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Aliases for TRIM73 Gene

Aliases for TRIM73 Gene

  • Tripartite Motif Containing 73 2 3 5
  • Tripartite Motif-Containing Protein 50B 3 4
  • TRIM50B 3 4
  • Tripartite Motif-Containing Protein 73 3
  • Tripartite Motif-Containing 50B 2
  • Tripartite Motif-Containing 73 2

External Ids for TRIM73 Gene

Previous HGNC Symbols for TRIM73 Gene

  • TRIM50B

Previous GeneCards Identifiers for TRIM73 Gene

  • GC07P074862
  • GC07P075024
  • GC07P074357

Summaries for TRIM73 Gene

GeneCards Summary for TRIM73 Gene

TRIM73 (Tripartite Motif Containing 73) is a Protein Coding gene. An important paralog of this gene is TRIM74.

Additional gene information for TRIM73 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM73 Gene

Genomics for TRIM73 Gene

GeneHancer (GH) Regulatory Elements for TRIM73 Gene

Promoters and enhancers for TRIM73 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I075394 Promoter/Enhancer 0.7 EPDnew Ensembl 550.8 +0.6 572 1.3 LOC541473 TRIM73 NSUN5P1 STAG3L1
GH07I074635 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -759.0 -759027 2 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A ZNF48 ETS1 FOS ZNF202 REST PMS2P3 STAG3L1 NSUN5P1 MIR590 SPDYE5 METTL27 GTF2IRD2 GTF2IRD2B LOC101926943 BUD23
GH07I075637 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 +244.3 244316 3.6 ARNT SIN3A ZNF2 ZBTB7B ZNF766 REST SMARCA4 GLIS1 NBN KDM1A SPDYE5 HIP1 STAG3L1 PMS2P3 NSUN5P1 GTF2IRD2B GTF2IRD2 LOC101926943 TRIM73 DTX2
GH07I075534 Enhancer 1 Ensembl ENCODE 15 +140.2 140178 1.4 HDAC1 PKNOX1 ATF1 FOXA2 BMI1 BATF IRF4 ATF7 ETV6 FOS TRIM73 PMS2P3 GC07M075581 HIP1
GH07I075776 Enhancer 0.9 Ensembl ENCODE 11.9 +381.6 381553 0.5 CTCF BCOR ZNF140 MAX ZMYM3 EBF1 RAD21 ZNF366 POLR2A NFATC1 PMS2P3 NSUN5P1 LOC100133091 STAG3L1 SPDYE5 TRIM73 GTF2IRD2 GTF2IRD2B CCL26 HIP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM73 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM73 gene promoter:

Genomic Locations for TRIM73 Gene

Genomic Locations for TRIM73 Gene
chr7:75,395,063-75,410,996
(GRCh38/hg38)
Size:
15,934 bases
Orientation:
Plus strand
chr7:75,024,337-75,040,279
(GRCh37/hg19)

Genomic View for TRIM73 Gene

Genes around TRIM73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM73 Gene

Proteins for TRIM73 Gene

  • Protein details for TRIM73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UV7-TRI73_HUMAN
    Recommended name:
    Tripartite motif-containing protein 73
    Protein Accession:
    Q86UV7
    Secondary Accessions:
    • Q8N0S3

    Protein attributes for TRIM73 Gene

    Size:
    250 amino acids
    Molecular mass:
    28517 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM73 Gene

Post-translational modifications for TRIM73 Gene

No Post-translational modifications

Other Protein References for TRIM73 Gene

No data available for DME Specific Peptides for TRIM73 Gene

Domains & Families for TRIM73 Gene

Gene Families for TRIM73 Gene

Suggested Antigen Peptide Sequences for TRIM73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UV7

UniProtKB/Swiss-Prot:

TRI73_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM73: view

Function for TRIM73 Gene

Phenotypes From GWAS Catalog for TRIM73 Gene

Gene Ontology (GO) - Molecular Function for TRIM73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM73: view

Phenotypes for TRIM73 Gene

genes like me logo Genes that share phenotypes with TRIM73: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM73 Gene

Localization for TRIM73 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM73 gene
Compartment Confidence
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TRIM73: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM73 Gene

Pathways & Interactions for TRIM73 Gene

SuperPathways for TRIM73 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM73 Gene

Drugs & Compounds for TRIM73 Gene

No Compound Related Data Available

Transcripts for TRIM73 Gene

mRNA/cDNA for TRIM73 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM73 Gene

Tripartite motif containing 73:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM73 Gene

No ASD Table

Relevant External Links for TRIM73 Gene

GeneLoc Exon Structure for
TRIM73
ECgene alternative splicing isoforms for
TRIM73

Expression for TRIM73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM73 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM73 Gene:

TRIM73

SOURCE GeneReport for Unigene cluster for TRIM73 Gene:

Hs.632307
genes like me logo Genes that share expression patterns with TRIM73: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM73 Gene

Orthologs for TRIM73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM73 33
  • 96.53 (n)
TRIM50 34
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TRIM50 34
  • 43 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 43 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim50 34
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 9 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 9 (a)
ManyToMany
Species where no ortholog for TRIM73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM73 Gene

ENSEMBL:
Gene Tree for TRIM73 (if available)
TreeFam:
Gene Tree for TRIM73 (if available)

Paralogs for TRIM73 Gene

(15) SIMAP similar genes for TRIM73 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM73: view

Variants for TRIM73 Gene

Sequence variations from dbSNP and Humsavar for TRIM73 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs111656303 -- 75,402,415(+) G/T intron_variant
rs111923502 -- 75,401,667(+) T/C intron_variant
rs112340704 -- 75,399,739(+) T/C intron_variant
rs112493146 -- 75,398,245(+) T/C intron_variant
rs112728736 -- 75,396,500(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM73 Gene

Variant ID Type Subtype PubMed ID
nsv981535 CNV duplication 23825009
nsv970875 CNV duplication 23825009
nsv831035 CNV loss 17160897
nsv831025 CNV loss 17160897
nsv607478 CNV loss 21841781
nsv528969 CNV gain 19592680
nsv520573 CNV gain+loss 19592680
nsv469664 CNV loss 16826518
nsv428171 CNV gain 18775914
nsv1161563 CNV deletion 26073780
nsv1030447 CNV loss 25217958
nsv1029162 CNV loss 25217958
nsv1023115 CNV gain 25217958
nsv1018460 CNV gain+loss 25217958
nsv1018175 CNV gain 25217958
esv3613678 CNV loss 21293372
esv3571921 CNV loss 25503493
esv34349 CNV gain 17911159
esv2764061 CNV gain+loss 21179565
esv2759537 CNV gain+loss 17122850
dgv6464n100 CNV gain 25217958

Variation tolerance for TRIM73 Gene

Gene Damage Index Score: 1.51; 29.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM73 Gene

Disorders for TRIM73 Gene

Additional Disease Information for TRIM73

No disorders were found for TRIM73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM73 Gene

Publications for TRIM73 Gene

  1. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. (PMID: 18398435) Micale L … Reymond A (European journal of human genetics : EJHG 2008) 3 4 58
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M … Lindquist S (Cell 2012) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for TRIM73 Gene

Sources for TRIM73 Gene

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