML2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIML2 Gene

Localization for TRIML2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIML2 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIML2 Gene

Pathways & Interactions for TRIML2 Gene

SuperPathways for TRIML2 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N7C3-TRIMM_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010033 response to organic substance IEA --
GO:0016567 protein ubiquitination IEA --
GO:0032526 response to retinoic acid IEA --
genes like me logo Genes that share ontologies with TRIML2: view

No data available for Pathways by source and SIGNOR curated interactions for TRIML2 Gene

Drugs & Compounds for TRIML2 Gene

No Compound Related Data Available

Transcripts for TRIML2 Gene

mRNA/cDNA for TRIML2 Gene

Unigene Clusters for TRIML2 Gene

Tripartite motif family-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIML2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP3: -

Relevant External Links for TRIML2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIML2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIML2 Gene

This gene is overexpressed in Testis (x26.7), Brain - Nucleus accumbens (basal ganglia) (x4.3), and Brain - Putamen (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for TRIML2 Gene

This gene is overexpressed in Heart (35.2) and Platelet (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIML2 Gene

Protein tissue co-expression partners for TRIML2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIML2 Gene:


SOURCE GeneReport for Unigene cluster for TRIML2 Gene:


Evidence on tissue expression from TISSUES for TRIML2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TRIML2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIML2 Gene

Orthologs for TRIML2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIML2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIML2 33 34
  • 98.7 (n)
(Bos Taurus)
Mammalia TRIML2 33 34
  • 75.61 (n)
(Canis familiaris)
Mammalia TRIML2 33
  • 74.87 (n)
-- 34
  • 54 (a)
-- 34
  • 48 (a)
(Mus musculus)
Mammalia Triml2 33 16 34
  • 72.42 (n)
(Rattus norvegicus)
Mammalia Triml2 33
  • 71.24 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 39 (a)
-- 34
  • 35 (a)
-- 34
  • 29 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
-- 34
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
Species where no ortholog for TRIML2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIML2 Gene

Gene Tree for TRIML2 (if available)
Gene Tree for TRIML2 (if available)

Paralogs for TRIML2 Gene

(5) SIMAP similar genes for TRIML2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIML2: view

Variants for TRIML2 Gene

Sequence variations from dbSNP and Humsavar for TRIML2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000222836 -- 188,105,260(-) G/A coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000283970 -- 188,095,241(-) AAAAA/AAAA intron_variant
rs1000369986 -- 188,100,471(-) C/A intron_variant
rs10004012 -- 188,097,459(-) A/G intron_variant
rs10004783 -- 188,096,309(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIML2 Gene

Variant ID Type Subtype PubMed ID
dgv332n21 CNV loss 19592680
dgv5496n100 CNV gain 25217958
dgv5499n100 CNV gain 25217958
dgv5501n100 CNV gain 25217958
dgv9439n54 CNV gain 21841781
dgv9440n54 CNV gain 21841781
dgv9441n54 CNV loss 21841781
dgv9442n54 CNV gain 21841781
esv2673712 CNV deletion 23128226
esv2752041 CNV gain 17911159
esv2763831 CNV gain+loss 21179565
esv32613 CNV gain 17666407
esv3569878 CNV loss 25503493
esv3569882 CNV loss 25503493
esv3603611 CNV loss 21293372
nsv1017684 CNV loss 25217958
nsv1019623 CNV gain 25217958
nsv1022128 CNV loss 25217958
nsv1022361 CNV gain 25217958
nsv1022807 CNV gain 25217958
nsv1031097 CNV loss 25217958
nsv1031236 CNV gain 25217958
nsv1031595 CNV gain 25217958
nsv10629 CNV loss 18304495
nsv1067931 OTHER inversion 25765185
nsv461870 CNV gain 19166990
nsv461871 CNV gain 19166990
nsv470098 CNV gain 18288195
nsv519300 CNV gain+loss 19592680
nsv523635 CNV gain 19592680
nsv596456 CNV gain 21841781
nsv596460 CNV loss 21841781
nsv830173 CNV gain 17160897

Variation tolerance for TRIML2 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIML2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIML2 Gene

Disorders for TRIML2 Gene

Additional Disease Information for TRIML2

No disorders were found for TRIML2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIML2 Gene

Publications for TRIML2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  3. Association of tripartite motif family-like 2 (TRIML2) polymorphisms with late-onset Alzheimer's disease risk in a Korean population. (PMID: 27471163) Kang WS … Kim JW (Neuroscience letters 2016) 3 58
  4. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. (PMID: 25256710) Kung CP … Murphy ME (Molecular cancer research : MCR 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for TRIML2 Gene

Sources for TRIML2 Gene

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