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The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015] See more...
Aliases for TRIM71 Gene
Aliases for TRIM71 Gene
External Ids for TRIM71 Gene
- HGNC: 32669
- Entrez Gene: 131405
- Ensembl: ENSG00000206557
- OMIM: 618570
- UniProtKB: Q2Q1W2
Previous GeneCards Identifiers for TRIM71 Gene
- GC03P032836
- GC03P032795
Summaries for TRIM71 Gene
-
The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]
GeneCards Summary for TRIM71 Gene
TRIM71 (Tripartite Motif Containing 71) is a Protein Coding gene. Diseases associated with TRIM71 include Hydrocephalus, Congenital Communicating, 1 and Congenital Communicating Hydrocephalus. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and miRNA binding. An important paralog of this gene is TRIM3.
UniProtKB/Swiss-Prot Summary for TRIM71 Gene
-
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233).
Additional gene information for TRIM71 Gene
- HGNC(32669)
- Entrez Gene(131405)
- Ensembl(ENSG00000206557)
- OMIM(618570)
- UniProtKB(Q2Q1W2)
- Open Targets Platform(ENSG00000206557)
- Search for TRIM71 at DataMed
- Search for TRIM71 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TRIM71 Gene
Genomics for TRIM71 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TRIM71 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TRIM71 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TRIM71
- Top Transcription factor binding sites by QIAGEN in the TRIM71 gene promoter:
-
- AP-4
- E47
- HNF-4alpha1
- HSF2
- ITF-2
- PPAR-alpha
- Tal-1
- Tal-1beta
Genomic Locations for TRIM71 Gene
Genomic Locations for TRIM71 Gene
- chr3:32,817,997-32,897,824
- (GRCh38/hg38)
- Size:
- 79,828 bases
- Orientation:
- Plus strand
- chr3:32,859,510-32,939,318
- (GRCh37/hg19)
- Size:
- 79,809 bases
- Orientation:
- Plus strand
Genomic View for TRIM71 Gene
Genes around TRIM71 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p22.3 by HGNC
- 3p22.3 by Entrez Gene
- 3p22.3 by Ensembl
TRIM71 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TRIM71 Gene
Proteins for TRIM71 Gene
-
Protein details for TRIM71 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q2Q1W2-LIN41_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase TRIM71
- Protein Accession:
- Q2Q1W2
Protein attributes for TRIM71 Gene
- Size:
- 868 amino acids
- Molecular mass:
- 93385 Da
- Quaternary structure:
-
- Interacts (via NHL repeats) with AGO2; the interaction increases in presence of RNA (PubMed:23125361). Interacts with HSP90AA1. Interacts (via NHL repeats) with MOV10, PABPC1, PUM1, PUM2, STAU2, XRN1 and XRN2 in an RNA-dependent manner (PubMed:23125361). Interacts with SHCBP1; leading to enhance its stability (By similarity).
Protein Expression for TRIM71 Gene
Post-translational modifications for TRIM71 Gene
- Autoubiquitinated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TRIM71 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-TRIM71 (internal region) polyclonal antibody
- Novus Biologicals Antibodies for TRIM71
-
Abcam antibodies for TRIM71
- Invitrogen Antibodies for TRIM71 (AFLGC-TRIM71)
-
Biorbyt antibodies for TRIM71
-
Boster Bio Antibodies for TRIM71
-
Custom Antibody ServicesProSci Antibodies for TRIM71
-
Santa Cruz Biotechnology (SCBT) Antibodies for TRIM71
Protein Products
-
OriGene Purified Proteins for TRIM71
- Search Origene for MassSpec and Protein Over-expression Lysates for TRIM71
- Origene Custom Protein Services for TRIM71
- Novus Biologicals proteins for TRIM71
-
Abcam proteins for TRIM71
No data available for DME Specific Peptides for TRIM71 Gene
Domains & Families for TRIM71 Gene
Gene Families for TRIM71 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for TRIM71 Gene
- InterPro:
- Blocks:
-
- B-box zinc finger signature
- ProtoNet:
Suggested Antigen Peptide Sequences for TRIM71 Gene
- GenScript: Design optimal peptide antigens:
-
- Protein lin-41 homolog (LIN41_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q2Q1W2UniProtKB/Swiss-Prot:
LIN41_HUMAN :- The NHL domain, containing the 6 NHL repeats, is necessary and sufficient to target RNA but not to repress mRNA. The minimal region needed to execute repression consists of the coiled coil domain and the Filamin repeat. The RING-type domain is dispensable for mRNA repression.
- Belongs to the TRIM/RBCC family.
- Domain:
-
- The NHL domain, containing the 6 NHL repeats, is necessary and sufficient to target RNA but not to repress mRNA. The minimal region needed to execute repression consists of the coiled coil domain and the Filamin repeat. The RING-type domain is dispensable for mRNA repression.
- Family:
-
- Belongs to the TRIM/RBCC family.
Function for TRIM71 Gene
Molecular function for TRIM71 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
- UniProtKB/Swiss-Prot Induction:
- Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this protein. This requires a let-7 complementary site (LCS) in the 3'-UTR of the mRNA encoding this protein (PubMed:17890240, PubMed:24239284). Down-regulated by retinoic acid in Tera-2 cells (PubMed:15722555).
Enzyme Numbers (IUBMB) for TRIM71 Gene
Phenotypes From GWAS Catalog for TRIM71 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IEA | -- |
| GO:0004842 | ubiquitin-protein transferase activity | IEA,ISS | -- |
| GO:0005515 | protein binding | IPI | 23125361 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for TRIM71 Gene
- MGI mutant phenotypes for TRIM71:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TRIM71:
Animal Models for TRIM71 Gene
- MGI Knock Outs for TRIM71:
-
- Trim71 Trim71<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM71 - Select products 50% OFF >
- * TRIM71 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM71
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM71
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM71
miRNA for TRIM71 Gene
- miRTarBase miRNAs that target TRIM71
-
- hsa-let-7c-5p (MIRT002076)
- hsa-let-7a-5p (MIRT002077)
- mmu-let-7a-5p (MIRT004728)
- mmu-let-7e-5p (MIRT004729)
- dre-let-7a (MIRT005286)
- mmu-miR-125a-5p (MIRT005597)
- mmu-miR-125b-5p (MIRT005598)
- mmu-miR-128-3p (MIRT005599)
- hsa-miR-125b-5p (MIRT006740)
- hsa-miR-17-5p (MIRT051040)
- hsa-let-7b-5p (MIRT243471)
- hsa-let-7d-5p (MIRT243472)
- hsa-let-7e-5p (MIRT243473)
- hsa-let-7f-5p (MIRT243474)
- hsa-miR-98-5p (MIRT243475)
- hsa-let-7g-5p (MIRT243476)
- hsa-let-7i-5p (MIRT243477)
- hsa-miR-3607-3p (MIRT243478)
- hsa-miR-4458 (MIRT243479)
- hsa-miR-4500 (MIRT243480)
- hsa-miR-3927-3p (MIRT243482)
- hsa-miR-3935 (MIRT243483)
- hsa-miR-4495 (MIRT243485)
- hsa-miR-5093 (MIRT243488)
- hsa-miR-5680 (MIRT243489)
- hsa-miR-6831-5p (MIRT243490)
- hsa-miR-3117-3p (MIRT255606)
- hsa-miR-3169 (MIRT255607)
- hsa-miR-3908 (MIRT255609)
- hsa-miR-4503 (MIRT255610)
- hsa-miR-4759 (MIRT255611)
- hsa-miR-8083 (MIRT255613)
- hsa-miR-651-3p (MIRT355451)
- hsa-miR-1252-5p (MIRT407940)
- hsa-miR-593-5p (MIRT533460)
- hsa-miR-383-5p (MIRT533461)
- hsa-miR-6839-5p (MIRT533462)
- hsa-miR-378j (MIRT533463)
- hsa-miR-2115-3p (MIRT533464)
- hsa-miR-1243 (MIRT533465)
- hsa-miR-3156-5p (MIRT533466)
- hsa-miR-182-5p (MIRT533467)
- hsa-miR-1271-5p (MIRT533468)
- hsa-miR-96-5p (MIRT533469)
- hsa-miR-183-5p (MIRT533470)
- hsa-miR-5572 (MIRT533471)
- hsa-miR-6855-5p (MIRT533472)
- hsa-miR-3170 (MIRT533473)
- hsa-miR-6819-5p (MIRT533474)
- hsa-miR-6812-5p (MIRT533475)
- hsa-miR-6737-5p (MIRT533476)
- hsa-miR-4325 (MIRT533477)
- hsa-miR-6858-5p (MIRT533478)
- hsa-miR-4689 (MIRT533479)
- hsa-miR-1224-5p (MIRT533480)
- hsa-miR-3915 (MIRT533481)
- hsa-miR-4473 (MIRT533482)
- hsa-miR-4671-3p (MIRT533483)
- hsa-miR-6881-5p (MIRT533484)
- hsa-miR-1256 (MIRT533485)
- hsa-miR-4653-3p (MIRT533486)
- hsa-miR-4784 (MIRT533487)
- hsa-miR-3150b-3p (MIRT533488)
- hsa-miR-3614-5p (MIRT533489)
- hsa-miR-454-3p (MIRT533490)
- hsa-miR-4295 (MIRT533491)
- hsa-miR-3666 (MIRT533492)
- hsa-miR-301b-3p (MIRT533493)
- hsa-miR-301a-3p (MIRT533494)
- hsa-miR-130b-3p (MIRT533495)
- hsa-miR-130a-3p (MIRT533496)
- hsa-miR-4761-3p (MIRT533497)
- hsa-miR-2110 (MIRT533498)
- hsa-miR-6780b-5p (MIRT533499)
- hsa-miR-4725-3p (MIRT533500)
- hsa-miR-4271 (MIRT533501)
- hsa-miR-4468 (MIRT533502)
- hsa-miR-7155-5p (MIRT533503)
- hsa-miR-637 (MIRT533504)
- hsa-miR-8089 (MIRT533505)
- hsa-miR-4700-5p (MIRT533506)
- hsa-miR-4667-5p (MIRT533507)
- hsa-miR-1298-3p (MIRT533508)
- hsa-miR-2278 (MIRT533509)
- hsa-miR-1276 (MIRT533510)
- hsa-miR-3686 (MIRT533511)
- hsa-miR-452-3p (MIRT533512)
- hsa-miR-6792-5p (MIRT533513)
- hsa-miR-202-3p (MIRT565223)
- hsa-miR-203a-3p (MIRT565224)
- hsa-miR-34c-3p (MIRT565225)
- mmu-miR-670-5p (MIRT580250)
- mmu-miR-351-5p (MIRT580251)
- mmu-miR-696 (MIRT604578)
- mmu-miR-466j (MIRT604579)
- mmu-miR-669m-5p (MIRT604580)
- mmu-miR-466h-5p (MIRT604581)
- mmu-miR-466m-5p (MIRT604582)
- mmu-miR-188-3p (MIRT604583)
- mmu-miR-3057-3p (MIRT604584)
- mmu-miR-329-3p (MIRT604585)
- mmu-miR-466q (MIRT604586)
- mmu-miR-362-3p (MIRT604587)
- hsa-miR-6868-3p (MIRT641827)
- hsa-miR-6086 (MIRT641828)
- hsa-miR-377-5p (MIRT641829)
- hsa-miR-655-5p (MIRT641830)
- hsa-miR-3667-3p (MIRT641831)
- hsa-miR-6734-3p (MIRT641832)
- hsa-miR-329-5p (MIRT641833)
- hsa-miR-133b (MIRT652145)
- hsa-miR-133a-3p (MIRT652146)
- hsa-miR-5587-5p (MIRT652147)
- hsa-miR-6780a-3p (MIRT652148)
- hsa-miR-1273f (MIRT652149)
- hsa-miR-4708-5p (MIRT652150)
- hsa-miR-6088 (MIRT652151)
- hsa-miR-4770 (MIRT652152)
- hsa-miR-143-3p (MIRT652153)
- hsa-miR-4679 (MIRT652154)
- hsa-miR-4677-3p (MIRT652155)
- hsa-miR-4311 (MIRT768560)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM71
- Browse OriGene Inhibitory RNA Products For TRIM71
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM71
Clone Products
- Applied Biological Materials (abm): Clones for TRIM71 - Select products 50% OFF >
- * TRIM71 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TRIM71
- Addgene plasmids for TRIM71
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM71
Cell Line Products
-
Horizon Cell Lines for TRIM71
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM71 Gene
Localization for TRIM71 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TRIM71 Gene
- Cytoplasm, P-body.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| cytoskeleton | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Actin filaments (2)
- Focal adhesion sites (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | ISS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for TRIM71 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Mesodermal Commitment Pathway | ||
| 3 | MicroRNAs in cancer | ||
| 4 | Innate Immune System |
.61
|
|
Pathways by source for TRIM71 Gene
2 BioSystems pathways for TRIM71 Gene
4 Reactome pathways for TRIM71 Gene
1 KEGG pathway for TRIM71 Gene
UniProtKB/Swiss-Prot Q2Q1W2-LIN41_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for TRIM71 Gene
GPS-Prot Interaction Network for TRIM71
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA,ISS | -- |
| GO:0000209 | protein polyubiquitination | IBA | 21873635 |
| GO:0001843 | neural tube closure | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | IEA,ISS | -- |
No data available for SIGNOR curated interactions for TRIM71 Gene
Transcripts for TRIM71 Gene
mRNA/cDNA for TRIM71 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000383763 8704 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TRIM71 - Select products 50% OFF >
- * TRIM71 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TRIM71
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM71
-
Santa Cruz Biotechnology (SCBT) CRISPR for TRIM71
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TRIM71
- Browse OriGene Inhibitory RNA Products For TRIM71
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM71
Clone Products
- Applied Biological Materials (abm): Clones for TRIM71 - Select products 50% OFF >
- * TRIM71 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for TRIM71
- Addgene plasmids for TRIM71
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM71
Relevant External Links for TRIM71 Gene
- GeneLoc Exon Structure for
- TRIM71
Expression for TRIM71 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
-
Ovary (Reproductive System)
- Ovarian Somatic Cells Ovigerous Cord
- Inner Cell Mass (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for TRIM71 Gene
This gene is overexpressed in Testis (x18.2).
This gene is overexpressed in Fetal ovary (16.7), Pancreatic juice (15.2), Liver (14.4), and Testis (12.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM71 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TRIM71
SOURCE GeneReport for Unigene cluster for TRIM71 Gene:
Hs.567678mRNA Expression by UniProt/SwissProt for TRIM71 Gene:
Q2Q1W2-LIN41_HUMAN
Tissue specificity:
Specifically expressed in testis.
Evidence on tissue expression from TISSUES for TRIM71 Gene
- Muscle(2.3)
- Kidney(2.2)
- Nervous system(2.1)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for TRIM71
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM71 Gene
Orthologs for TRIM71 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TRIM71 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TRIM71 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TRIM71 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TRIM71 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Trim71 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Trim71 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TRIM71 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TRIM71 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TRIM71 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486898 30 |
|
||
| Str.10679 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | trim71 30 31 |
|
OneToOne | |
| sbcb205 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6954 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | wech 30 31 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005125 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | lin-41 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for TRIM71 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for TRIM71 Gene
- ENSEMBL:
- Gene Tree for TRIM71 (if available)
- TreeFam:
- Gene Tree for TRIM71 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TRIM71: view image
Paralogs for TRIM71 Gene
Paralogs for TRIM71 Gene
- TRIM3 5
- TRIM2 5
- TRIM9 5
- TRIM21 5
- TRIM10 5
- TRIM26 5
- TRIM27 5
- TRIM7 5
- TRIM58 5
- TRIM56 5
- TRIM72 5
- MEFV 5
- TRIM39 5
- TRIM67 5
- TRIM25 5
- TRIM11 5
- TRIM42 5
- TRIM32 5
- TRIM24 5
- TRIM34 5
- TRIM22 5
- TRIM75P 5
- TRIM6 5
- TRIM6-TRIM34 5
- TRIM5 5
- TRIM15 5
- TRIM47 5
- TRIM62 5
- TRIM38 5
- TRIM41 5
- TRIML1 5
- TRIM17 5
- TRIM33 5
- TRIM69 5
- TRIM4 5
- TRIM68 5
- TRIM60 5
- MID1 5
- TRIM28 5
- TRIM50 5
- TRIM64C 5
- TRIM16 5
- MID2 5
- TRIM35 5
- TRIM66 5
- TRIML2 5
- TRIM46 5
- TRIM29 5
- TRIM77 5
- TRIM64B 5
- TRIM64 5
- TRIM31 5
- TRIM39-RPP21 5
- TRIM14 5
- TRIM36 5
- TRIM49B 5
- TRIM51 5
- TRIM43B 5
- TRIM43 5
- RNF39 5
- TRIM65 5
- TRIM49 5
- TRIM49D1 5
- TRIM49D2 5
- TRIM49C 5
- TRIM54 5
- TRIM51GP 5
- TRIM13 5
- TRIM45 5
- TRIM40 5
- TRIM63 5
- TRIM55 5
- TRIM8 5
- TRIM37 5
- PML 5
- TRIM16L 5
- TRIM73 5
- TRIM48 5
- BSPRY 5
- TRIM52 5
- TRIM74 5
- TRIM44 5
- TRIM61 5
- ENSG00000239920 5
(1) SIMAP similar genes for TRIM71 Gene using alignment to 1 proteins:
- LIN41_HUMAN
Variants for TRIM71 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TRIM71 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 684688 | Likely Pathogenic: Congenital hydrocephalus | 32,891,654(+) | G/A | MISSENSE_VARIANT | |
| 684689 | Likely Pathogenic: Congenital hydrocephalus | 32,891,090(+) | G/A | MISSENSE_VARIANT | |
| 691461 | Uncertain Significance: Pyloric stenosis; Esophageal atresia | 32,890,648(+) | G/T | MISSENSE_VARIANT | |
| 694594 | Pathogenic: HYDROCEPHALUS, CONGENITAL COMMUNICATING, 1 | 32,891,027(+) | G/A | MISSENSE_VARIANT | |
| 694595 | Pathogenic: HYDROCEPHALUS, CONGENITAL COMMUNICATING, 1 | 32,891,591(+) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3595784 | CNV | loss | 21293372 |
| esv6047 | CNV | gain | 19470904 |
| nsv1003285 | CNV | gain | 25217958 |
| nsv822051 | CNV | gain | 20364138 |
| nsv998302 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.35;
26.68% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TRIM71 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TRIM71
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM71 Gene
Disorders for TRIM71 Gene
(6) MalaCards diseases for TRIM71 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hydrocephalus, congenital communicating, 1 |
|
|
| congenital communicating hydrocephalus |
|
|
| congenital hydrocephalus |
|
|
| hydrocephalus |
|
|
| autosomal recessive limb-girdle muscular dystrophy type 2h |
|
|
Search TRIM71 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
LIN41_HUMAN- Hydrocephalus, congenital communicating, 1 (HYDCC1) [MIM:618667]: A form of congenital hydrocephalus, a disease characterized by onset in utero of enlarged ventricles due to accumulation of ventricular cerebrospinal fluid. Affected individuals may have neurologic impairment. HYDCC1 inheritance is autosomal dominant. {ECO:0000269 PubMed:29983323}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for TRIM71
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for TRIM71 Gene
Publications for TRIM71 Gene
- A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. (PMID: 28431233) Treiber T … Meister G (Molecular cell 2017) 3 4
- The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes. (PMID: 24239284) Worringer KA … Yamanaka S (Cell stem cell 2014) 3 4
- The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. (PMID: 23125361) Loedige I … Filipowicz W (Nucleic acids research 2013) 3 4
- Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 41
- Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. (PMID: 17890240) Lin YC … Li WH (Molecular biology and evolution 2007) 3 4
ExternalLinks
Products for TRIM71 Gene
- Custom Antibody Services
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- VectorBuilder Virus packaging for TRIM71 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TRIM71
- Addgene plasmids for TRIM71
- antibodies-online: Show 11 available TRIM71 Antibodies ranked by validation data
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- antibodies-online: Search results for available TRIM71 related products ranked by validation data
- antibodies-online: Show 2 available TRIM71 Proteins ranked by validation data
- Compare Top TRIM71 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TRIM71
- Search Santa Cruz Biotechnology (SCBT) for TRIM71 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TRIM71
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- Horizon Cell Lines for TRIM71
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TRIM71
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TRIM71
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TRIM71
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRIM71
- Boster Bio Antibodies for TRIM71
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for TRIM71
Sources for TRIM71 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (22) IntAct
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- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
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- (87) ApexBio
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- (89) antibodies-online
- (90) CYP
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- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
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- (128) SNPedia
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- (131) ProteoGenix
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- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB