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Aliases for TRIM69 Gene

Aliases for TRIM69 Gene

  • Tripartite Motif Containing 69 2 3 5
  • RFP-Like Domain-Containing Protein Trimless 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM69 3 4
  • Ring Finger Protein 36 2 3
  • RNF36 3 4
  • Tripartite Motif-Containing Protein 69 4
  • E3 Ubiquitin-Protein Ligase TRIM69 3
  • Tripartite Motif-Containing 69 2
  • RING Finger Protein 36 4
  • EC 4
  • HSD-34 3
  • HSD34 3
  • TRIF 3

External Ids for TRIM69 Gene

Previous HGNC Symbols for TRIM69 Gene

  • RNF36

Previous GeneCards Identifiers for TRIM69 Gene

  • GC15P042815
  • GC15P045028
  • GC15P021852
  • GC15P045025
  • GC15P045027
  • GC15P045031
  • GC15P045034

Summaries for TRIM69 Gene

Entrez Gene Summary for TRIM69 Gene

  • This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM69 Gene

TRIM69 (Tripartite Motif Containing 69) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM62.

UniProtKB/Swiss-Prot for TRIM69 Gene

  • May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.

Additional gene information for TRIM69 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM69 Gene

Genomics for TRIM69 Gene

GeneHancer (GH) Regulatory Elements for TRIM69 Gene

Promoters and enhancers for TRIM69 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I044723 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 587.2 -1.1 -1066 9.7 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D GLIS1 RCOR2 TRIM69 LOC100419583 B2M PATL2 SPG11 GC15P044732 GC15M044672
GH15I044733 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 575.2 +6.9 6872 4.1 HDGF ATF1 ARNT YBX1 NCOA2 ATF7 RUNX3 JUNB NCOA1 ZNF592 TRIM69 SQOR GC15P044732 ENSG00000276121
GH15I044705 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.2 -17.5 -17520 11.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 IRF4 B2M PATL2 SPG11 CTDSPL2 TRIM69 ENSG00000259563 SPATA5L1 WDR76 CASC4 GC15M044672
GH15I044783 Enhancer 1.6 FANTOM5 Ensembl ENCODE 21.5 +55.6 55624 1.7 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF207 GC15M044783 TRIM69 B2M GC15M044790
GH15I044717 Enhancer 1.2 Ensembl ENCODE dbSUPER 23.8 -8.9 -8857 4.7 PKNOX1 FOXA2 SMAD1 BMI1 BATF KLF5 IRF4 POLR2B E2F8 ETV6 TRIM69 GC15M044672 B2M LOC100419583
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM69 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM69 gene promoter:

Genomic Locations for TRIM69 Gene

Genomic Locations for TRIM69 Gene
38,842 bases
Plus strand

Genomic View for TRIM69 Gene

Genes around TRIM69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM69 Gene

Proteins for TRIM69 Gene

  • Protein details for TRIM69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM69
    Protein Accession:
    Secondary Accessions:
    • A8MX03
    • Q309B0
    • Q4G1A5
    • Q6W897
    • Q8IYY3
    • Q8WY16
    • Q8WY17

    Protein attributes for TRIM69 Gene

    500 amino acids
    Molecular mass:
    57419 Da
    Quaternary structure:
    • Interacts with PML.

    Three dimensional structures from OCA and Proteopedia for TRIM69 Gene

    Alternative splice isoforms for TRIM69 Gene


neXtProt entry for TRIM69 Gene

Post-translational modifications for TRIM69 Gene

  • Phosphorylated. Phosphorylation is necessary for nuclear localization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM69 Gene

Domains & Families for TRIM69 Gene

Gene Families for TRIM69 Gene

Suggested Antigen Peptide Sequences for TRIM69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity and for nuclear localization and aggregation.
  • Belongs to the TRIM/RBCC family.
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity and for nuclear localization and aggregation.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM69: view

Function for TRIM69 Gene

Molecular function for TRIM69 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.

Enzyme Numbers (IUBMB) for TRIM69 Gene

Phenotypes From GWAS Catalog for TRIM69 Gene

Gene Ontology (GO) - Molecular Function for TRIM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM69: view
genes like me logo Genes that share phenotypes with TRIM69: view

Animal Model Products

CRISPR Products

miRNA for TRIM69 Gene

miRTarBase miRNAs that target TRIM69

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM69 Gene

Localization for TRIM69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM69 Gene

Cytoplasm. Nucleus. Nucleus speckle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM69 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TRIM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23131556
GO:0005737 cytoplasm IDA,IEA 23131556
GO:0005829 cytosol TAS --
GO:0016607 nuclear speck IDA,IEA 23131556
genes like me logo Genes that share ontologies with TRIM69: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRIM69 Gene

Pathways & Interactions for TRIM69 Gene

genes like me logo Genes that share pathways with TRIM69: view

Pathways by source for TRIM69 Gene

UniProtKB/Swiss-Prot Q86WT6-TRI69_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM69: view

No data available for SIGNOR curated interactions for TRIM69 Gene

Drugs & Compounds for TRIM69 Gene

No Compound Related Data Available

Transcripts for TRIM69 Gene

Unigene Clusters for TRIM69 Gene

Tripartite motif containing 69:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM69 Gene

No ASD Table

Relevant External Links for TRIM69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM69 Gene

Protein differential expression in normal tissues from HIPED for TRIM69 Gene

This gene is overexpressed in Heart (39.5) and Urinary Bladder (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM69 Gene

Protein tissue co-expression partners for TRIM69 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM69 Gene:


SOURCE GeneReport for Unigene cluster for TRIM69 Gene:


Evidence on tissue expression from TISSUES for TRIM69 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with TRIM69: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM69 Gene

Orthologs for TRIM69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM69 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM69 33 34
  • 99.33 (n)
(Canis familiaris)
Mammalia TRIM69 33 34
  • 90 (n)
(Bos Taurus)
Mammalia TRIM69 33 34
  • 88.6 (n)
(Mus musculus)
Mammalia Trim69 33 16 34
  • 84.44 (n)
(Rattus norvegicus)
Mammalia Trim69 33
  • 83.77 (n)
(Monodelphis domestica)
Mammalia TRIM69 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM69 34
  • 54 (a)
(Gallus gallus)
Aves -- 34
  • 23 (a)
(Anolis carolinensis)
Reptilia TRIM69 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731436 33
  • 57.52 (n)
(Danio rerio)
Actinopterygii CU929328.1 34
  • 28 (a)
Species where no ortholog for TRIM69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM69 Gene

Gene Tree for TRIM69 (if available)
Gene Tree for TRIM69 (if available)

Paralogs for TRIM69 Gene

genes like me logo Genes that share paralogs with TRIM69: view

Variants for TRIM69 Gene

Sequence variations from dbSNP and Humsavar for TRIM69 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000075100 -- 44,740,343(+) C/A/T intron_variant
rs1000108374 -- 44,747,340(+) A/G intron_variant
rs1000113109 -- 44,753,447(+) T/C intron_variant
rs1000140840 -- 44,759,868(+) C/G coding_sequence_variant, missense_variant
rs1000154457 -- 44,764,087(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM69 Gene

Variant ID Type Subtype PubMed ID
esv2760029 CNV gain+loss 17122850
nsv1116069 CNV deletion 24896259
nsv819242 CNV loss 19587683
nsv832990 CNV gain 17160897

Variation tolerance for TRIM69 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM69 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM69 Gene

Disorders for TRIM69 Gene

Additional Disease Information for TRIM69

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TRIM69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM69 Gene

Publications for TRIM69 Gene

  1. Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation. (PMID: 23131556) Han Y … Wang L (Biochemical and biophysical research communications 2012) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Forced expression of RNF36 induces cell apoptosis. (PMID: 12837286) Shyu HW … Li H (Experimental cell research 2003) 3 22 58

Products for TRIM69 Gene

Sources for TRIM69 Gene

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